Comparison of immunogenicity of recombinant and plasma derived hepatitis B antigen in guinea-pigs.

abstract：:We employed DNA shuffling and screening technologies to develop a single recombinant dengue envelope (E) antigen capable of inducing neutralizing antibodies against all four antigenically distinct dengue serotypes. By DNA shuffling of codon-optimized dengue 1-4 E genes, we created a panel of novel chimeric clones expr...

journal_title：Vaccine

authors： Apt D,Raviprakash K,Brinkman A,Semyonov A,Yang S,Skinner C,Diehl L,Lyons R,Porter K,Punnonen J

更新日期：2006-01-16 00:00:00

abstract：:The yield of influenza antigen production may significantly vary between vaccine strains; for example the A/California/07/09 (H1N1)-X179A vaccine virus, prepared during 2009 influenza pandemic, presented a low antigen yield in eggs compared to other seasonal H1N1 reassortants. In this study a bi-chimeric virus express...

journal_title：Vaccine

authors： Medina J,Boukhebza H,De Saint Jean A,Sodoyer R,Legastelois I,Moste C

更新日期：2015-08-20 00:00:00

abstract：:During the years 2009 and 2010 relevant epidemic waves of foot-and-mouth disease (FMD) serotype O occurred in Ecuador, representing a great drawback for the last stages of the ongoing eradication program in South America. This study describes the molecular and antigenic characterizations of 29 isolates collected from ...

journal_title：Vaccine

authors： Maradei E,Perez Beascoechea C,Malirat V,Salgado G,Seki C,Pedemonte A,Bonastre P,D'Aloia R,La Torre JL,Mattion N,Rodríguez Toledo J,Bergmann IE

更新日期：2011-10-26 00:00:00

abstract：:Several publications have reported recently the apparently successful use of human diploid cell rabies vaccine (HDCV) in volumes of less than the 6 X 1.0 cm3 dosage schedule currently recommended by the World Health Organization for post-exposure rabies prophylaxis. The newer proposed treatments are advocated to econo...

journal_title：Vaccine

authors： Gross EM,Bearman JE

更新日期：1985-09-01 00:00:00

abstract：:The efficacy of immunization of a vaccine depends on an antigen, an adjuvant, and on the expression of multiple genes in the host. The responsiveness of various strains of mice to adjuvants is therefore dependent on their genetic background present as a complex, multigenic trait similarly as in man. We have recently d...

journal_title：Vaccine

authors： Di Marco S,Moisan J,Boghdady ML,Skamene E,Radzioch D

更新日期：2003-02-14 00:00:00

abstract：:A National Immunization Technical Advisory Group (NITAG) is an expert advisory committee that provides evidence-based recommendations to the Ministry of Health (MoH) to guide immunization programs and policies. The World Health Organization (WHO), the Initiative for Supporting National Independent Immunization and Vac...

journal_title：Vaccine

authors： Blau J,Sadr-Azodi N,Clementz M,Abeysinghe N,Cakmak N,Duclos P,Janusz C,Jauregui B,Mihigo R,Mosina L,Takashima Y,Senouci K

更新日期：2013-05-28 00:00:00

abstract：PURPOSE:We conducted a cancer vaccine clinical trial with MAGE-A4 protein. Safety, clinical response, and antigen-specific immune responses were analyzed and the prognostic factors by vaccination were investigated. EXPERIMENTAL DESIGN:Twenty patients with advanced esophageal, stomach or lung cancer were administered M...

journal_title：Vaccine

authors： Saito T,Wada H,Yamasaki M,Miyata H,Nishikawa H,Sato E,Kageyama S,Shiku H,Mori M,Doki Y

更新日期：2014-10-14 00:00:00

abstract：:In this study, the potential price for a therapeutic vaccine against Human Papilloma Virus (HPV)-16 & 18 (pre)-malignant cervical lesions is examined. A decision tree model was built in the context of the new Dutch cervical cancer-screening program and includes a primary test for the presence of HPV. Based on data of ...

journal_title：Vaccine

authors： Luttjeboer J,Setiawan D,Cao Q,Cahh Daemen T,Postma MJ

更新日期：2016-12-07 00:00:00

abstract：:Fifty injecting drug users (IDUs) were recruited to evaluate the efficacy of an hepatitis B virus (HBV) vaccination campaign to be carried out in a Public centre for Drug Users (PCDU). The vaccination schedule was successfully performed in most patients, who showed a great interest in this problem. After three doses o...

journal_title：Vaccine

authors： Lugoboni F,Migliozzi S,Schiesari F,Pauletto N,Bovo GL,Ciaffoni S,Mezzelani P

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND:India has faced considerable challenges in eradicating polio. Uttar Pradesh (UP) and Bihar are the two states in India where transmission of polio has never been interrupted. Private pediatricians are important stakeholders for vaccine delivery and maintaining public confidence in vaccines. The purpose of th...

