Antibodies against Haemophilus influenzae type b in The Gambia: investigating the extent of protection across age groups.


:Following a landmark clinical trial, the vaccine against Haemophilus influenzae type b (Hib) was introduced in The Gambia in 1997. Whilst the immunogenicity of this vaccine is well established subsequent to the doses administered under the EPI schedule, little data exists assessing longevity of protection, using serology. Such data are needed however to predict the susceptibility to Hib at the population level. To determine antibody persistence in 5-6 year old fully vaccinated Gambian children compared with older children, adolescents and young adults, 427 serum samples from healthy 5-37 year old participants were tested for Hib antibodies using VaccZyme Human Anti-Hib ELISA kits. 86% of the children who had received 3 doses of Hib vaccine in infancy had Hib antibody concentrations ≥0.15 mg/l at the age of 5-6 years. This proportion was 76% for adolescents who had also largely been vaccinated and 90% for adults who had never received Hib vaccine. Although most participants had anti-Hib antibody above concentrations putatively defined as protective, significantly fewer had concentrations thought to confer long-term protection. This suggests a population with insufficient or waning antibody that may be susceptible to breakthrough disease and transmission.






Idoko OT,Roberts E,Cox M,Jafali J,Njie-Jobe J,Mackenzie G,Ota MO,Kampmann B




Has Abstract


2014-08-06 00:00:00
















  • Antibody and T-cell responses to a virosomal adjuvanted H9N2 avian influenza vaccine: impact of distinct additional adjuvants.

    abstract::A highly efficacious vaccine is required to counteract a threat of an avian influenza pandemic. Increasing the potency of vaccines by adjuvation is essential not only to overcome generally low immunogenicity of pandemic strains, but also to allow dose sparing and as such to make it feasible to satisfy huge global prod...


    pub_type: 杂志文章


    authors: Radosević K,Rodriguez A,Mintardjo R,Tax D,Bengtsson KL,Thompson C,Zambon M,Weverling GJ,Uytdehaag F,Goudsmit J

    更新日期:2008-07-04 00:00:00

  • Understanding vaccination resistance: vaccine search term selection bias and the valence of retrieved information.

    abstract:CONTEXT:Dubious vaccination-related information on the Internet leads some parents to opt out of vaccinating their children. OBJECTIVES:To determine if negative, neutral and positive search terms retrieve vaccination information that differs in valence and confirms searchers' assumptions about vaccination. METHODS:A ...


    pub_type: 杂志文章


    authors: Ruiz JB,Bell RA

    更新日期:2014-10-07 00:00:00

  • Safety and immunogenicity of 23-valent pneumococcal polysaccharide vaccine in HIV-1 infected former drug users.

    abstract::The immunogenicity of 23-valent pneumococcal polysaccharide vaccine was assessed in 57 HIV-1 infected former intravenous drug users and in 20 HIV-1 negative controls. The effect of vaccination on HIV-1 infection was studied in a subgroup of 38 patients, 60% of whom under highly active antiretroviral therapy (HAART). A...


    pub_type: 杂志文章


    authors: Amendola A,Tanzi E,Zappa A,Colzani D,Boschini A,Musher DM,Zanetti AR

    更新日期:2002-11-01 00:00:00

  • Global Vaccine Action Plan Lessons Learned II: Stakeholder Perspectives.

    abstract:INTRODUCTION:The Global Vaccine Action Plan (GVAP), unanimously endorsed by the World Health Assembly in 2012, defined an ambitious strategy to improve immunization. At the end of the decade, significant progress has been made but four of the five GVAP goals are likely to be missed. This report describes a set of surve...


    pub_type: 杂志文章


    authors: Hwang A,Veira C,Malvolti S,Cherian T,MacDonald N,Steffen C,Jones I,Hinman A,Mantel C

    更新日期:2020-07-14 00:00:00

  • Use of rubella seroepidemiological data for assessment of previous vaccination policy and for decision making in response to epidemics in Israel.

