Abstract：
:DNA isolates from a number of established cell lines have been tested for their transforming capacity in the NIH3T3 transformation assay. It has been found that this assay can be used to quantify the amount of transforming DNA at a submicrogram to milligram level. This assay system has been applied to validate the reduction of transforming DNA in various purification steps of cell culture products. The NIH3T3 assay system has been shown useful for in-process control and release of cell culture derived vaccines or therapeutics.
journal_name
Vaccinejournal_title
Vaccineauthors
van Meel FC,Steenbakkers PG,Bos Edoi
10.1016/0264-410x(85)90126-4subject
Has Abstractpub_date
1985-12-01 00:00:00pages
375-8issue
5eissn
0264-410Xissn
1873-2518pii
0264-410X(85)90126-4journal_volume
3pub_type
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