Incidence of severe Plasmodium falciparum malaria as a primary endpoint for vaccine efficacy trials in Bandiagara, Mali.

abstract：:The vast majority of vaccines used throughout the world are supplied by the private sector. It is essential therefore that the industry is closely engaged in future policy developments at a national and international level and is able to respond to the changing needs and priorities that may be required to ensure the s...

journal_title：Vaccine

authors： Almond J,Medaglini D

更新日期：2017-01-20 00:00:00

abstract：BACKGROUND:The relative importance of different attitudes in predicting vaccination among healthcare personnel (HCP) is unclear. We hypothesized that HCP who feel at risk without vaccination or say they would regret not getting vaccinated would be more likely to get vaccinated than HCP who do not expect these emotional...

journal_title：Vaccine

authors： Thompson MG,Gaglani MJ,Naleway A,Ball S,Henkle EM,Sokolow LZ,Brennan B,Zhou H,Foster L,Black C,Kennedy ED,Bozeman S,Grohskopf LA,Shay DK

更新日期：2012-05-21 00:00:00

abstract：:The need to avoid using primates has prompted the replacement of primary monkey kidney cells (PMKC) as a substrate for oral polio vaccine (OPV) production. Here, we report on OPV produced on MRC-5 cells using an industrial process capable of producing over 1 billion doses. All serotypes produced on MRC-5 cells proved ...

journal_title：Vaccine

authors： Prikazsky V,Leroux-Roels G,Van Damme P,Safary A,Colau B,Duchene M

更新日期：2005-07-21 00:00:00

abstract：:The aim was to develop T cell costimulatory molecules that are broadly applicable to augment anti-tumor immune responses upon application of a virus-modified tumor vaccine to cancer patients. We generated recombinant bispecific single-chain antibodies with one specificity directed against the CD3 or the CD28 antigen o...

journal_title：Vaccine

authors： Haas C,Lulei M,Fournier P,Arnold A,Schirrmacher V

更新日期：2005-03-31 00:00:00

abstract：:We tested whether pilus proteins of rabbit diarrhoeagenic Escherichia coli (RDEC-1), incorporated into biodegradable microspheres, could function as safe and effective oral immunogens in the rabbit diarrhoea model. The RDEC-1 adhesin, AF/R1, incorporated into poly(D,L-lactide-co-glycolide) microspheres, was administer...

journal_title：Vaccine

authors： McQueen CE,Boedeker EC,Reid R,Jarboe D,Wolf M,Le M,Brown WR

更新日期：1993-01-01 00:00:00

abstract：:The protective effect of purified human immunoglobulin against human T-cell leukaemia virus type I (HTLV-I), designated ATLIG on HTLV-I infection was examined in cynomolgus monkeys (Macaca fascicularis) as a preclinical study. Passive immunization of ATLIG 24 h before challenging HTLV-I protected the monkeys from HTLV...

journal_title：Vaccine

authors： Akari H,Suzuki T,Ikeda K,Hoshino H,Tomono T,Murotsuka T,Terao K,Ito H,Yoshikawa Y

更新日期：1997-08-01 00:00:00

abstract：:DNA immunization with HIV envelope plasmids induce only moderate levels of specific antibodies which may in part be due to limitations in expression influenced by a species-specific and biased HIV codon usage. We compared antibody levels, Th1/Th2 type and CTL responses induced by synthetic genes encoding membrane boun...

journal_title：Vaccine

authors： Vinner L,Nielsen HV,Bryder K,Corbet S,Nielsen C,Fomsgaard A

更新日期：1999-04-23 00:00:00

abstract：BACKGROUND:Human papillomavirus (HPV) vaccines have been recommended as primary prevention of HPV-related cancers for over 10 years in the United States, and evidence reveals decreased incidence of HPV infections following vaccination. However, concerns have been raised that HPV vaccines could decrease fertility. This ...

journal_title：Vaccine

authors： Schmuhl NB,Mooney KE,Zhang X,Cooney LG,Conway JH,LoConte NK

更新日期：2020-05-19 00:00:00

abstract：:A new strategy for designing synthetic vaccines is presented. In this approach synthetic peptides are conformationally restricted by replacing putative hydrogen bonds with covalent mimics. The chemistry for substituting a hydrazone-ethane link (N-N = CH-CH2-CH2) for an (i + 4)----i hydrogen bond in a pentapeptide with...

journal_title：Vaccine

authors： Satterthwait AC,Arrhenius T,Hagopian RA,Zavala F,Nussenzweig V,Lerner RA

更新日期：1988-04-01 00:00:00

abstract：:Vaccination is an effective strategy to prevent pneumococcal diseases. Currently, licensed vaccines include the pneumococcal polysaccharide vaccine (PPSV) and the pneumococcal conjugate vaccine (PCV), which target some of the most common of the 94 serotypes of S. pneumoniae based on their capsular composition. However...

journal_title：Vaccine

authors： Nagai K,Domon H,Maekawa T,Hiyoshi T,Tamura H,Yonezawa D,Habuka R,Saitoh A,Terao Y

