Abstract：
:Reaseheath line C chicks produced IgA, IgG and IgM in their serum, tears, spleen and Harderian gland (HG) as a consequence of oculotopical vaccination with the Hitchner B1 strain of Newcastle disease virus. The IgM response was seen first, at 5 days after vaccination, and antiviral IgM levels in the tears and serum were negatively correlated to the level of virus in HG over days 4 to 10 postinfection. The frequency of virus-specific IgM-antibody forming cells in the HG of 10-day-old birds that had been vaccinated at 1 day old could reach 1/30th of the total lymphoid cells prepared from the HG. Young chicks made an irregular or low response to inactivated virus by the intravenous route whereas 40-day-old birds made a high serum response to both live and inactivated virus. This emphasizes how day-old chicks respond well to live virus vaccination and that their IgM response is likely to have a role in the clearance of virus.
journal_name
Vaccinejournal_title
Vaccineauthors
Russell PH,Ezeifeka GOdoi
10.1016/0264-410x(95)80012-3subject
Has Abstractpub_date
1995-01-01 00:00:00pages
61-6issue
1eissn
0264-410Xissn
1873-2518pii
0264-410X(95)80012-3journal_volume
13pub_type
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