Chemistry of a new investigational quadrivalent meningococcal conjugate vaccine that is immunogenic at all ages.

abstract：:Vaccine hesitancy is increasing and failure to vaccinate is well-recognised in Europe as a contributing factor to outbreaks of infectious diseases. In Lothian and Scotland, low vaccine uptake has been seen in migrants - notably in the Polish group who have arrived since 2004. The recent Vaccine Confidence in European ...

journal_title：Vaccine

authors： Gorman DR,Bielecki K,Willocks LJ,Pollock KG

更新日期：2019-05-06 00:00:00

abstract：:Induction of broad HIV-1 neutralizing antibodies should be a major goal of an effective HIV-1 vaccine. However, B cells are severely damaged during HIV-1 infection with loss of memory B cells and decline of serological memory. The molecular events leading to B cell damage must be further characterized with the aim of ...

journal_title：Vaccine

authors： Cagigi A,Nilsson A,De Milito A,Chiodi F

更新日期：2008-06-06 00:00:00

abstract：:Poor routine immunization coverage in India has led to a large burden of vaccine-preventable diseases borne by children under 5 years of age. Despite efforts to strengthen infrastructure and service delivery in the past decade, immunization coverage rates have reached a plateau. To meet the formidable needs of India's...

journal_title：Vaccine

authors： Patel AR,Nowalk MP

更新日期：2010-01-08 00:00:00

abstract：:Enterotoxemia, a disease that affects domestic ruminants, is caused mainly by the epsilon toxin from Clostridium perfringens type D. Its eradication is virtually impossible, control and prophylaxis are based on systematic vaccination of herds with epsilon toxoids that are efficient in inducing protective antibody prod...

journal_title：Vaccine

authors： Lobato FC,Lima CG,Assis RA,Pires PS,Silva RO,Salvarani FM,Carmo AO,Contigli C,Kalapothakis E

更新日期：2010-08-31 00:00:00

abstract：BACKGROUND:The recent Ebola outbreak in West Africa led to the use of a variety of different platform technologies for assaying antibodies because of the difficulties of handling the live virus. The same types of method could be applied rapidly to other infections when they emerge. There is a need to compare quantitati...

journal_title：Vaccine

authors： Wilkinson DE,Page M,Mattiuzzo G,Hassall M,Dougall T,Rigsby P,Stone L,Minor P

更新日期：2017-03-01 00:00:00

abstract：:Biodegradable nanoparticles coated with proteins represent a promising method for in vivo delivery of vaccines. Here we used a rabbit model to compare quantitatively and qualitatively the antibody responses induced by poly(D,L-lactide) nanoparticles (PLA) and by emulsion adjuvant MF59 using three HIV-1 antigens: p24ga...

journal_title：Vaccine

authors： Guillon C,Mayol K,Terrat C,Compagnon C,Primard C,Charles MH,Delair T,Munier S,Verrier B

更新日期：2007-10-23 00:00:00

abstract：BACKGROUND:In 2003, severe acute respiratory syndrome (SARS) resulted in hundreds of infections and deaths globally. We aim to assess immunogenicity and protective efficacy of purified inactivated Vero-cell SARS vaccine in monkeys. METHODS:The cultures of SARS coronavirus (SARS-CoV) BJ-01 strain infected Vero cells we...

journal_title：Vaccine

authors： Qin E,Shi H,Tang L,Wang C,Chang G,Ding Z,Zhao K,Wang J,Chen Z,Yu M,Si B,Liu J,Wu D,Cheng X,Yang B,Peng W,Meng Q,Liu B,Han W,Yin X,Duan H,Zhan D,Tian L,Li S,Wu J,Tan G,Li Y,Li Y,Liu Y,Liu H,Lv F

更新日期：2006-02-13 00:00:00

abstract：:Vaccination is an effective strategy to prevent pneumococcal diseases. Currently, licensed vaccines include the pneumococcal polysaccharide vaccine (PPSV) and the pneumococcal conjugate vaccine (PCV), which target some of the most common of the 94 serotypes of S. pneumoniae based on their capsular composition. However...

journal_title：Vaccine

authors： Nagai K,Domon H,Maekawa T,Hiyoshi T,Tamura H,Yonezawa D,Habuka R,Saitoh A,Terao Y

更新日期：2019-01-03 00:00:00

abstract：:A new rabies vaccine was developed from Vero cells adhered to microcarriers, cultivated in a bioreactor in serum-free medium and infected with the PV/VERO-Paris rabies virus strain. The viral suspensions were concentrated by tangential filtration, purified by chromatography and inactivated with beta-propiolactone. In ...

journal_title：Vaccine

authors： Frazatti-Gallina NM,Mourão-Fuches RM,Paoli RL,Silva ML,Miyaki C,Valentini EJ,Raw I,Higashi HG

更新日期：2004-12-09 00:00:00

abstract：:Carbopol is a polyanionic carbomer gel used in man for a variety of topical applications and drug delivery purposes. Here we show that subcutaneous administration of carbopol with glycoprotein antigens elicits unusually strong specific adaptive immune responses in mice. Recombinant soluble HIV-1 envelope glycoprotein ...

