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Immunization of livestock with DNA vaccines: current studies and future prospects.

Abstract：

:Early studies using DNA immunization suggest the potential benefits of this form of immunization including: long-lived immunity, a broad spectrum of immune responses (both cell-mediated immunity and humoral responses) and the simultaneous induction of immunity to a variety of pathogens through the use of multivalent vaccines. Using marine and cow models, we studied methods to enhance and direct the immune response to polynucleotide vaccines. We demonstrated the ability to modulate the magnitude and direction of the immune response by co-administration of plasmid encoded cytokines and antigen. Also, we clearly demonstrated that the cellular components (cytosolic, membrane-anchored, or extracellular) to which the expressed antigen is delivered determines the types of immune responses induced. Since induction of immunity at mucosal surfaces (route of entry for many pathogens) is critical to prevent infection, various methods of delivering polynucleotide vaccines to animals including mucosal surfaces have been attempted and are described as future prospects for improving immune responses by DNA vaccination.

journal_name

Vaccine

journal_title

Vaccine

authors

van Drunen Littel-van den Hurk S,Loehr BI,Babiuk LA

doi

10.1016/s0264-410x(00)00476-x

subject

Has Abstract

pub_date

2001-03-21 00:00:00

pages

2474-9

issue

17-19

eissn

0264-410X

issn

1873-2518

pii

S0264410X0000476X

journal_volume

19

pub_type

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