Amount of maternal rotavirus-specific antibodies influence the outcome of rotavirus vaccination of newborn mice with virus-like particles.


:In presence of low or high levels of rotavirus-specific maternal antibodies, the ability of newborn mice to respond to immunization with rotavirus RF 8*-2/6/7 VLPs, was evaluated. After parenteral vaccination, 100% of offspring born to low-antibody-titer dams developed rotavirus-specific IgG antibodies (n=7). In contrast, only 25% of offsprings born to high-antibody-titer dams responded to parenteral immunization (n=12). When comparing parenteral versus oral immunization in offspring to low-antibody-titer dams only 45% responded after oral immunization (n=6). In conclusion, the response to parenteral immunization was not hampered by the presence of low levels of maternal antibodies induced by a natural infection while oral immunization was impaired. However, high levels of maternal antibodies impaired the response to parenteral immunization.






Johansson E,Istrate C,Charpilienne A,Cohen J,Hinkula J,Poncet D,Svensson L,Johansen K




Has Abstract


2008-02-06 00:00:00
















  • Stability of RNA virus attenuation approaches.

    abstract::The greatest risk from live-attenuated vaccines is reversion to virulence. Particular concerns arise for RNA viruses, which exhibit high mutation frequencies. We examined the stability of 3 attenuation strategies for the alphavirus, Venezuelan equine encephalitis virus (VEEV): a traditional, point mutation-dependent a...


    pub_type: 杂志文章


    authors: Kenney JL,Volk SM,Pandya J,Wang E,Liang X,Weaver SC

    更新日期:2011-03-09 00:00:00

  • A novel mouse model for immunogenic evaluation of human HBV vaccines.

    abstract::To prepare a human HBV vaccine, investigators need an animal model that can help them screen and prioritize vaccine candidates. In this study, HBV/HLA-A2.1 double transgenic mice (dTg), confirmed by analysis of genomic integration and by observation of long-term expression of HBV and HLA genes, were generated for the ...


    pub_type: 杂志文章


    authors: Guo Y,Ren D,He X,Wang F,Jiang L,Song S,He Y,Sun S

    更新日期:2009-09-18 00:00:00

  • The choice of analytical methodology can alter conclusions regarding herd effects of paediatric pneumococcal vaccination programmes.

    abstract:BACKGROUND:Estimation of the magnitude of the herd effect on invasive pneumococcal disease (IPD) is important when evaluating health benefits and cost-effectiveness of paediatric pneumococcal conjugate vaccine (PCV) programmes and may influence policy makers' decisions on PCV use. Several epidemiological, programmatic,...


    pub_type: 杂志文章


    authors: Pirçon JY,Talarico CA,Bollaerts K,Hausdorff WP,Clarke CJ

    更新日期:2018-11-12 00:00:00

  • A soluble hexameric form of CD40 ligand activates human dendritic cells and augments memory T cell response.

    abstract::A strategy to improve the immunogenicity of candidate vaccines is to trigger the innate immune system. Triggering of CD40 at the surface of dendritic cells (DC) is essential in the induction of an efficient immune response. Although CD40 agonist antibodies have been shown to be potent inducers of immune responses in e...


    pub_type: 杂志文章


    authors: Miconnet I,Pantaleo G

    更新日期:2008-07-29 00:00:00

  • Antibodies to Plasmodium vivax transmission-blocking vaccine candidate antigens Pvs25 and Pvs28 do not show synergism.

    abstract::Transmission-blocking vaccines against malaria parasites target molecules expressed by sexual stage parasites to elicit antibodies that prevent the infection of the mosquito vector. Pvs25 and Pvs28, expressed on the surface of ookinetes, are potential candidates for such a vaccine and induce antibodies that block the ...


    pub_type: 杂志文章


    authors: Hisaeda H,Collins WE,Saul A,Stowers AW

    更新日期:2001-12-12 00:00:00

  • Improved vaccination against Newcastle disease by an in ovo recombinant HVT-ND combined with an adjuvanted live vaccine at day-old.

    abstract::The continuous outbreaks of fatal Newcastle disease (ND) in commercial poultry flocks demonstrate that current vaccination strategies are not fully efficacious and should be improved by new generation of vaccines. In this context, maternally immune conventional layer chickens were vaccinated in ovo with a turkey herpe...


    pub_type: 杂志文章


    authors: Rauw F,Gardin Y,Palya V,Anbari S,Lemaire S,Boschmans M,van den Berg T,Lambrecht B

    更新日期:2010-01-08 00:00:00

  • Antigen dependent and independent mechanisms that sustain serum antibody levels.

    abstract::In this article, we review three mechanisms that contribute to sustaining serum antibody levels: (i) long-lived plasma cells; (ii) persisting or cross-reactive antigen, and (iii) polyclonal activation of all memory B cells. We also present a quantitative analysis of the secondary immune response that reveals the relat...


    pub_type: 杂志文章,评审


    authors: Traggiai E,Puzone R,Lanzavecchia A

    更新日期:2003-06-01 00:00:00

  • Immunosuppressive drugs impairs antibody response of the polysaccharide and conjugated pneumococcal vaccines in patients with Crohn's disease.

