Long-term follow-up: no effect of therapeutic vaccination with HIV-1 p17/p24:Ty virus-like particles on HIV-1 disease progression.

abstract：:Continuing investments in vaccine innovation are insufficiently translated into market entries of novel vaccines. This innovation paradox is in part caused by stakeholders lacking complete understanding of the complex array of steps necessary for vaccine development and collaboration difficulties between the wide vari...

journal_title：Vaccine

authors： Van de Burgwal LHM,Ribeiro CDS,Van der Waal MB,Claassen E

更新日期：2018-11-26 00:00:00

abstract：:Chikungunya virus is an emerging pathogen initially found in East Africa and currently spread into the Indian Ocean Islands, many regions of South East Asia, and in the Americas. No licensed vaccines against this eminent pathogen are available and thus intensive research in this field is a priority. This review presen...

journal_title：Vaccine

authors： Salazar-González JA,Angulo C,Rosales-Mendoza S

更新日期：2015-07-17 00:00:00

abstract：:Technology transfer is a promising approach to increase vaccine production at an affordable price in developing countries. In the case of influenza, it is imperative that developing countries acquire the technology to produce pandemic vaccines through the transfer of know-how, as this will be the only way for the majo...

journal_title：Vaccine

authors： Miyaki C,Meros M,Precioso AR,Raw I

更新日期：2011-07-01 00:00:00

abstract：:We tested whether pilus proteins of rabbit diarrhoeagenic Escherichia coli (RDEC-1), incorporated into biodegradable microspheres, could function as safe and effective oral immunogens in the rabbit diarrhoea model. The RDEC-1 adhesin, AF/R1, incorporated into poly(D,L-lactide-co-glycolide) microspheres, was administer...

journal_title：Vaccine

authors： McQueen CE,Boedeker EC,Reid R,Jarboe D,Wolf M,Le M,Brown WR

更新日期：1993-01-01 00:00:00

abstract：:Transmission-blocking vaccines against malaria parasites target molecules expressed by sexual stage parasites to elicit antibodies that prevent the infection of the mosquito vector. Pvs25 and Pvs28, expressed on the surface of ookinetes, are potential candidates for such a vaccine and induce antibodies that block the ...

journal_title：Vaccine

authors： Hisaeda H,Collins WE,Saul A,Stowers AW

更新日期：2001-12-12 00:00:00

abstract：BACKGROUND AND AIMS:Trans-placentally acquired antibodies can protect infants from infection in the first months of life. However, high concentrations of antibody at birth may impact the infant's own immune response to primary immunization. We examine the relationship between concentration of specific antibody to Borde...

journal_title：Vaccine

authors： Jones C,Pollock L,Barnett SM,Battersby A,Kampmann B

更新日期：2014-02-12 00:00:00

abstract：:Epitopes in HIV polymerase were analyzed by peptide binding to human leukocyte antigen (HLA) A0201 molecules, the most frequent HLA class in the Caucasian population. We found that HIV-1 protease peptides representing both the wild type and anticipated drug resistance variants of the sequence bound well to HLA-A0201. ...

journal_title：Vaccine

authors： Boberg A,Sjöstrand D,Rollman E,Hinkula J,Zuber B,Wahren B

更新日期：2006-05-22 00:00:00

abstract：:A human influenza B/Lee/40 virus was cold-adapted by serial passages in embryonated chicken eggs, at progressively lower temperatures, for possible use as a future influenza B vaccine donor strain. Temperature sensitive and cold-adapted phenotypes were achieved as a consequence of the adaptation process. It was determ...

journal_title：Vaccine

authors： Seo SU,Byun YH,Lee EY,Jung EJ,Jang YH,Kim HA,Ha SH,Lee KH,Seong BL

更新日期：2008-02-13 00:00:00

abstract：:Targeting dendritic cell mannose receptors by mannosylating antigens represents a promising vaccination strategy. Using the model antigen ovalbumin (OVA) expressed recombinantly in bacterial and yeast vectors, we have previously demonstrated fungal mannosylation enhances antigen immunogenicity in the context of CD4(+)...

journal_title：Vaccine

authors： Luong M,Lam JS,Chen J,Levitz SM

更新日期：2007-05-30 00:00:00

abstract：:Historical evidence demonstrates the validity of the concept "Grand Convergence". The Lancet commission identified the major challenges facing low and lower middle income countries including the unfinished agenda, non-communicable diseases and injuries and an approach to funding and achieving these objectives along wi...

journal_title：Vaccine

authors： Mahmoud A

更新日期：2017-01-20 00:00:00

abstract：:Cervical cancer that is associated with high-risk human papillomaviruses (HPV) is the most common malignancy in Indian women. Therefore, the establishment of a prevention program is urgently required considering both vaccination and screening. However, relatively little is known about the prevalence of the different H...