更新日期：2019-01-03 00:00:00

abstract：:Behcet's disease (BD) is a chronic, recurrent, inflammatory, multisystemic disorder characterized primarily by vasculitis. The etiopathogenesis of BD involves immunogenetics, infectious organisms (streptococcus, herpes simplex virus), immunoregulation and vascular dysfunctions. We previously found that immunoregulatio...

journal_title：Vaccine

authors： Lee SI,Kwon HJ,Lee ES,Yang BC,Bang D,Lee S,Sohn S

更新日期：2007-10-10 00:00:00

abstract：:The unique genetic makeup and remarkable competency of Vibrio cholerae are the key factors that help the cholera pathogen adapt rapidly to adverse environmental conditions and resist the detrimental effect of antimicrobial agents. In the last few decades, V. cholerae that causes acute watery diarrhoeal disease cholera...

journal_title：Vaccine

authors： Das B,Verma J,Kumar P,Ghosh A,Ramamurthy T

更新日期：2020-02-29 00:00:00

abstract：:Vaccine refusal has an impact on public health, and the human pappillomavirus (HPV) vaccine is particularly underutilized. Research suggests that it may be difficult to change vaccine-related attitudes, and there is currently no good evidence to recommend any particular intervention strategy. One reason for vaccine he...

journal_title：Vaccine

authors： Scherer LD,Shaffer VA,Patel N,Zikmund-Fisher BJ

更新日期：2016-05-05 00:00:00

abstract：BACKGROUND:World Health Organization has recommended the introduction of pneumococcal conjugate vaccine (PCV) in the childhood immunisation programme of all the countries in the world. In lieu of its introduction in India, there is a need to generate evidence on cost-effectiveness of this vaccine. The current study loo...

journal_title：Vaccine

authors： Krishnamoorthy Y,Eliyas SK,Nair NP,Sakthivel M,Sarveswaran G,Chinnakali P

更新日期：2019-01-21 00:00:00

abstract：:Reaseheath line C chicks produced IgA, IgG and IgM in their serum, tears, spleen and Harderian gland (HG) as a consequence of oculotopical vaccination with the Hitchner B1 strain of Newcastle disease virus. The IgM response was seen first, at 5 days after vaccination, and antiviral IgM levels in the tears and serum we...

journal_title：Vaccine

authors： Russell PH,Ezeifeka GO

更新日期：1995-01-01 00:00:00

abstract：:Prior work shows that an attenuated West Nile virus (WNV), the nonstructural (NS)4B-P38G mutant infection in mice induced strong immune responses and protected host from subsequent lethal wild-type WNV infection. Here, we investigated NS4B-P38G mutant infection in myeloid differentiation factor 88-deficient (MyD88(-/-...

journal_title：Vaccine

authors： Xie G,Welte T,Wang J,Whiteman MC,Wicker JA,Saxena V,Cong Y,Barrett AD,Wang T

更新日期：2013-08-28 00:00:00

abstract：:Since 1992, hepatitis B vaccine has been an integrated part of Thailand's expanded programme on immunisation (EPI). Based on the data from five representative provinces, we have evaluated its impact on the countrywide prevalence of HBV infection and carrier rate. The population studied comprised 400-488 healthy and im...

journal_title：Vaccine

authors： Poovorawan Y,Theamboonlers A,Vimolket T,Sinlaparatsamee S,Chaiear K,Siraprapasiri T,Khwanjaipanich S,Owatanapanich S,Hirsch P,Chunsuttiwat S

更新日期：2000-11-22 00:00:00

abstract：:An effective vaccination strategy against human immunodeficiency virus type 1 (HIV-1) should include the induction of potent cellular immune responses against conserved HIV-1 antigens. We have generated five replication competent recombinant influenza viruses (rFlu/SIV Gag nos. 1-5) expressing different portions of Ga...

journal_title：Vaccine

authors： Nakaya Y,Zheng H,García-Sastre A

更新日期：2003-05-16 00:00:00

abstract：:Current infant vaccination against pertussis in North America and Australia requires three doses of vaccines including diphtheria, tetanus and acellular pertussis antigens (DTaP) at 2, 4 and 6 months of age. Interest is growing in the possibility that vaccination at birth might provide earlier protection of infants, b...

journal_title：Vaccine

authors： White OJ,Rowe J,Richmond P,Marshall H,McIntyre P,Wood N,Holt PG

更新日期：2010-03-19 00:00:00

abstract：:Vaccines against group B meningococcal infection tested in several field trials have all been extracts of the outer membrane of the bacteria. We have developed a single component vaccine based on the class 1 outer membrane protein P1 produced in a heterologous host Bacillus subtilis, and describe here its immunizing p...

journal_title：Vaccine

authors： Idänpään-Heikkilä I,Wahlström E,Muttilainen S,Nurminen M,Käyhty H,Sarvas M,Mäkelä PH

