Abstract：
BACKGROUND:A key consideration for expanding recommendations for influenza vaccination is a robust assessment of immunogenicity and efficiency of transplacental antibody transfer after maternal vaccination. METHODS:We pooled data from two trials of maternal influenza vaccination to analyze vaccine immunogenicity with more power than either trial had alone. We compared hemagglutination-inhibition (HAI) titers and titer factor change for women and their infants between trial arms using t-tests; maternal and infant putative seroprotective titers (HAI ≥ 1:40) within each trial arm and maternal seroconversion between trial arms using exact tests; and transplacental antibody transfer between trial arms using t-tests. We used marginal linear models and generalized estimating equations to examine the impact of time between maternal vaccination and delivery on transplacental antibody transfer, infant titers, and infant seroprotection. RESULTS:For all vaccine components (A/H1N1, A/H3N2, and Type B), >80% of vaccinated women had seroprotective titers, >60% of them seroconverted, and >50% of their infants were born with seroprotective titers. These immunogenicity outcomes occurred more often in vaccine recipients and their infants than in controls. No difference in efficiency of transplacental antibody transfer was observed between vaccine recipients and controls. CONCLUSIONS:Our results provide robust support for further expansion of maternal influenza vaccination recommendations. CLINICAL TRIALS REGISTRATION:NCT01430689 and NCT01306669.
journal_name
Vaccinejournal_title
Vaccineauthors
Amin AB,Nunes MC,Tapia MD,Madhi SA,Cutland CL,Wairagkar N,Omer SB,for BMGF Supported Maternal Influenza Immunization Trials Investigators Group.doi
10.1016/j.vaccine.2020.07.020subject
Has Abstractpub_date
2020-09-22 00:00:00pages
6478-6483issue
41eissn
0264-410Xissn
1873-2518pii
S0264-410X(20)30933-6journal_volume
38pub_type
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