Abstract：
:The efficacy of immunization of a vaccine depends on an antigen, an adjuvant, and on the expression of multiple genes in the host. The responsiveness of various strains of mice to adjuvants is therefore dependent on their genetic background present as a complex, multigenic trait similarly as in man. We have recently developed a gene-discovery platform, termed recombinant congenic strains (RCS), that greatly facilitates the dissection, localization and characterization of genes that mediate complex traits such as responsiveness to adjuvants. These recombinant congenic mice, which were constructed from two progenitor strains (A/J and C57BL/6) that are phenotypically different for several spontaneous or infectious diseases, were generated such that they carry 13.5% of the one genome in 85% of the other genome. The use of these RCS mice therefore enables a more efficient identification of genes that mediate the responsiveness of the adjuvant.
journal_name
Vaccinejournal_title
Vaccineauthors
Di Marco S,Moisan J,Boghdady ML,Skamene E,Radzioch Ddoi
10.1016/s0264-410x(02)00528-5subject
Has Abstractpub_date
2003-02-14 00:00:00pages
832-5issue
9-10eissn
0264-410Xissn
1873-2518pii
S0264410X02005285journal_volume
21pub_type
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