更新日期：1996-06-01 00:00:00

abstract：:There is an urgent need for an effective vaccine against human disease caused by Burkholderia pseudomallei, and although a wide range of candidates have been tested in mice none provide high level protection. We considered this might reflect the inability of these vaccine candidates to protect against chronic disease....

journal_title：Vaccine

authors： Champion OL,Gourlay LJ,Scott AE,Lassaux P,Conejero L,Perletti L,Hemsley C,Prior J,Bancroft G,Bolognesi M,Titball RW

更新日期：2016-03-29 00:00:00

abstract：BACKGROUND:Vaccines are specific medicines characterized by two country-specific market access processes: (1) a recommendation by National Immunization Technical Advisory Group (NITAG), and (2) a funding policy decision. OBJECTIVES:The objective of this study was to compare and analyze NITAGs of 13 developed countries...

journal_title：Vaccine

authors： Ricciardi GW,Toumi M,Weil-Olivier C,Ruitenberg EJ,Dankó D,Duru G,Picazo J,Zöllner Y,Poland G,Drummond M

更新日期：2015-01-01 00:00:00

abstract：:Immunization by convergent combinatorial peptide libraries, or 'mixotopes' represents an interesting approach for inducing broadly cross-reactive immune response to hypervariable pathogens. The authors have immunized rabbits with a series of eight HIV-1 V3-loop derived constructs of increasing complexity, and analysed...

journal_title：Vaccine

authors： Gras-Masse H,Boutillon C,Diesis E,Deprez B,Tartar A

更新日期：1997-10-01 00:00:00

abstract：:The success of immunization programs in lowering the incidence of vaccine preventable diseases (VPDs) has led to increased public attention on potential health risks associated with vaccines. As a result, a scientifically rigorous response to investigating reported adverse events following immunization (AEFI) and effe...

journal_title：Vaccine

authors： Gidudu JF,Shaum A,Habersaat K,Wilhelm E,Woodring J,Mast E,Zuber P,Amarasinghe A,Nelson N,Kabore H,Abad N,Tohme RA

更新日期：2020-11-17 00:00:00

abstract：:Purified tetanus toxoid, a high-molecular-weight protein, was entrapped within poly(L-lactic acid) (PLA) and poly(D,L-lactic/glycolic acid) (PLGA) microspheres prepared by either a solvent extraction or a solvent evaporation method carried out in a multiple emulsion system (water-in-oil-in-water). The physical integri...

journal_title：Vaccine

authors： Alonso MJ,Gupta RK,Min C,Siber GR,Langer R

更新日期：1994-03-01 00:00:00

abstract：:Monoclonal antibody 3C9 was the starting material in the definition of the epitope that led to the synthesis of the first efficient peptide vaccine against a viral disease (canine parvovirus) in the natural host (dog). In this report, we have analysed the specificity of the antibody at the single amino acid level and ...

journal_title：Vaccine

authors： Langeveld JP,Martinez-Torrecuadrada J,Boshuizen RS,Meloen RH,Ignacio Casal J

更新日期：2001-03-21 00:00:00

abstract：:Trivalent avian influenza (AIV) antigens (H4N8, H5N2 and H7N3), mixed with positively charged, negatively charged and neutral avridine-containing liposomes, and oil-emulsion were subcutaneously administered to 6-week-old turkeys. Charged liposomal avridine adjuvant, either positive or negative, produced a better antib...

journal_title：Vaccine

authors： Fatunmbi OO,Newman JA,Sivanandan V,Halvorson DA

更新日期：1992-01-01 00:00:00

abstract：:Since its registration in 2002, Gudair® vaccine has become the key tool for managing paratuberculosis in sheep in Australia. This study was conducted to evaluate its effectiveness in reducing paratuberculosis prevalence in 12 flocks over more than one decade. Flocks with variable initial prevalence (5, 4 and 3 with lo...

journal_title：Vaccine

authors： Dhand NK,Eppleston J,Whittington RJ,Windsor PA

更新日期：2016-09-30 00:00:00

abstract：:Codon-pair bias de-optimization (CPBD) of viruses involves re-writing viral genes using statistically underrepresented codon pairs, without any changes to the amino acid sequence or codon usage. Previously, this technology has been used to attenuate the influenza A/Puerto Rico/8/34 (H1N1) virus. The de-optimized virus...

journal_title：Vaccine

authors： Broadbent AJ,Santos CP,Anafu A,Wimmer E,Mueller S,Subbarao K

更新日期：2016-01-20 00:00:00

abstract：:Following a landmark clinical trial, the vaccine against Haemophilus influenzae type b (Hib) was introduced in The Gambia in 1997. Whilst the immunogenicity of this vaccine is well established subsequent to the doses administered under the EPI schedule, little data exists assessing longevity of protection, using serol...

journal_title：Vaccine

authors： Idoko OT,Roberts E,Cox M,Jafali J,Njie-Jobe J,Mackenzie G,Ota MO,Kampmann B

更新日期：2014-08-06 00:00:00