当前位置： SCI文献检索 > VACCINE期刊下所有文献 > Multiple CD4 and CD8 T-cell activation parameters predict vaccine efficacy in vivo mediated by individual DC-activating agonists.

Multiple CD4 and CD8 T-cell activation parameters predict vaccine efficacy in vivo mediated by individual DC-activating agonists.

Abstract：

:A systematic comparison of the immunostimulatory capacity of TLR 2, 3, 4, 5, 7 and 9 agonists and an agonistic CD40-specific antibody was performed in a single long peptide vaccination model. All adjuvants activated DC in vitro but not all induced a strong functional T-cell response in vivo. Optimal clonal CD8(+) T-cell expansion depended on the capacity of agonists to mature pro-inflammatory DC and the duration of their in vivo stimulatory effect. Strong agonists promoted the induction of both antigen-specific IFNgamma-producing CD4(+) T-helper cells and high numbers of IFNgamma producing CD8(+) effector T-cells that killed target cells in vivo. Importantly, the capacity of an agonist to function as an adjuvant depended on the vaccine strategy used. Collectively, the multi-parameter system presented here can be used as a general road map to develop therapeutic vaccines.

journal_name

Vaccine

journal_title

Vaccine

authors

Welters MJ,Bijker MS,van den Eeden SJ,Franken KL,Melief CJ,Offringa R,van der Burg SH

doi

10.1016/j.vaccine.2006.10.049

subject

Has Abstract

pub_date

2007-02-09 00:00:00

pages

1379-89

issue

8

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(06)01185-6

journal_volume

25

pub_type

杂志文章

相关文献

VACCINE文献大全