journal_title：Vaccine

authors： Gheit T,Vaccarella S,Schmitt M,Pawlita M,Franceschi S,Sankaranarayanan R,Sylla BS,Tommasino M,Gangane N

更新日期：2009-01-29 00:00:00

abstract：:Pertussis incidence in Piemonte (Italy) is now at the lowest level ever reached (0.85 per 100,000 in 2010) but the disease is still endemic in infants (54 per 100,000 in 2005-2010). Parental "cocoon" immunization has been proposed in some countries (i.e. United States, France) as a measure to protect newborns from ser...

journal_title：Vaccine

authors： Meregaglia M,Ferrara L,Melegaro A,Demicheli V

更新日期：2013-02-06 00:00:00

abstract：:To evaluate the usefulness of a DNA vaccine for chickens, we constructed a plasmid vector expressing the Newcastle disease virus F protein (NDV-F) under the control of the human cytomegalovirus immediate early enhancer and chicken beta-actin gene promoter. One-week-old chickens injected intramusculary with the circula...

journal_title：Vaccine

authors： Sakaguchi M,Nakamura H,Sonoda K,Hamada F,Hirai K

更新日期：1996-06-01 00:00:00

abstract：:Among strategies aimed at developing new nanoparticle-based vaccines, exosomes hold much promise. They are nanovesicles released by basically all eukaryotic cell types originating from intraluminal vesicles which accumulate in multivesicular bodies. Exosomes have immunogenic properties whose strength correlates with t...

journal_title：Vaccine

authors： Lattanzi L,Federico M

更新日期：2012-11-26 00:00:00

abstract：:Current infant vaccination against pertussis in North America and Australia requires three doses of vaccines including diphtheria, tetanus and acellular pertussis antigens (DTaP) at 2, 4 and 6 months of age. Interest is growing in the possibility that vaccination at birth might provide earlier protection of infants, b...

journal_title：Vaccine

authors： White OJ,Rowe J,Richmond P,Marshall H,McIntyre P,Wood N,Holt PG

更新日期：2010-03-19 00:00:00

abstract：:A newly developed human diploid cell rabies vaccine (Lyssavac-HDC), produced without added serum albumin and with an effort to remove the virus-inactivating beta-propriolactone prior to addition of the gelatin, L-cysteine and potassium phosphate stabilizer, was tested for safety immunogenicity, adverse reactions and e...

journal_title：Vaccine

authors： Wilde H,Glueck R,Khawplod P,Cryz SJ,Tantawichien T,Thipkong P,Chomchey P,Prakongsri S,Benjavongkulchai M,Sumboonanondha A

更新日期：1995-04-01 00:00:00

abstract：BACKGROUND:Nasal vaccination is considered to be a promising alternative for parenteral vaccination against influenza virus as it is non-invasive and offers the opportunity to elicit strong antigen-specific responses both systemic and locally at the port of entry of the pathogen. Previous studies showed that non-living...

journal_title：Vaccine

authors： Keijzer C,Haijema BJ,Meijerhof T,Voorn P,de Haan A,Leenhouts K,van Roosmalen ML,van Eden W,Broere F

更新日期：2014-05-19 00:00:00

abstract：:Lassa virus (LASV) causes a severe hemorrhagic fever endemic throughout western Africa. Because of the ability to cause lethal disease in humans, limited treatment options, and potential as a bioweapon, the need for vaccines to prevent LASV epidemic is urgent. However, LASV vaccine development has been hindered by the...

journal_title：Vaccine

authors： Li Q,Liu Q,Huang W,Wu J,Nie J,Wang M,Zhao C,Zhang L,Wang Y

更新日期：2017-09-12 00:00:00

abstract：BACKGROUND:Persons with primary immunodeficiency disorders (PIDD) who receive oral poliovirus vaccine (OPV) or are household contacts of OPV recipients are at risk of excreting immunodeficiency-associated vaccine-derived polioviruses (iVDPVs). iVDPVs can be transmitted and cause paralytic polio. The objective of this s...

journal_title：Vaccine

authors： Sazzad HM,Rainey JJ,Mach O,Sutter R,Diordista S,Kawser CA,Mobarak R,Alam D,Chowdhury MA,Hossain MJ,Hasan AS,Luby SP

更新日期：2012-08-03 00:00:00

abstract：BACKGROUND:The hepatitis B surface antigen (HBsAg) has been administered over the last 20 years as a parenteral vaccine against the hepatitis B virus (HBV). Despite high seroconversion rates, chronic infection rates are still high worldwide. Orally delivered vaccines provide a practical alternative to injected vaccines...

journal_title：Vaccine

authors： Hayden CA,Fischer ME,Andrews BL,Chilton HC,Turner DD,Walker JH,Tizard IR,Howard JA