    abstract::We examined the prevalence of rubella antibodies in a representative sample of the Israeli population. Three thousand three hundred and twenty-six sera collected during 1997 and 1998, from an age-stratified general population sample were tested for specific IgG antibodies against rubella. The sero-positivity rates to ...


    pub_type: 杂志文章


    authors: Cohen D,Muhsen Kh,Aboudy Y,Harari H,Mendelson E,Green MS

    更新日期:2006-07-07 00:00:00

  • Impact of a mixed bacterial lysate (OM-85 BV) on the immunogenicity, safety and tolerability of inactivated influenza vaccine in children with recurrent respiratory tract infection.

    abstract::It is known that the immunogenicity and efficacy of conventional inactivated influenza vaccines (IIVs) are not completely satisfactory in children. The aim of this prospective, randomised, single-blind study was to compare the immune response to, and the effectiveness and safety of, an IIV (Fluarix, GlaxoSmithKline Bi...


    pub_type: 杂志文章,随机对照试验


    authors: Esposito S,Marchisio P,Prada E,Daleno C,Porretti L,Carsetti R,Bosco A,Ierardi V,Scala A,Principi N

    更新日期:2014-05-07 00:00:00

  • Induction of mucosal immunity with a replication-defective adenoviral recombinant.

    abstract::A replication-defective adenoviral recombinant expressing the rabies virus glycoprotein was tested for induction of transgene specific central and mucosal antibodies upon systemic inoculation or upon application to the mucosa of the airways, the rectum or the female genital tract. Mice developed serum and mucosal anti...


    pub_type: 杂志文章


    authors: Xiang Z,Ertl HC

    更新日期:1999-04-09 00:00:00

  • Algammulin, a new vaccine adjuvant comprising gamma inulin particles containing alum: preparation and in vitro properties.

    abstract::Crystallization of inulin with alum forms a fine (1-2 micron) suspension of electron-dense ovoids; the alum is embedded in inulin particles, which are then converted to the immune stimulant polymorphic form, gamma inulin. This very stable hybrid preparation is termed Algammulin. Preferred conditions for its preparatio...


    pub_type: 杂志文章


    authors: Cooper PD,Steele EJ

    更新日期:1991-05-01 00:00:00

  • Profiling of the antibody response to attenuated LC16m8 smallpox vaccine using protein array analysis.

    abstract::Concerns about bioterrorism and outbreaks of zoonotic orthopoxvirus require safe and efficacious smallpox vaccines. We previously reported the clinical efficacy and safety profiles of LC16m8, a live, attenuated, cell culture-derived, smallpox vaccine, examined in over 3000 healthy Japanese adults with various vaccinat...


    pub_type: 杂志文章


    authors: Eto A,Fujita M,Nishiyama Y,Saito T,Molina DM,Morikawa S,Saijo M,Shinmura Y,Kanatani Y

    更新日期:2019-10-16 00:00:00

  • Generation of recombinant pandemic H1N1 influenza virus with the HA cleavable by bromelain and identification of the residues influencing HA bromelain cleavage.

    abstract::The proteolytic enzyme bromelain has been traditionally used to cleave the hemagglutinin (HA) protein at the C-terminus of the HA2 region to release the HA proteins from influenza virions. The bromelain cleaved HA (BHA) has been routinely used as an antigen to generate antiserum that is essential for influenza vaccine...


    pub_type: 杂志文章


    authors: Wang W,Suguitan AL Jr,Zengel J,Chen Z,Jin H

    更新日期:2012-01-20 00:00:00

  • Leprosy--in pursuit of a vaccine.

    abstract::Clinical leprosy is characterized by varying manifestations between tuberculoid and lepromatous leprosy. In the former state the patient is able to elicit a cell-mediated immune response whereas in the latter, there is usually a humoral response. An understanding of this immunological balance is crucial in the search ...


    pub_type: 历史文章,杂志文章,评审


    authors: Stewart-Tull DE

    更新日期:1984-12-01 00:00:00

  • Understanding differences in predictions of HPV vaccine effectiveness: A comparative model-based analysis.

