Amount of maternal rotavirus-specific antibodies influence the outcome of rotavirus vaccination of newborn mice with virus-like particles.

abstract：:Ebola virus (EBOV) is among the deadliest pathogens known to man causing infrequent outbreaks of hemorrhagic disease. In humans, the case fatality rates in the outbreaks can reach 90%. During the West African epidemic almost 30,000 people were infected and of these over 11,000 fatalities were reported. Currently, we a...

journal_title：Vaccine

authors： Lehrer AT,Wong TS,Lieberman MM,Johns L,Medina L,Feldmann F,Feldmann H,Marzi A

更新日期：2019-11-08 00:00:00

abstract：OBJECTIVE:Despite recommendations by professional organizations that all pregnant women receive inactivated influenza vaccine, safety concerns remain a barrier. Our objective was to assess the effect of trivalent influenza vaccines (IIV3) during pregnancy on parent report 6-month infant development. METHODS:We conduct...

journal_title：Vaccine

authors： Avalos LA,Ferber J,Zerbo O,Naleway AL,Bulkley J,Thompson M,Cragan J,Williams J,Odouli R,Kauffman TL,Ball S,Shifflett P,Li DK

更新日期：2020-02-28 00:00:00

abstract：:There is an ongoing need for new adjuvants to facilitate development of vaccines against HIV, tuberculosis, malaria and cancer, amongst many others. Unfortunately, the most potent adjuvants are often associated with toxicity and safety issues. Inulin, a plant-derived polysaccharide, has no immunological activity in it...

journal_title：Vaccine

authors： Petrovsky N,Cooper PD

更新日期：2015-11-04 00:00:00

abstract：:Pfs25, a Plasmodium falciparum surface protein expressed during zygote and ookinete stages in infected mosquitoes, is a lead transmission-blocking vaccine candidate against falciparum malaria. To enhance immunogenicity, recombinant Pfs25 was chemically conjugated to recombinant nontoxic Pseudomonas aeruginosa ExoProte...

journal_title：Vaccine

authors： Zhu D,Wu Y,McClellan H,Dai W,Rausch K,Jones D,Aebig J,Barnafo E,Butler B,Lambert L,Narum DL,Duffy PE

更新日期：2017-05-31 00:00:00

abstract：:With the emergence of raccoons (Procyon lotor) as the primary rabies reservoir in the United States of America, a recombinant vaccinia-rabies glycoprotein (V-RG) virus vaccine was developed that protected raccoons by the oral route from rabies infection. Despite extensive laboratory evaluation, vaccine safety concerns...

journal_title：Vaccine

authors： Hanlon CA,Niezgoda M,Shankar V,Niu HS,Koprowski H,Rupprecht CE

更新日期：1997-02-01 00:00:00

abstract：:The European Region has set itself the goal of eliminating measles by 2010. Incidence has increased in recent years. This study sought to investigate outbreaks in Spain in the period 2005-2007, in order to identify measles-vulnerable groups and compare Spain to other European countries which have also had measles outb...

journal_title：Vaccine

authors： Peña-Rey I,Martínez de Aragón V,Mosquera M,de Ory F,Echevarría JE,Measles Elimination Plan Working Group in Spain.

更新日期：2009-06-19 00:00:00

abstract：:In the past, Latin America was considered to be an area of high endemicity for hepatitis A virus (HAV) infection, with most people infected in early childhood. A seroepidemiological study was recently undertaken in six countries to determine whether this pattern has changed. The highest seroprevalence of antibodies to...

journal_title：Vaccine

authors： Tanaka J

更新日期：2000-02-18 00:00:00

abstract：:FHbp is a major serogroup B meningococcal vaccine antigen. Binding of complement Factor H (FH) to FHbp is specific for human and some non-human primate FH. In previous studies, FH binding to FHbp vaccines impaired protective anti-FHbp antibody responses. In this study we investigated anti-FHbp antibody responses to a ...