更新日期：2015-06-09 00:00:00

abstract：:West Nile virus (WNV) has caused multiple global outbreaks with increased frequency of neuroinvasive disease in recent years. Despite many years of research, there are no licensed therapeutics or vaccines available for human use. One of the major impediments of vaccine development against WNV is the potential enhancem...

journal_title：Vaccine

authors： Lai H,Paul AM,Sun H,He J,Yang M,Bai F,Chen Q

更新日期：2018-03-27 00:00:00

abstract：:The immunity levels against diphtheria, tetanus and poliomyelitis were investigated among blood donors (n = 2079) in Berlin. Of all participants, only 60% had full, long-term protection against diphtheria, 72% against tetanus, 87% against poliomyelitis type 1, 77% against poliomyelitis type 2 and 73% against type 3. T...

journal_title：Vaccine

authors： Stark K,Schönfeld C,Barg J,Molz B,Vornwald A,Bienzle U

更新日期：1999-02-26 00:00:00

abstract：:Safety of individuals at risk of immune suppression is an important concern for live vaccines. The new-generation tuberculosis vaccine candidate MTBVAC, a genetically engineered doubly attenuated Mycobacterium tuberculosis mutant with deletions in phoP and fadD26 virulence genes has demonstrated comparable safety in d...

journal_title：Vaccine

authors： Solans L,Uranga S,Aguilo N,Arnal C,Gomez AB,Monzon M,Badiola JJ,Gicquel B,Martin C

更新日期：2014-09-08 00:00:00

abstract：:It is generally recognized that DNA vaccines are often less effective in large animals than in mice. One possible reason for this reduced effectiveness may be transfection efficiency and the low level of expression elicited by plasmid vectors in large animals. A possible way to improve plasmid gene expression in vivo ...

journal_title：Vaccine

authors： Babiuk S,Baca-Estrada ME,Foldvari M,Storms M,Rabussay D,Widera G,Babiuk LA

更新日期：2002-09-10 00:00:00

abstract：:The distribution of alpha-casein, bovine serum albumin (BSA), myoglobin and recombinant protective antigen (rPA) in mono-valent and combination vaccines containing aluminum hydroxide adjuvant was studied by fluorescence microscopy and flow cytometry. Green and red fluorescent probes were conjugated to the antigens. Ad...

journal_title：Vaccine

authors： Morefield GL,HogenEsch H,Robinson JP,Hem SL

更新日期：2004-05-07 00:00:00

abstract：:A novel triterpenoidal saponin, called pulcherrimasaponin (CP05), isolated from the leaves of Calliandra pulcherrima Benth. shows remarkable similarities to the previously described potent adjuvant, QS21 saponin (Quillaja saponaria Molina). On the basis of chemical and physicochemical evidence, its structure was estab...

journal_title：Vaccine

authors： Silva BP,Soares JB,Souza EP,Palatnik M,Sousa CB,Parente JP

更新日期：2005-01-11 00:00:00

abstract：:The chloroplast genetic engineering offers a number of unique advantages including high level of transgene expression, multi-gene expression in single transformation event and transgene containment due to maternal inheritance. Hyper-expression of vaccine antigens or therapeutic proteins in transgenic chloroplasts (lea...

journal_title：Vaccine

authors： Daniell H,Chebolu S,Kumar S,Singleton M,Falconer R

更新日期：2005-03-07 00:00:00

abstract：BACKGROUND:Development of influenza vaccines that do not use embryonated eggs as the substrate for vaccine production is a high priority. We conducted this study to determine the protective efficacy a recombinant, baculovirus-expressed seasonal trivalent influenza virus hemagglutinin (rHA0) vaccine (FluBlok(®)). METHO...

journal_title：Vaccine

authors： Treanor JJ,El Sahly H,King J,Graham I,Izikson R,Kohberger R,Patriarca P,Cox M

更新日期：2011-10-13 00:00:00

abstract：:After introduction of a mono-component vaccine, containing only pertussis toxoid (PT), the incidence of pertussis was significantly higher in the Gothenburg area among children during the period October 1, 1997 until end of 2006 compared to the Rest of Sweden where a vaccine containing PT and two other pertussis antig...

journal_title：Vaccine

authors： Advani A,Gustafsson L,Ahrén C,Mooi FR,Hallander HO

更新日期：2011-04-18 00:00:00

abstract：:Anthrax vaccine adsorbed (AVA), an effective countermeasure against anthrax, is administered as six subcutaneous (SQ) doses over 18 months. To optimize the vaccination schedule and route of administration, we performed a prospective pilot study comparing the use of fewer AVA doses administered intramuscularly (IM) or ...

journal_title：Vaccine

authors： Pittman PR,Kim-Ahn G,Pifat DY,Coonan K,Gibbs P,Little S,Pace-Templeton JG,Myers R,Parker GW,Friedlander AM

更新日期：2002-01-31 00:00:00