    abstract::Mathematical models of HPV vaccine effectiveness and cost-effectiveness have produced conflicting results. The aim of this study was to use mathematical models to compare and isolate the impact of the assumptions most commonly made when modeling the effectiveness of HPV vaccines. Our results clearly show that differen...


    pub_type: 杂志文章


    authors: Van de Velde N,Brisson M,Boily MC

    更新日期:2010-07-26 00:00:00

  • The bovine viral diarrhea virus E2 protein formulated with a novel adjuvant induces strong, balanced immune responses and provides protection from viral challenge in cattle.

    abstract::Bovine viral diarrhea virus (BVDV) is still one of the most serious pathogens in cattle, meriting the development of improved vaccines. Recently, we developed a new adjuvant consisting of poly[di(sodium carboxylatoethylphenoxy)]-phosphazene (PCEP), either CpG ODN or poly(I:C), and an immune defense regulator (IDR) pep...


    pub_type: 杂志文章


    authors: Snider M,Garg R,Brownlie R,van den Hurk JV,van Drunen Littel-van den Hurk S

    更新日期:2014-11-28 00:00:00

  • A randomized, placebo-controlled study of oral cimetidine as an immunopotentiator of parenteral immunization with a group B meningococcal vaccine.

    abstract::Cimetidine (CIM) is an H2-receptor antagonist with a long history of clinical use in peptic ulcer disease. In addition to its inhibitory effect upon gastric acid secretion, CIM can also block histamine-mediated immunosuppression by inhibiting H2 receptors on suppressor T cells. CIM results in immunoaugmentation of bot...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Drabick JJ,Tang DB,Moran EE,Trofa AF,Foster JS,Zollinger WD

    更新日期:1997-07-01 00:00:00

  • Safety and immunogenicity of a new formulation of an inactivated hepatitis A vaccine.

    abstract::The safety and immunogenicity of a new formulation of the inactivated hepatitis A vaccine, Avaxim, was evaluated in 189 children, aged 18 months to 15 years in a monocentric, open trial. Two vaccinations were given six months apart. Enrollment was balanced within three age groups: 18 months to 3 years, 4-8 years and 9...


    pub_type: 临床试验,杂志文章


    authors: Dagan R,Greenberg D,Goldenbertg-Gehtman P,Vidor E,Briantais P,Pinsk V,Athias O,Dumas R

    更新日期:1999-04-09 00:00:00

  • A randomized study of fever prophylaxis and the immunogenicity of routine pediatric vaccinations.

    abstract:OBJECTIVE:Prophylactic antipyretic use during pediatric vaccination is common. This study assessed whether paracetamol or ibuprofen prophylaxis interfere with immune responses to the 13-valent pneumococcal conjugate vaccine (PCV13) given concomitantly with the combined DTaP/HBV/IPV/Hib vaccine. METHODS:Subjects receiv...


    pub_type: 杂志文章,随机对照试验


    authors: Wysocki J,Center KJ,Brzostek J,Majda-Stanislawska E,Szymanski H,Szenborn L,Czajka H,Hasiec B,Dziduch J,Jackowska T,Witor A,Kopińska E,Konior R,Giardina PC,Sundaraiyer V,Patterson S,Gruber WC,Scott DA,Gurtman A

    更新日期:2017-04-04 00:00:00

  • Systematic review of the effects of pertussis vaccines in children.

    abstract:OBJECTIVE:To assess the efficacy and safety of whole-cell and acellular pertussis vaccines administered to children singly or within diphtheria, tetanus and pertussis (DTP) vaccines. DATA SOURCES:We searched the Cochrane Library, MEDLINE, EMBASE, Biological Abstracts and Science Citation Index to December 2001. Specia...


    pub_type: 杂志文章,评审


    authors: Jefferson T,Rudin M,DiPietrantonj C

    更新日期:2003-05-16 00:00:00

  • Evaluation of protection in a mouse model after vaccination with Mycobacterium avium subsp. paratuberculois protein cocktails.