journal_title：Vaccine

authors： Choudhury P,Thacker N,Gargano LM,Weiss PS,Vashishtha VM,Amladi T,Pazol K,Orenstein WA,Omer SB,Hughes JM

更新日期：2011-10-26 00:00:00

abstract：:Fasciolosis continues to be a major cause of economic losses in the livestock industry and a growing threat to humans. The limited spectrum of effective anthelmintics and the appearance of resistances urge the need for developing an effective vaccine. Most studies have been focused on the use of TH1-polarizing adjuvan...

journal_title：Vaccine

authors： Orbegozo-Medina RA,Martínez-Sernández V,González-Warleta M,Castro-Hermida JA,Mezo M,Ubeira FM

更新日期：2018-04-05 00:00:00

abstract：:A novel triterpenoidal saponin, called pulcherrimasaponin (CP05), isolated from the leaves of Calliandra pulcherrima Benth. shows remarkable similarities to the previously described potent adjuvant, QS21 saponin (Quillaja saponaria Molina). On the basis of chemical and physicochemical evidence, its structure was estab...

journal_title：Vaccine

authors： Silva BP,Soares JB,Souza EP,Palatnik M,Sousa CB,Parente JP

更新日期：2005-01-11 00:00:00

abstract：:Streptococcus pneumoniae (pneumococcus) is responsible for significant morbidity and mortality in worldwide. After introduction of current pneumococcal vaccines, a marked decrease in the incidence of pneumococcal disease was observed. Unfortunately, serotype shifts in carriage and disease, including capsular switch an...

journal_title：Vaccine

authors： Kim EH,Choi SY,Kwon MK,Tran TD,Park SS,Lee KJ,Bae SM,Briles DE,Rhee DK

更新日期：2012-03-02 00:00:00

abstract：:The safety, reactogenicity and immunogenicity of three candidate Lyme vaccines based on recombinant outer surface protein (OspA) presented in either lipidated or unlipidated forms, were assessed in 300 seronegative volunteers. Subjects received three doses of one of the three formulations at monthly intervals and were...

journal_title：Vaccine

authors： Van Hoecke C,Comberbach M,De Grave D,Desmons P,Fu D,Hauser P,Lebacq E,Lobet Y,Voet P

更新日期：1996-12-01 00:00:00

abstract：:In Russia, live vaccine strains Brucella abortus 82 and B. abortus 75/79-AV have been widely and extensively utilized for specific prophylaxis of cattle brucellosis. To differentiate these vaccine strains from each other and laboratory collection of other vaccine (n=4), reference (n=15) and field Brucella strains (n=6...

journal_title：Vaccine

authors： Kulakov YK,Zheludkov MM,Sclyarov OD

更新日期：2010-10-01 00:00:00

abstract：:SOCS1-1 is crucial for control of immune cell cytokine expression, including those cytokines known to enable memory T-cell formation and homeostasis. In this study, we found that immunization with SOCS1-downregulated bone marrow-derived dendritic cells generated increased antigen-specific CD8(+) T memory cells and ant...

journal_title：Vaccine

authors： Aldrich M,Sanders D,Lapteva N,Huang XF,Chen SY

更新日期：2008-02-20 00:00:00

abstract：:The frequent outbreak of respiratory infectious diseases such as influenza and pulmonary tuberculosis calls for new immunization strategies with high effectiveness. Nasal immunization is one of the most potential methods to prevent the diseases infected through the respiratory tract. In this study, we designed a water...

journal_title：Vaccine

authors： Liu Q,Zhang C,Zheng X,Shao X,Zhang X,Zhang Q,Jiang X

更新日期：2014-05-07 00:00:00

abstract：:As a recently launched novel vaccine used as one of the vaccines for the final eradication of polios worldwide, complete data on the consistency and immunogenicity characteristics of the inactivated poliomyelitis vaccine made from the Sabin strain (sIPV) and its safety in large-scale populations are required to suppor...

journal_title：Vaccine

authors： Jiang R,Liu X,Sun X,Wang J,Huang Z,Li C,Li Z,Zhou J,Pu Y,Ying Z,Yin Q,Zhao Z,Zhang L,Lei J,Bao W,Jiang Y,Dou Y,Li J,Yang H,Cai W,Deng Y,Che Y,Shi L,Sun M

更新日期：2021-01-21 00:00:00

abstract：:A new strategy for designing synthetic vaccines is presented. In this approach synthetic peptides are conformationally restricted by replacing putative hydrogen bonds with covalent mimics. The chemistry for substituting a hydrazone-ethane link (N-N = CH-CH2-CH2) for an (i + 4)----i hydrogen bond in a pentapeptide with...

journal_title：Vaccine

authors： Satterthwait AC,Arrhenius T,Hagopian RA,Zavala F,Nussenzweig V,Lerner RA

更新日期：1988-04-01 00:00:00

abstract：:Consumed for centuries, lactic acid bacteria are excellent candidates for the development of safe mucosal delivery vehicles for prophylactic and therapeutic molecules. We have recently reported that the immune response to an effective OspA-expressing L. plantarum vaccine for Lyme disease is modulated by the lipid modi...

