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Recombinant West Nile virus envelope protein E and domain III expressed in insect larvae protects mice against West Nile disease.

Abstract：

:In this study, West Nile virus (WNV) envelope (rE) protein and its domain III (rDIII) were efficiently expressed in a cost-effective system based on insect larvae as non-fermentative living biofactories. Mice immunized with the partially purified rE or rDIII elicited high antibodies titers that neutralized viral infectivity in cell culture and in suckling mice. All vaccinated animals were fully protected when challenged with neurovirulent WNV NY99. Passive transfer of protective antibodies from immunized mothers to their offspring occurred both by transplacental and lactation routes. These results indicate that the insect-derived antigens tested may constitute potential vaccine candidates to be further evaluated.

journal_name

Vaccine

journal_title

Vaccine

authors

Alonso-Padilla J,de Oya NJ,Blázquez AB,Escribano-Romero E,Escribano JM,Saiz JC

doi

10.1016/j.vaccine.2010.12.081

subject

Has Abstract

pub_date

2011-02-17 00:00:00

pages

1830-5

issue

9

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(10)01854-2

journal_volume

29

pub_type

杂志文章

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