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Use of a current varicella vaccine as a live polyvalent vaccine vector.

Abstract：

:Varicella-zoster virus (VZV) is the causative agent of varicella and zoster. The varicella vaccine was developed to control VZV infection in children. The currently available Oka vaccine strain is the only live varicella vaccine approved by the World Health Organization. We previously cloned the complete genome of the Oka vaccine strain into a bacterial artificial chromosome vector and then successfully reconstituted the virus. We then used this system to generate a recombinant Oka vaccine virus expressing mumps virus gene(s). The new recombinant vaccine may be an effective polyvalent live vaccine that provides protection against both varicella and mumps viruses. In this review, we discussed about possibility of polyvalent live vaccine(s) using varicella vaccine based on our recent studies.

journal_name

Vaccine

journal_title

Vaccine

authors

Murakami K,Mori Y

doi

10.1016/j.vaccine.2014.11.001

subject

Has Abstract

pub_date

2016-01-04 00:00:00

pages

296-298

issue

2

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(14)01508-4

journal_volume

34

pub_type

杂志文章,评审

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