journal_title：Vaccine

authors： del Rio B,Fuente JL,Neves V,Dattwyler R,Seegers JF,Gomes-Solecki M

更新日期：2010-09-24 00:00:00

abstract：:Insoluble, nanostructured delta inulin particles enhance the immunogenicity of co-administered protein antigens and consequently are used as a vaccine adjuvant (Advax™). To better understand their immunomodulatory properties, the in vitro hydrolysis and in vivo distribution of delta inulin particles were investigated....

journal_title：Vaccine

authors： Wang L,Barclay T,Song Y,Joyce P,Sakala IG,Petrovsky N,Garg S

更新日期：2017-08-03 00:00:00

abstract：:'Children represent the most vulnerable segment of every society--and they are our present and future. Good health, especially of children, promotes personal and national development. Scientific progress, matched with improved capacities of all countries to immunize their children, provides an unparalleled opportunity...

journal_title：Vaccine

authors： van Noort RB

更新日期：1992-01-01 00:00:00

abstract：:Pandemic outbreaks of influenza are caused by the emergence of a pathogenic and transmissible virus to which the human population is immunologically naïve. Recent outbreaks of highly pathogenic avian influenza (HPAI) of the H5N1 subtype are of particular concern because of the high mortality rate (60% case fatality ra...

journal_title：Vaccine

authors： Giles BM,Ross TM

更新日期：2011-04-05 00:00:00

abstract：BACKGROUND:Concern arose in 2010 that reactogenicity, particularly febrile seizures, to influenza A/H1N1-containing 2010-2011 trivalent seasonal inactivated influenza vaccine (TIV) could occur in young children who had been previously immunized and/or infected with the pandemic strain. We conducted a pre-season study o...

journal_title：Vaccine

authors： Langley JM,Scheifele DW,Quach C,Vanderkooi OG,Ward B,McNeil S,Dobson S,Kellner JD,Kuhn S,Kollman T,MacKinnon-Cameron D,Smith B,Li Y,Halperin SA

更新日期：2012-05-14 00:00:00

abstract：BACKGROUND:Between 2007 and 2011 the Netherlands was faced with an unprecedented Q fever outbreak with more than 4000 people affected. Dairy goats were considered the main source of infection. In addition to taking veterinary measures, the Dutch government offered an unlicensed vaccine against the causative bacterium C...

journal_title：Vaccine

authors： Isken LD,Kraaij-Dirkzwager M,Vermeer-de Bondt PE,Rümke HC,Wijkmans C,Opstelten W,Timen A

更新日期：2013-05-28 00:00:00

abstract：:Respiratory syncytial virus (RSV) is a leading viral cause of respiratory morbidity and mortality in infants and young children worldwide. Low and middle income countries (LMICs) account for approximately 99% of the global mortality estimates in this population, with up to 200,000 RSV deaths per year. The vaccine prod...

journal_title：Vaccine

authors： Giersing BK,Karron RA,Vekemans J,Kaslow DC,Moorthy VS

更新日期：2019-11-28 00:00:00

abstract：:Seasonal influenza epidemics represent a substantial public health burden, causing significant morbidity and mortality. Influenza in humans can be caused by influenza type A and type B viruses, and although influenza A is responsible for the majority of seasonal influenza infections, influenza B disease is common in c...

journal_title：Vaccine

authors： Belshe RB

更新日期：2010-09-07 00:00:00

abstract：:The membrane proximal region (MPR) of HIV-1 gp41 is a desirable target for development of a vaccine that elicits neutralizing antibodies since the patient-derived monoclonal antibodies, 2F5 and 4E10, bind to the MPR and neutralize primary HIV isolates. The 2F5 and 4E10 antibodies cross-react with lipids and structural...

journal_title：Vaccine

authors： Watson DS,Szoka FC Jr

更新日期：2009-07-23 00:00:00

abstract：:Obesity is a risk factor for complicated influenza A/H1N1 disease and poor vaccine immunogenicity. Leptin, an adipocyte-derived hormone/cytokine, has many immune regulatory functions and therefore could explain susceptibility to infections and poor vaccine outcomes. We recruited 159 healthy adults (50-74 years old) wh...

journal_title：Vaccine

authors： Ovsyannikova IG,White SJ,Larrabee BR,Grill DE,Jacobson RM,Poland GA

更新日期：2014-02-07 00:00:00

abstract：:Hemagglutinin, the major surface protein of influenza viruses, was recombinantly expressed in eukaryotic cells as a monomer instead of its native trimer, and was only immunogenic when administered with an adjuvant [Pion et al. 2014]. In order to multimerize this antigen to increase its immunogenicity, a cysteine-rich ...

journal_title：Vaccine

authors： Peubez I,Margot S,Buffin S,Pion C,Bernard MC,Dinadayala P,Poncet D,Deloire S,Marco S,Legastelois I

更新日期：2020-11-25 00:00:00