Abstract：
:Respiratory syncytial virus causes a significant public health burden, particularly in very young infants and the frail elderly. The legacy of enhanced RSV disease (ERD) from a whole formalin-inactivated RSV vaccine, and the complex biology of the virus and the neonate have delayed the development of effective vaccines. However, new insights into factors associated with ERD and breakthroughs in understanding the antigenic structure of the fusion (F) glycoprotein have increased optimism that vaccine development is possible. This has led to investment of time and resources by industry, regulatory authorities, governments, and nonprofit organizations to develop the infrastructure needed to make the advanced clinical development of RSV vaccine candidates a reality.
journal_name
Vaccinejournal_title
Vaccineauthors
Graham BSdoi
10.1016/j.vaccine.2016.04.083subject
Has Abstractpub_date
2016-06-24 00:00:00pages
3535-41issue
30eissn
0264-410Xissn
1873-2518pii
S0264-410X(16)30257-2journal_volume
34pub_type
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