journal_title：Vaccine

authors： Giuntini S,Beernink PT,Granoff DM

更新日期：2015-12-16 00:00:00

abstract：:Sodium periodate (10 mM, 4 degrees C) inactivated murine cytomegalovirus (MCMV) very rapidly (loss of 2 to 3 log of viral infectivity per minute). Periodate-treated MCMV (PI-MCMV) was shown to be innocuous in mice, as determined by the inability of the virus to replicate. PI-MCMV induced a strong humoral immune respon...

journal_title：Vaccine

authors： Geoffroy F,Moachon N,Rodwell J,Quash GA

更新日期：1996-12-01 00:00:00

abstract：:On 1 February 2016, in the context of the ongoing Zika virus epidemic, the WHO declared that the recently reported clusters of microcephaly and other neurological disorders constituted a Public Health Emergency of International Concern (PHEIC). In response, WHO in collaboration with UNICEF and a working group of indep...

journal_title：Vaccine

authors： Vannice KS,Giersing BK,Kaslow DC,Griffiths E,Meyer H,Barrett A,Durbin AP,Wood D,Hombach J

更新日期：2019-11-28 00:00:00

abstract：:Travellers often present late for the third dose of hepatitis B vaccination and measuring anti-HBs serology is common practice to ensure that these individuals are protected. We assessed the adequacy of immune response in 86 healthy travellers who had their third dose of hepatitis B (HB) vaccine performed more than 1 ...

journal_title：Vaccine

authors： Jackson Y,Chappuis F,Mezger N,Kanappa K,Loutan L

更新日期：2007-04-30 00:00:00

abstract：:Pseudorabies Virus (PRV) is the causative agent of Pseudorabies (PR), also known as Aujeszky's Disease, one of the most important infectious diseases in swine, resulting in huge economic losses to the swine industry globally. The emergence of mutant PRV strains after 2011 resulted in a sharp decrease in the efficacy o...

journal_title：Vaccine

authors： Zhang T,Liu Y,Chen Y,Wang A,Feng H,Wei Q,Zhou E,Zhang G

更新日期：2020-09-03 00:00:00

abstract：:Intranasal (i.n.) immunization of BALB/c mice with chimeric murine rotavirus EDIM (epizootic diarrhea of infant mice) VP6 and attenuated E. coli heat-labile toxin (LT), LT(R192G), stimulated >99% protection against rotavirus shedding after EDIM challenge. Here, we evaluated other potential adjuvants with chimeric VP6 ...

journal_title：Vaccine

authors： Choi AH,McNeal MM,Flint JA,Basu M,Lycke NY,Clements JD,Bean JA,Davis HL,McCluskie MJ,VanCott JL,Ward RL

更新日期：2002-03-15 00:00:00

abstract：:The live bacterial vaccine Mycobacterium bovis BCG (BCG) is a vehicle worth noticing for various protective antigens. The gene encoding the B-cell epitope of the oligopeptide repeating in the circumsporozoite protein (C.S. protein) of the rodent malaria parasite, Plasmodium yoelii, was inserted into the plasmid vector...

journal_title：Vaccine

authors： Matsumoto S,Yanagi T,Ohara N,Wada N,Kanbara H,Yamada T

更新日期：1996-01-01 00:00:00

abstract：:In a study to develop novel vaccination strategies against tuberculosis, we encapsulated DNA encoding Ag85B, MPT-64 and MPT-83 antigens mixed with dimethyldioctyldecyl ammonium bromide (DDA) into biodegradable poly(dl-lactide-co-glycolide, PLGA) microspheres. Scanning electron microscopy (SEM) analysis demonstrated a ...

journal_title：Vaccine

authors： Cai H,Hu XD,Yu DH,Li SX,Tian X,Zhu YX

更新日期：2005-07-14 00:00:00

abstract：:The incidence of Lyme disease has continued to rise despite attempts to control its spread. Vaccination of zoonotic reservoirs of human pathogens has been successfully used to decrease the incidence of rabies in raccoons and foxes. We have previously reported on the efficacy of a vaccinia virus vectored vaccine to red...