    abstract::Whole-cell vaccines successfully reduce signs of clinical disease and fecal shedding of Mycobacterium avium subsp. paratuberculosis (MAP), however, these vaccines have some limitations. The present study was conducted to identify MAP proteins that might be candidates for the development of an improved vaccine. MAP pro...


    pub_type: 杂志文章


    authors: Stabel JR,Barnhill A,Bannantine JP,Chang YF,Osman MA

    更新日期:2012-12-17 00:00:00

  • DNA vaccine with α-galactosylceramide at prime phase enhances anti-tumor immunity after boosting with antigen-expressing dendritic cells.

    abstract::DNA vaccines contribute to a promising new approach for the generation of cytotoxic T lymphocytes (CTL). DNA vaccines do have several disadvantages, including poor immunogenicity and oncogene expression. We used the natural killer T-cell (NKT) ligand α-galactosylceramide (α-GalCer) as an adjuvant to prime initial DNA ...


    pub_type: 杂志文章


    authors: Kim D,Hung CF,Wu TC,Park YM

    更新日期:2010-10-21 00:00:00

  • Immunity to rubella before and after vaccination against measles, mumps and rubella (MMR) at 12 years of age of the first generation offered MMR vaccination in Sweden at 18 months.

    abstract::In 1982, a two-dose programme of vaccination against measles, mumps and rubella (MMR) at the ages of 18 months and 12 years was introduced in Sweden. In 1992-3, the first group of children vaccinated at 18 months reached the age of 12, i.e. the time for a second dose. In connection with this 12-year vaccination, 376 c...


    pub_type: 杂志文章,多中心研究


    authors: Böttiger M

    更新日期:1995-12-01 00:00:00

  • UV-inactivated vaccinia virus (VV) in a multi-envelope DNA-VV-protein (DVP) HIV-1 vaccine protects macaques from lethal challenge with heterologous SHIV.

    abstract::The pandemic of HIV-1 has continued for decades, yet there remains no licensed vaccine. Previous research has demonstrated the effectiveness of a multi-envelope, multi-vectored HIV-1 vaccine in a macaque-SHIV model, illustrating a potential means of combating HIV-1. Specifically, recombinant DNA, vaccinia virus (VV) a...


    pub_type: 杂志文章


    authors: Jones BG,Sealy RE,Zhan X,Freiden PJ,Surman SL,Blanchard JL,Hurwitz JL

    更新日期:2012-05-02 00:00:00

  • The effect of immunization on chemokines and CCR5 and CXCR4 coreceptor functions in SIV binding and chemotaxis.

    abstract::The replication of simian immunodeficiency virus (SIV) in acutely infected CD4+ cells can be inhibited in vitro by CD8-suppressor factors (SF) and beta-chemokines induced by immunization of macaques with SIV gp120 and p27 in Alum. A comparison between intradermal, naso-rectal-i.m. and targeted iliac lymph node (TILN) ...


    pub_type: 杂志文章


    authors: Wang Y,Tao L,Mitchell E,Bergmeier L,Doyle C,Lehner T

    更新日期:1999-04-09 00:00:00

  • Cost-effectiveness of adult vaccinations: A systematic review.

    abstract:BACKGROUND:Coverage levels for many recommended adult vaccinations are low. The cost-effectiveness research literature on adult vaccinations has not been synthesized in recent years, which may contribute to low awareness of the value of adult vaccinations and to their under-utilization. We assessed research literature ...


    pub_type: 杂志文章


    authors: Leidner AJ,Murthy N,Chesson HW,Biggerstaff M,Stoecker C,Harris AM,Acosta A,Dooling K,Bridges CB

    更新日期:2019-01-07 00:00:00

  • Expression profiles of inflammatory and immune-related genes in Atlantic salmon (Salmo salar L.) at early time post vaccination.

