Abstract：
:There is an urgent need for an effective vaccine against human disease caused by Burkholderia pseudomallei, and although a wide range of candidates have been tested in mice none provide high level protection. We considered this might reflect the inability of these vaccine candidates to protect against chronic disease. Using Q-RT PCR we have identified 6 genes which are expressed in bacteria colonising spleens and lungs of chronically infected mice. Three of the genes (BPSL1897, BPSL3369 and BPSL2287) have been expressed in Escherichia coli and the encoded proteins purified. We have also included BPSL2765, a protein known to induce immune responses associated with a reduced incidence of chronic/recurrent disease in humans. Immunisation of mice with a combination of these antigens resulted in the induction of antibody responses against all of the proteins. Compared with mice immunised with capsular polysaccharide or LolC protein, mice immunised with the combination of chronic stage antigens showed enhanced protection against experimental disease in mice.
journal_name
Vaccinejournal_title
Vaccineauthors
Champion OL,Gourlay LJ,Scott AE,Lassaux P,Conejero L,Perletti L,Hemsley C,Prior J,Bancroft G,Bolognesi M,Titball RWdoi
10.1016/j.vaccine.2016.02.038subject
Has Abstractpub_date
2016-03-29 00:00:00pages
1665-71issue
14eissn
0264-410Xissn
1873-2518pii
S0264-410X(16)00201-2journal_volume
34pub_type
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