journal_title：Vaccine

authors： Kern A,Zhou CW,Jia F,Xu Q,Hu LT

更新日期：2016-08-31 00:00:00

abstract：:In Balb/c mice, the sterile protective immunity induced by immunization with radiation-attenuated Plasmodium yoelii sporozoites is eliminated by in vivo depletion of CD8+ T lymphocytes, suggesting that cytotoxic T lymphocytes (CTL) against malaria antigens expressed on infected hepatocytes are required for mediating t...

journal_title：Vaccine

authors： Sedegah M,Chiang CH,Weiss WR,Mellouk S,Cochran MD,Houghten RA,Beaudoin RL,Smith D,Hoffman SL

更新日期：1992-01-01 00:00:00

abstract：:The amounts of pertussis toxin (PT), filamentous haemagglutinin (FHA), 69 kDa outer membrane protein (69 kDa OMP) and agglutinogens (AGG) 2 and 3 in extracts from the Danish whole-cell pertussis vaccine were studied in quantitative capture ELISA. With the exception of PT, the most effective extraction of these antigen...

journal_title：Vaccine

authors： Ibsen PH,Petersen JW,Heron I

更新日期：1993-01-01 00:00:00

abstract：OBJECTIVE:The Public Health Center Vaccine Survey (PHCVS) examines the knowledge, attitudes, and beliefs about seasonal influenza and H1N1 vaccinations in a largely low-income, urban, public health clinic population in Los Angeles County, USA. DESIGN:A cross-sectional survey of vulnerable individuals at risk for sever...

journal_title：Vaccine

authors： Redelings MD,Piron J,Smith LV,Chan A,Heinzerling J,Sanchez KM,Bedair D,Ponce M,Kuo T

更新日期：2012-01-05 00:00:00

abstract：:The need for developing a case definition and guidelines for a local reaction at or near the injection site, methods for the development of the case definition and guidelines as an adverse event following immunization as well as the rationale for selected decisions about the case definition for a local reaction at or ...

journal_title：Vaccine

authors： Gidudu J,Kohl KS,Halperin S,Hammer SJ,Heath PT,Hennig R,Hoet B,Rothstein E,Schuind A,Varricchio F,Walop W,Brighton Collaboration Local Reactions Working Group for a Local Reaction at or near Injection Site.

更新日期：2008-12-09 00:00:00

abstract：:Plasmodium falciparum Pfs25 antigen, expressed on the surface of zygotes and ookinetes, is one of the leading targets for the development of a malaria transmission-blocking vaccine (TBV). Our laboratory has been evaluating DNA plasmid based Pfs25 vaccine in mice and non-human primates. Previously, we established that ...

journal_title：Vaccine

authors： Kumar R,Nyakundi R,Kariuki T,Ozwara H,Nyamongo O,Mlambo G,Ellefsen B,Hannaman D,Kumar N

更新日期：2013-06-28 00:00:00

abstract：:Wildebeest-associated malignant catarrhal fever (WA-MCF), a fatal disease of cattle caused by alcelaphine herpesvirus 1 (AlHV-1), is one of the most important seasonal diseases of cattle in wildebeest endemic areas, with annual incidence reaching 10%. Here we report efficacy of over 80% for a vaccine based on the atte...

journal_title：Vaccine

authors： Cook E,Russell G,Grant D,Mutisya C,Omoto L,Dobson E,Lankester F,Nene V

更新日期：2019-09-20 00:00:00

abstract：:Pseudomonas aeruginosa antimicrobial resistance is a major therapeutic challenge. DNA vaccination is an attractive approach for antigen-specific immunotherapy against P. aeruginosa. We explored the feasibility of employing Herpes simplex virus type 1 tegument protein, VP22, as a molecular tool to enhance the immunogen...

