Abstract：
:Vaccines have drastically reduced the mortality and morbidity of many diseases. However, vaccines have historically been developed empirically, and recent development of vaccines against current pandemics such as HIV and malaria has been met with difficulty. The advent of high-throughput technologies, coupled with systems biological methods of data analysis, has enabled researchers to interrogate the entire complement of a variety of molecular components within cells, and characterize the myriad interactions among them in order to model and understand the behavior of the system as a whole. In the context of vaccinology, these tools permit exploration of the molecular mechanisms by which vaccines induce protective immune responses. Here we review the recent advances, challenges, and potential of systems biological approaches in vaccinology. If the challenges facing this developing field can be overcome, systems vaccinology promises to empower the identification of early predictive signatures of vaccine response, as well as novel and robust correlates of protection from infection. Such discoveries, along with the improved understanding of immune responses to vaccination they impart, will play an instrumental role in development of the next generation of rationally designed vaccines.
journal_name
Vaccinejournal_title
Vaccineauthors
Hagan T,Nakaya HI,Subramaniam S,Pulendran Bdoi
10.1016/j.vaccine.2015.03.072subject
Has Abstractpub_date
2015-09-29 00:00:00pages
5294-301issue
40eissn
0264-410Xissn
1873-2518pii
S0264-410X(15)00391-6journal_volume
33pub_type
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