A vero cell derived combined vaccine against sheep pox and Peste des Petits ruminants for sheep.

Abstract:

:The combined sheep pox and Peste des Petits ruminants (PPR) vaccine was prepared in lyophilized form containing recommended doses of both vaccine viruses. Safety and immunogenicity of this combined vaccine was evaluated in sheep. Sheep immunized subcutaneously with 1ml of live attenuated vaccine consisting of 10(3)TCID(50) each of sheep pox virus (SPV) Romanian Fanar (RF) strain and Peste des Petits ruminants virus (PPRV-Sungri/96 strain) were monitored for clinical and serological responses for a period of four weeks post immunization (pi) and two week post challenge (pc). Specific antibodies directed to sheep pox virus could be demonstrated by indirect ELISA and serum neutralization test (SNT). Competitive ELISA and SNT were used for demonstration of antibodies to PPR virus. All the immunized animals resisted challenge with virulent SPV or PPRV on day 30pi, while control animals developed characteristic signs of disease. Specific virus could be detected in the unvaccinated control animals after challenge but not from any of the immunized sheep. Combined vaccine was found to be safe and potent as evident from sero conversion as well as challenge studies in sheep. This indicates that component vaccines did not interfere each other and can be used in target population for economic vaccination strategies.

journal_name

Vaccine

journal_title

Vaccine

authors

Chaudhary SS,Pandey KD,Singh RP,Verma PC,Gupta PK

doi

10.1016/j.vaccine.2009.01.104

subject

Has Abstract

pub_date

2009-04-28 00:00:00

pages

2548-53

issue

19

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(09)00167-4

journal_volume

27

pub_type

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