journal_title：Vaccine

authors： Yu X,Wang Y,Xia Y,Zhang L,Yang Q,Lei J

更新日期：2016-08-17 00:00:00

abstract：:Multiple-antigen peptides (MAPs), containing B- and T-cell epitopes of the Plasmodium falciparum circumsporozoite (CS) protein, have been designed to overcome the limitations of first-generation peptide vaccines caused by low epitope density, carrier toxicity and the lack of parasite-derived T-cell epitopes. The immun...

journal_title：Vaccine

authors： de Oliveira GA,Clavijo P,Nussenzweig RS,Nardin EH

更新日期：1994-08-01 00:00:00

abstract：BACKGROUND:BCR/ABL and Wilms' tumor 1 (WT1) are an ideal tumor associated antigens which can be used to develop a potential chronic myeloid leukemia (CML) dentritic cell (DC) vaccine. Here, we constructed a novel polyepitope vaccine which used recombinant lentiviral vector carrying BCR/ABL and WT1 genes, and determined...

journal_title：Vaccine

authors： Dong W,Zhang J,Shao N,Tian T,Li L,Jian J,Zang S,Ma D,Ji C

更新日期：2014-06-12 00:00:00

abstract：:Nine pigs were given a single inoculum of 100 microg of the all-D retro peptide corresponding to the immunodominant GH loop encompassing residues 141-159 of capsid protein VP1 of foot-and-mouth disease virus serotype A, sub-type 12. The peptide was conjugated to activated keyhole limpet haemocyanin and oil-adjuvanted ...

journal_title：Vaccine

authors： Nargi F,Kramer E,Mezencio J,Zamparo J,Whetstone C,Van Regenmortel MH,Briand JP,Muller S,Brown F

更新日期：1999-07-16 00:00:00

abstract：:The RNA N-glycosidase ribosome inactivating proteins (RIPs) constitute a ubiquitous family of plant- and bacterium-derived toxins that includes the category B select agents ricin, abrin and shiga toxin. While these toxins are potent inducers of intestinal epithelial cell death and inflammation, very little is known ab...

journal_title：Vaccine

authors： Neal LM,McCarthy EA,Morris CR,Mantis NJ

更新日期：2011-01-17 00:00:00

abstract：:Vaccine induced responses are often weaker in those individuals most susceptible to infection, namely the very young and the elderly, highlighting the need for safe and effective vaccine adjuvants. Herein we evaluated different archaeosome formulations as an adjuvant to the H1N1 influenza hemagglutinin protein and com...

journal_title：Vaccine

authors： Stark FC,Akache B,Ponce A,Dudani R,Deschatelets L,Jia Y,Sauvageau J,Williams D,Jamshidi MP,Agbayani G,Wachholz K,Harrison BA,Li X,Krishnan L,Chen W,McCluskie MJ

更新日期：2019-11-08 00:00:00

abstract：PURPOSE:GEN-003 is a candidate therapeutic HSV-2 vaccine containing a fragment of infected cell protein 4 (ICP4.2), a deletion mutant of glycoprotein D2 (gD2ΔTMR), and Matrix-M2 adjuvant. In a dose-ranging phase 1/2a clinical trial, immunization with GEN-003 reduced viral shedding and the percentage of reported herpeti...

journal_title：Vaccine

authors： Flechtner JB,Long D,Larson S,Clemens V,Baccari A,Kien L,Chan J,Skoberne M,Brudner M,Hetherington S

更新日期：2016-10-17 00:00:00

abstract：BACKGROUND:Patients with chronic kidney disease (CKD) often fail to produce protective antibodies to hepatitis B virus (HBV) surface antigen after vaccination. Diabetes mellitus (DM) is the most common cause of CKD; however it is not clear whether it affects immunological response to HBV vaccine in these patients. AIM...

journal_title：Vaccine

authors： Alavian SM,Tabatabaei SV

更新日期：2010-05-14 00:00:00