journal_title：Vaccine

authors： Krashias G,Simon AK,Wegmann F,Kok WL,Ho LP,Stevens D,Skehel J,Heeney JL,Moghaddam AE,Sattentau QJ

更新日期：2010-03-16 00:00:00

abstract：:The recent resurgence of pertussis in England and Wales has been marked by infant deaths and rising cases in teens and adults. To understand which age cohorts are most responsible for these trends, we employed three separate statistical methods to analyze high-resolution pertussis reports from 1982 to 2012. The fine-g...

journal_title：Vaccine

authors： Bento AI,Riolo MA,Choi YH,King AA,Rohani P

更新日期：2018-02-21 00:00:00

abstract：:Immune responses to the infectious bronchitis virus (IBV) nucleocapsid protein were studied using a recombinant-DNA expression product. In mice, a lymphocyte proliferative response and a delayed-type hypersensitivity reaction to IBV were induced upon immunization with this nucleocapsid protein. Next, we studied the ro...

journal_title：Vaccine

authors： Boots AM,Benaissa-Trouw BJ,Hesselink W,Rijke E,Schrier C,Hensen EJ

更新日期：1992-01-01 00:00:00

abstract：:A number of clinical reports of drug interactions with influenza vaccine have been made. We hypothesized that CYP3A4 activity would decrease following influenza immunization. Fifteen healthy subjects had erythromycin breath tests (ERMBT) and influenza antibody titer hemagglutinin inhibition assay (HIA) before and afte...

journal_title：Vaccine

authors： Hayney MS,Hammes RJ,Fine JP,Bianco JA

更新日期：2001-12-12 00:00:00

abstract：:A prototype H7 influenza vaccine constructed based on the H7N7 outbreak in 2003 was tested for the protective efficacy against the novel H7N9 virus in a lethal murine challenge model. Serum samples from vaccinated mice showed significant neutralizing activity against the H7N9 virus and the mice were completely protect...

journal_title：Vaccine

authors： Tang LH,Lim JH,Kuah LF,Lau YF

更新日期：2014-09-22 00:00:00

abstract：:Our initial results with a bovine papilloma virus (BPV) vector expression system indicated that we could produce significant amounts of Epstein-Barr virus (EBV) gp340/220 in the supernatant of a mouse fibroblast cell line. We have now extended these findings to show that the truncated version of gp340/220, where the m...

journal_title：Vaccine

authors： Madej M,Conway MJ,Morgan AJ,Sweet J,Wallace L,Qualtiere LF,Arrand JR,Mackett M

更新日期：1992-01-01 00:00:00

abstract：:Pseudorabies Virus (PRV) is the causative agent of Pseudorabies (PR), also known as Aujeszky's Disease, one of the most important infectious diseases in swine, resulting in huge economic losses to the swine industry globally. The emergence of mutant PRV strains after 2011 resulted in a sharp decrease in the efficacy o...

journal_title：Vaccine

authors： Zhang T,Liu Y,Chen Y,Wang A,Feng H,Wei Q,Zhou E,Zhang G

更新日期：2020-09-03 00:00:00

abstract：:Recognition of the acute and chronic burden of respiratory syncytial virus (RSV) lower respiratory tract infections (LRTI) sparked a wave of initiatives to develop preventive and therapeutic products against the pathogen in recent years. RSV is a leading cause of hospitalization in infants in industrialized and develo...

journal_title：Vaccine

authors： Polack FP

更新日期：2015-11-25 00:00:00

abstract：AIMS:The study was designed to evaluate a novel cationic lipid DNA adjuvant (N3) and its function for HIV-1gp160/rev DNA plasmid delivered intranasally. The primary N3/HIV-DNA plasmid immunizations were boosted intranasally with a gp41 peptide in a anionic L3 adjuvant. This novel prime-boost strategy of mucosal immuniz...

journal_title：Vaccine

authors： Hinkula J,Devito C,Zuber B,Benthin R,Ferreira D,Wahren B,Schröder U

更新日期：2006-05-22 00:00:00

abstract：:Lyme borreliosis (LB) is the most common vector-borne disease in the northern hemisphere and there is no vaccine available for disease prevention. The majority of LB cases in Europe are caused by four different Borrelia species expressing six different OspA serotypes, whereas in the US only one of these serotypes is p...

journal_title：Vaccine

authors： Comstedt P,Hanner M,Schüler W,Meinke A,Schlegl R,Lundberg U

更新日期：2015-11-04 00:00:00

abstract：:The glutamate-rich protein (GLURP) of P. falciparum is the target of cytophilic antibodies which are significantly associated with protection against clinical malaria. A phase 1 clinical trial was conducted in healthy adult volunteers with the long synthetic peptide (LSP) GLURP(85-213) combined with either Aluminum Hy...

journal_title：Vaccine

authors： Hermsen CC,Verhage DF,Telgt DS,Teelen K,Bousema JT,Roestenberg M,Bolad A,Berzins K,Corradin G,Leroy O,Theisen M,Sauerwein RW

