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B cell immunopathology during HIV-1 infection: lessons to learn for HIV-1 vaccine design.

Abstract：

:Induction of broad HIV-1 neutralizing antibodies should be a major goal of an effective HIV-1 vaccine. However, B cells are severely damaged during HIV-1 infection with loss of memory B cells and decline of serological memory. The molecular events leading to B cell damage must be further characterized with the aim of selecting vaccine components allowing preservation of B cell functions. This review focuses on B cell damage and antibody responses in HIV-1-infected patients during vaccination studies with viral and bacterial antigens. In addition novel data indicate that B cell activation may be at the basis of impaired immune responses.

journal_name

Vaccine

journal_title

Vaccine

authors

Cagigi A,Nilsson A,De Milito A,Chiodi F

doi

10.1016/j.vaccine.2007.11.063

subject

Has Abstract

pub_date

2008-06-06 00:00:00

pages

3016-25

issue

24

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(07)01381-3

journal_volume

26

pub_type

杂志文章,评审

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