The role of IL-10 and IgG1 in the protection and granulomatous response in Schistosoma mansoni P24-immunized mice.

abstract：BACKGROUND:In France, midwives have recently been authorized to administer various vaccines to women (including pregnant women), newborns, and their family members. This is expected to enhance vaccine coverage. However, the French high level of vaccine hesitancy is also observed in some healthcare workers. We thus aime...

journal_title：Vaccine

authors： Massot E,Epaulard O

更新日期：2018-08-16 00:00:00

abstract：:The development of single-dose vaccines, mainly those administered during childhood, which would effectively protect against certain diseases, would be a very important advance towards better immunization coverage and protection against the respective pathogens. Biodegradable polymeric microspheres which are 'programm...

journal_title：Vaccine

authors： Aguado MT

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Little is known about inactivated influenza vaccine effectiveness (IVE) in preventing very severe disease, including influenza-associated intensive care unit (ICU) admissions. METHODS:The Southern Hemisphere Influenza and Vaccine Effectiveness Research and Surveillance (SHIVERS) project enrolled adults (age...

journal_title：Vaccine

authors： Thompson MG,Pierse N,Sue Huang Q,Prasad N,Duque J,Claire Newbern E,Baker MG,Turner N,McArthur C,SHIVERS investigation team.

更新日期：2018-09-18 00:00:00

abstract：:The toxicity of Clostridium difficile large clostridial toxin B (TcdB) can be reduced by many orders of magnitude by a combination of targeted point mutations. However, a TcdB mutant with five point mutations (referred to herein as mTcdB) still has residual toxicity that can be detected in cell-based assays and in-viv...

journal_title：Vaccine

authors： Wang B,Wang S,Rustandi RR,Wang F,Mensch CD,Hong L,Kristopeit A,Secore S,Dornadula G,Kanavage A,Heinrichs JH,Mach H,Blue JT,Thiriot DS

更新日期：2015-01-01 00:00:00

abstract：:Six adjuvant formulations were compared for their ability to potentiate the primary and memory antibody responses in mice to three companion animal vaccine immunogens--feline leukemia virus (FeLV), feline immunodeficiency virus (FIV), and a recombinantly-derived heartworm antigen. The combination of a novel bacterial ...

journal_title：Vaccine

authors： Usinger WR

更新日期：1997-12-01 00:00:00

abstract：:Bovine viral diarrhea virus (BVDV) represents a major cattle disease with multiple forms including fetal infections resulting in persistently infected (PI) cattle. The objectives of this study were to investigate the immune response to six vaccines, five modified live viral (MLV) and one killed vaccine containing BVDV...

journal_title：Vaccine

authors： Fulton RW,Cook BJ,Payton ME,Burge LJ,Step DL

更新日期：2020-05-19 00:00:00

abstract：BACKGROUND:Influenza vaccination among health-care workers is poor, and the effectiveness of hospital vaccination programs remains unclear. Little is known about the effectiveness of intensive evidence-based vaccination programs in nursing staff. We determined whether the recommended vaccination rate could be achieved ...

journal_title：Vaccine

authors： Norton SP,Scheifele DW,Bettinger JA,West RM

更新日期：2008-06-02 00:00:00

abstract：BACKGROUND:In England, coverage for childhood vaccines have decreased since 2012/13 in the context of an increasingly visible anti-vaccination discourse. We determined whether anti-vaccination sentiment is the likely cause of this decline in coverage. METHODS:Descriptive study triangulating a range of data sources (va...

journal_title：Vaccine

authors： Edelstein M,Müller M,Ladhani S,Yarwood J,Salathé M,Ramsay M

更新日期：2020-07-14 00:00:00

abstract：:A conjugate vaccine against meningococcus A and C was prepared using the non-toxic mutant of diphtheria toxin CRM 197 as a carrier protein. Capsular polysaccharides of Neisseria meningitidis group A and C were hydrolysed and the resulting oligosaccharides were then coupled to CRM 197 in order to obtain conjugates with...

journal_title：Vaccine

authors： Costantino P,Viti S,Podda A,Velmonte MA,Nencioni L,Rappuoli R

更新日期：1992-01-01 00:00:00

abstract：:Effort has been made to identify protective antigens in order to develop a recombinant vaccine against leptospirosis. Several attempts failed to conclusively demonstrate efficacy of vaccine candidates due to the lack of an appropriate model of lethal leptospirosis. The purposes of our study were: (i) to test the virul...

journal_title：Vaccine

authors： Silva EF,Santos CS,Athanazio DA,Seyffert N,Seixas FK,Cerqueira GM,Fagundes MQ,Brod CS,Reis MG,Dellagostin OA,Ko AI

