Abstract：
:Antibodies have the potential to be therapeutic reagents for malaria. Here we describe the production of a novel phage antibody display library against the C-terminal 19kDa region of the Plasmodium yoelii YM merozoite surface protein-1 (MSP1(19)). In vivo studies against homologous lethal malaria challenge show an anti-parasite effect in a dose dependent manner, and analysis by plasmon resonance indicates binding to the antigen is comparable to the binding of a protective monoclonal antibody. The data support the lack of a need for any antibody Fc-related function and hold great significance for the development of a therapeutic reagent for malaria.
journal_name
Vaccinejournal_title
Vaccineauthors
Vukovic P,Chen K,Qin Liu X,Foley M,Boyd A,Kaslow D,Good MFdoi
10.1016/s0264-410x(02)00197-4subject
Has Abstractpub_date
2002-06-21 00:00:00pages
2826-35issue
21-22eissn
0264-410Xissn
1873-2518pii
S0264410X02001974journal_volume
20pub_type
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