更新日期：2007-04-12 00:00:00

abstract：:Myxoma virus, a member of the Poxviridae family (genus Leporipoxvirus) is the agent responsible for myxomatosis in the European rabbit. Recombinant myxoma viruses expressing the capsid gene of an F9 strain of feline calicivirus (FCV) were constructed from an apathogenic, laboratory attenuated, isolate of myxoma virus....

journal_title：Vaccine

authors： McCabe VJ,Tarpey I,Spibey N

更新日期：2002-06-07 00:00:00

abstract：:Immunization with a combination of several virulence-associated proteins is one of the strategies of developing effective protein-based vaccines to enhance the protection against Streptococcus pneumoniae. In this study, we evaluated the protection effects against pneumococcal infection caused by S. pneumoniae TIGR4 in...

journal_title：Vaccine

authors： Cao J,Chen D,Xu W,Chen T,Xu S,Luo J,Zhao Q,Liu B,Wang D,Zhang X,Shan Y,Yin Y

更新日期：2007-06-28 00:00:00

abstract：BACKGROUND:While vaccines not covered by China's Expanded Program on Immunization can be received voluntarily with out-of-pocket payment, the uptake of self-paid vaccines in China is low. OBJECTIVE:To investigate willingness to pay (WTP) for self-paid vaccines and its determinants in China. METHODS:We interviewed 216...

journal_title：Vaccine

authors： Hou Z,Jie Chang,Yue D,Fang H,Meng Q,Zhang Y

更新日期：2014-07-31 00:00:00

abstract：BACKGROUND:Vaccination coverage is the usual metrics to evaluate the immunization programs performance. For the 10-valent pneumococcal conjugate (PCV10) vaccine, measuring the delay of vaccination is also important, particularly as younger children are at increased risk of disease. Routinely collected administrative da...

journal_title：Vaccine

authors： Sartori AL,Minamisava R,Afonso ET,Policena GM,Pessoni GC,Bierrenbach AL,Andrade AL

更新日期：2017-02-15 00:00:00

abstract：:Vaccines have drastically reduced the mortality and morbidity of many diseases. However, vaccines have historically been developed empirically, and recent development of vaccines against current pandemics such as HIV and malaria has been met with difficulty. The advent of high-throughput technologies, coupled with sys...

journal_title：Vaccine

authors： Hagan T,Nakaya HI,Subramaniam S,Pulendran B

更新日期：2015-09-29 00:00:00

abstract：:The combined sheep pox and Peste des Petits ruminants (PPR) vaccine was prepared in lyophilized form containing recommended doses of both vaccine viruses. Safety and immunogenicity of this combined vaccine was evaluated in sheep. Sheep immunized subcutaneously with 1ml of live attenuated vaccine consisting of 10(3)TCI...

journal_title：Vaccine

authors： Chaudhary SS,Pandey KD,Singh RP,Verma PC,Gupta PK

更新日期：2009-04-28 00:00:00

abstract：:Though widely used, the BCG vaccine has had little apparent effect on rates of adult pulmonary tuberculosis. Moreover, the risk of disseminated BCG disease in immunocompromised individuals means that improved TB vaccines ideally need to be able to efficiently prime mycobacterially-naïve individuals as well as boost in...

journal_title：Vaccine

authors： van Dissel JT,Arend SM,Prins C,Bang P,Tingskov PN,Lingnau K,Nouta J,Klein MR,Rosenkrands I,Ottenhoff TH,Kromann I,Doherty TM,Andersen P

更新日期：2010-04-30 00:00:00

abstract：:The long-term impact of Haemophilus influenzae type b (Hib) conjugate vaccine, introduced throughout Latin America in the late 1990s, has not been evaluated. Active surveillance for H. influenzae meningitis was performed from August 9, 1996 to August 8, 2004 in Metropolitan Salvador, Brazil. Five years after the intro...

journal_title：Vaccine

authors： Ribeiro GS,Lima JB,Reis JN,Gouveia EL,Cordeiro SM,Lobo TS,Pinheiro RM,Ribeiro CT,Neves AB,Salgado K,Silva HR,Reis MG,Ko AI

更新日期：2007-05-30 00:00:00

abstract：:Recent outbreaks of a novel H7N9 avian influenza virus in humans in China raise pandemic concerns and underscore an urgent need to develop effective vaccines. Theoretically, live influenza vaccines are of multiple advantages over traditional inactivated influenza vaccines to be used in a pandemic, because they can be ...

journal_title：Vaccine

authors： Jiang WM,Wang SC,Liu HL,Yu JM,Du X,Hou GY,Li JP,Liu S,Wang KC,Zhuang QY,Liu XM,Chen JM

更新日期：2014-11-12 00:00:00

abstract：:The tetanus and diphtheria vaccination programme in Finland has been running for 50 years. After primary doses, tetanus boosters have been offered to men in military service and decennial boosters recommended for all through the adult life. For 30 years a diphtheria booster was only offered to men in the military serv...

journal_title：Vaccine

authors： Olander RM,Auranen K,Härkänen T,Leino T

更新日期：2009-08-27 00:00:00