更新日期：2008-07-23 00:00:00

abstract：BACKGROUND:Immunization programs currently measure coverage by assessing the proportion of children 12-24 months who have been immunized but this does not address the important question of when the scheduled vaccines were administered. Data capturing the timing of vaccination in first 6 months, when severe disease is m...

journal_title：Vaccine

authors： Hughes MM,Katz J,Englund JA,Khatry SK,Shrestha L,LeClerq SC,Steinhoff M,Tielsch JM

更新日期：2016-02-10 00:00:00

abstract：:Rhodococcus equi causes severe pneumonia in foals and has recently gained attention as a significant opportunistic pathogen in immunocompromised humans. However, no effective vaccine to prevent rhodococcosis is currently available. In this study, we have engineered the food-grade bacterium Lactococcus lactis to secret...

journal_title：Vaccine

authors： Cauchard S,Bermúdez-Humarán LG,Blugeon S,Laugier C,Langella P,Cauchard J

更新日期：2011-12-09 00:00:00

abstract：:A method was developed for cultivation of the strain Shigella flexneri 2a 77 with two attenuated markers. It ensures the preservation of the initial properties of the strain. The regimen for control of dissolved oxygen level was optimized. It was established that yeast extract is a necessary component of the nutritive...

journal_title：Vaccine

authors： Nenkov P,Bratoeva M,Vitanov T,Marinova S,Denchev V,Linde K

更新日期：1987-09-01 00:00:00

abstract：:The presence of foot-and-mouth disease (FMD) in a country is a major obstacle to the development of agriculture because of its adverse effects on livestock production and agricultural exports. The eradication of FMD in sub-saharan Africa by the implementation of slaughtering-out is impractical for various reasons, but...

journal_title：Vaccine

authors： Hunter P

更新日期：1998-01-01 00:00:00

abstract：:In Italy systematic mandatory tetanus immunization of children started in 1968. In a national sample of 241 young males born after 1968 the prevalence of non-immune subjects was 11.2% (5.5% in the North-Centre, 15.9% in the South-Islands; p < 0.02). Comparing these data with the corresponding figure obtained in a prev...

journal_title：Vaccine

authors： D'Amelio R,Stroffolini T,Wirz M,Biselli R,Matricardi PM,Gentili G,Collotti C,Pasquini P

更新日期：1993-01-01 00:00:00

abstract：INTRODUCTION:In recent years, vaccine preventable diseases such as measles and pertussis have been re-emerging in Western countries, maybe because of decreasing participation in childhood vaccination programs in some countries. There is clear evidence for vaccine efficacy and the risk of adverse effects is low. This ne...

journal_title：Vaccine

authors： Óskarsson Ý,Guðnason Þ,Jónsdóttir GA,Kristinsson KG,Briem H,Haraldsson Á

更新日期：2015-12-16 00:00:00

abstract：BACKGROUND:1-Dose varicella vaccination was recommended for children in Beijing before November 2012. To further control school-based outbreaks and decrease incidence, a 2-dose vaccination was implemented in 2013. We described the varicella epidemiology and assessed impact of the 2-dose vaccination in Haidian district,...

journal_title：Vaccine

authors： Fu J,Jiang C,Wang J,Zhao F,Ma T,Shi R,Zhao Y,Zhang X

更新日期：2017-04-25 00:00:00

abstract：:To evaluate long-term immunogenicity of a virosomal subunit inactivated influenza vaccine in children with asthma, a prospective study was conducted during 2005-2006 influenza season in six public pediatric clinics in Milan and surroundings, Northern Italy. A single dose (0.5 ml) of a virosomal subunit inactivated inf...

journal_title：Vaccine

authors： Zuccotti G,Amendola A,Viganò A,Pariani E,Zappa A,Pogliani L,Giacomet V,Savarino A,Podestà A,Rottoli A,Tanzi E,Zanetti A,Radaelli G

更新日期：2007-09-17 00:00:00

abstract：OBJECTIVES:To determine the proportion of children whose parents prefer them to receive live, attenuated influenza vaccine (LAIV) or inactivated influenza vaccine (IIV), examine reasons for preferences, and determine what percentage of vaccinated children receive other than the preferred type of vaccine and why. METHO...

journal_title：Vaccine

authors： Santibanez TA,Kahn KE,Bridges CB

更新日期：2018-11-19 00:00:00

abstract：BACKGROUND:To support vaccine decision-making we estimated from the societal perspective the potential health impact and costs averted through immunization with three vaccines - Haemophilus influenzae type b (Hib), pneumococcal conjugate vaccine (PCV) and rotavirus vaccine (RVV). METHODS:Based on variability in diseas...

journal_title：Vaccine

authors： Constenla D,Liu T

更新日期：2019-12-10 00:00:00

abstract：:In this article, we review three mechanisms that contribute to sustaining serum antibody levels: (i) long-lived plasma cells; (ii) persisting or cross-reactive antigen, and (iii) polyclonal activation of all memory B cells. We also present a quantitative analysis of the secondary immune response that reveals the relat...