    abstract::Vaccination of Atlantic salmon parr with oil-based vaccines will inevitably cause inflammation at the site of injection, albeit the underlying mechanisms are not very well understood or studied in any detail. Here, we report time-course changes in expression levels, assessed by real-time RT-PCR of IL-1 beta, Mx, two b...


    pub_type: 杂志文章


    authors: Haugland O,Torgersen J,Syed M,Evensen O

    更新日期:2005-12-01 00:00:00

  • SIV vaccines: current status. The role of the SIV-macaque model in AIDS research.

    abstract::SIV vaccines made of inactivated whole virus, modified live virus and native and recombinant envelope antigens have protected macaques against experimental infection with low doses of cell-free SIV given systemically. The few vaccinated monkeys that do become infected have tended to live longer than the infected contr...


    pub_type: 杂志文章,评审


    authors: Gardner M

    更新日期:1991-11-01 00:00:00

  • Identification of murine T-cell epitopes on low-molecular-mass secretory proteins (CFP11, CFP17, and TB18.5) of Mycobacterium tuberculosis.

    abstract::The low-molecular-mass secretory proteins of Mycobacterium tuberculosis have been shown to be major T-cell antigens during infection with the pathogenic bacterium. In this study, we determined murine T-cell epitopes on three low-molecular-mass proteins, CFP11 (Rv2433c), CFP17 (Rv1827), and TB18.5 (Rv0164) using DNA im...


    pub_type: 杂志文章


    authors: Eweda G,Suzuki D,Nagata T,Tsujimura K,Koide Y

    更新日期:2010-06-23 00:00:00

  • Biodegradable microspheres as controlled-release tetanus toxoid delivery systems.

    abstract::Purified tetanus toxoid, a high-molecular-weight protein, was entrapped within poly(L-lactic acid) (PLA) and poly(D,L-lactic/glycolic acid) (PLGA) microspheres prepared by either a solvent extraction or a solvent evaporation method carried out in a multiple emulsion system (water-in-oil-in-water). The physical integri...


    pub_type: 杂志文章


    authors: Alonso MJ,Gupta RK,Min C,Siber GR,Langer R

    更新日期:1994-03-01 00:00:00

  • Phase I study of detoxified Escherichia coli J5 lipopolysaccharide (J5dLPS)/group B meningococcal outer membrane protein (OMP) complex vaccine in human subjects.

    abstract::We previously observed that a detoxified Escherichia coli O111, Rc chemotype J5 lipopolysaccharide (J5dLPS)/group B meningococcal outer membrane protein (OMP) vaccine protected animals from experimental lethal sepsis when immune antibodies were given passively as treatment at the onset of fever or when vaccine was giv...


    pub_type: 临床试验,杂志文章


    authors: Cross AS,Opal SM,Palardy JE,Drabick JJ,Warren HS,Huber C,Cook P,Bhattacharjee AK

    更新日期:2003-11-07 00:00:00

  • Recombinant hemagglutinin protein of rinderpest virus expressed in insect cells induces humoral and cell mediated immune responses in cattle.

    abstract::Rinderpest virus causes a highly contagious and often fatal disease in domestic and wild ruminants. The surface glycoproteins, hemagglutinin (H) and fusion (F) proteins of this enveloped virus are known to confer protective immunity in cattle. We have reported the generation of a recombinant baculovirus expressing H p...


    pub_type: 杂志文章


    authors: Sinnathamby G,Naik S,Renukaradhya GJ,Rajasekhar M,Nayak R,Shaila MS

    更新日期:2001-07-16 00:00:00

  • Determinants of under-immunization and cumulative time spent under-immunized in a Quebec cohort.

    abstract:BACKGROUND:Under-immunization refers to a state of sub-optimal protection against vaccine preventable diseases. Vaccine coverage for age may not capture intentional or non-intentional spacing of vaccines in the recommended provincial immunization guidelines. We aimed to identify factors associated with coverage and und...


    pub_type: 杂志文章


    authors: O'Donnell S,Dubé E,Tapiero B,Gagneur A,Doll MK,Quach C

    更新日期:2017-10-13 00:00:00