journal_title：Vaccine

authors： Traggiai E,Puzone R,Lanzavecchia A

更新日期：2003-06-01 00:00:00

abstract：:In presence of low or high levels of rotavirus-specific maternal antibodies, the ability of newborn mice to respond to immunization with rotavirus RF 8*-2/6/7 VLPs, was evaluated. After parenteral vaccination, 100% of offspring born to low-antibody-titer dams developed rotavirus-specific IgG antibodies (n=7). In contr...

journal_title：Vaccine

authors： Johansson E,Istrate C,Charpilienne A,Cohen J,Hinkula J,Poncet D,Svensson L,Johansen K

更新日期：2008-02-06 00:00:00

abstract：:In this study, the impact of Th1-inducing cytokine gene co-delivery and antigen boosting on humoral and cellular responses induced by multiepitopic DNA immunization in mice have been investigated. Intramuscular injection of mixed DNA constructs encoding for HIV-1 Gag, Tat and Nef proteins, co-administered with the DNA...

journal_title：Vaccine

authors： Billaut-Mulot O,Idziorek T,Loyens M,Capron A,Bahr GM

更新日期：2001-04-06 00:00:00

abstract：:Streptococcus pneumoniae is an important pathogen worldwide. Accurate sampling of S. pneumoniae carriage is central to surveillance studies before and following conjugate vaccination programmes to combat pneumococcal disease. Any bias introduced during sampling will affect downstream recovery and typing. Many variable...

journal_title：Vaccine

authors： Gladstone RA,Jefferies JM,Faust SN,Clarke SC

更新日期：2012-11-06 00:00:00

abstract：:Thirty-two rhesus monkeys were used to evaluate the dose response of a recombinant HEV vaccine, and the efficacy of the vaccine based on the ORF2 protein of the Pakistani strain for pre- and post-exposure vaccination against intravenous challenge with homologous or heterologous virus was examined. Post-exposure vaccin...

journal_title：Vaccine

authors： Tsarev SA,Tsareva TS,Emerson SU,Govindarajan S,Shapiro M,Gerin JL,Purcell RH

更新日期：1997-12-01 00:00:00

abstract：BACKGROUND:A randomized trial demonstrated that a high-dose inactivated influenza vaccine (IIV-HD) was 24.2% more efficacious than a standard-dose vaccine (IIV-SD) against laboratory-confirmed influenza illness in adults ≥65 years. To evaluate the consistency of IIV-HD benefits, supplemental analyses explored efficacy ...

journal_title：Vaccine

authors： DiazGranados CA,Dunning AJ,Robertson CA,Talbot HK,Landolfi V,Greenberg DP

更新日期：2015-08-26 00:00:00

abstract：INTRODUCTION:S. aureus is a pathogen to which individuals are exposed shortly after birth, with immune responses to S. aureus increasing during childhood. There is marked heterogeneity between the anti- S. aureus immune responses of different humans, the basis of which is not fully understood. METHODS:To investigate d...

journal_title：Vaccine

authors： Flaxman A,Yamaguchi Y,van Diemen PM,Rollier C,Allen E,Elshina E,Wyllie DH

更新日期：2019-01-14 00:00:00

abstract：BACKGROUND:Immunization with pneumococcal vaccines is an important prophylactic strategy for children with asplenia or splenic dysfunction, who are at high risk of bacterial infections (including S. pneumoniae). This study aimed to assess immunogenicity and safety of pneumococcal non-typeable Haemophilus influenzae pro...

journal_title：Vaccine

authors： Szenborn L,Osipova IV,Czajka H,Kharit SM,Jackowska T,François N,Habib MA,Borys D

更新日期：2017-09-25 00:00:00

abstract：:We have recently demonstrated that the novel glycoalkaloid tomatine, derived from leaves of the wild tomato Lycopersicon pimpinellifolium, can act as a powerful adjuvant for the elicitation of antigen-specific CD8+ T cell responses. Here, we have extended our previous investigation with the model antigen ovalbumin to ...

journal_title：Vaccine

authors： Heal KG,Sheikh NA,Hollingdale MR,Morrow WJ,Taylor-Robinson AW

更新日期：2001-07-20 00:00:00

abstract：INTRODUCTION:Streptococcus pneumoniae is a capsulated bacterium that can cause severe infection in patients with thalassemia major, particularly those who have undergone splenectomy. The absence of the spleen as well as zinc deficiency in splenectomized patients with thalassemia major increases the possibility of devel...

journal_title：Vaccine

authors： Sari TT,Akib AAP,Gatot D,Roswita Harahap A,Bardosono S,Hadinegoro SRS

更新日期：2017-08-16 00:00:00