    abstract:BACKGROUND:Patients with Crohn's disease (CD) have a higher risk of infectious diseases including pneumococcal infections, and the risk increases with immunotherapy. The primary endpoint of this study was to investigate the specific antibody response to two pneumococcal vaccines in CD patients with and without immunosu...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Kantsø B,Halkjær SI,Thomsen OØ,Belard E,Gottschalck IB,Jørgensen CS,Krogfelt KA,Slotved HC,Ingels H,Petersen AM

    更新日期:2015-10-05 00:00:00

  • Simple differentiation method of mumps Hoshino vaccine strain from wild strains by reverse transcription loop-mediated isothermal amplification (RT-LAMP).

    abstract::Mumps virus is still circulating and annual mumps outbreaks occur with fluctuating magnitudes in Japan. Aseptic meningitis has been reported after vaccination and it would be of importance to determine whether this was related to the vaccination. The objective of this study was to develop a sensitive, specific and rap...


    pub_type: 杂志文章


    authors: Yoshida N,Fujino M,Ota Y,Notomi T,Nakayama T

    更新日期:2007-01-26 00:00:00

  • Immunogenic properties of chimeric protein from espA, eae and tir genes of Escherichia coli O157:H7.

    abstract::Enterohemorrhagic Escherichia coli (EHEC) comprise an important group of enteric pathogens causing hemorrhagic colitis and hemolytic uremic syndrome. These bacteria need EspA (E) as a conduct for Tir (T) delivery to the host cell and surface arrayed intimin (I) which docks the bacterium to the translocated Tir. This p...


    pub_type: 杂志文章


    authors: Amani J,Salmanian AH,Rafati S,Mousavi SL

    更新日期:2010-10-04 00:00:00

  • Impact of the 10-valent pneumococcal non-typeable Haemophilus influenzae Protein D conjugate vaccine (PHiD-CV) on bacterial nasopharyngeal carriage.

    abstract::Pneumococcal conjugate vaccines (PCV) may reduce nasopharyngeal carriage (NPC) of Streptococcus pneumoniae vaccine strains (VT), but serotype replacement with non-vaccine strains (NVT) has been reported. Bacterial NPC after PHiD-CV vaccination was assessed in the second year of life. Open descriptive study of NPC repo...


    pub_type: 杂志文章


    authors: Prymula R,Hanovcova I,Splino M,Kriz P,Motlova J,Lebedova V,Lommel P,Kaliskova E,Pascal T,Borys D,Schuerman L

    更新日期:2011-02-24 00:00:00

  • Tetanus, diphtheria and acellular pertussis (Tdap) vaccination among healthcare personnel-United States, 2011.

    abstract:BACKGROUND:Health-care personnel (HCP) are at risk for exposure to and possible transmission of vaccine-preventable diseases. Receiving recommended vaccines is an essential prevention practice for HCP to protect themselves and their patients. The tetanus, diphtheria and acellular pertussis vaccine (Tdap) was recommende...


    pub_type: 杂志文章


    authors: Lu PJ,Graitcer SB,O'Halloran A,Liang JL

    更新日期:2014-01-23 00:00:00

  • Reverse vaccinology, a genome-based approach to vaccine development.

    abstract::The conventional approach to vaccine development requires cultivation of the pathogenic microorganism and its dissection using biochemical, immunological, and microbiological methods in order to identify the components important for immunity. This method, while successful in many cases, failed to provide a solution fo...


    pub_type: 杂志文章


    authors: Rappuoli R

    更新日期:2001-03-21 00:00:00

  • Pediatric hospitalizations attributable to rotavirus gastroenteritis among Cambodian children: Seven years of active surveillance, 2010-2016.

    abstract:BACKGROUND:Each year, approximately 1,066 Cambodian children under five years old die of diarrhea, and 51% of these deaths are due to rotavirus gastroenteritis. Quantifying childhood hospitalizations caused by severe rotavirus infections is also important in demonstrating disease burden caused by this virus. The object...


    pub_type: 杂志文章


    authors: Angkeabos N,Rin E,Vichit O,Chea C,Tech N,Payne DC,Fox K,Heffelfinger JD,Grabovac V,Nyambat B,Diorditsa S,Samnang C,Hossain MS

    更新日期:2018-12-14 00:00:00

  • A novel DNA adjuvant, N3, enhances mucosal and systemic immune responses induced by HIV-1 DNA and peptide immunizations.

    abstract:AIMS:The study was designed to evaluate a novel cationic lipid DNA adjuvant (N3) and its function for HIV-1gp160/rev DNA plasmid delivered intranasally. The primary N3/HIV-DNA plasmid immunizations were boosted intranasally with a gp41 peptide in a anionic L3 adjuvant. This novel prime-boost strategy of mucosal immuniz...


    pub_type: 杂志文章


    authors: Hinkula J,Devito C,Zuber B,Benthin R,Ferreira D,Wahren B,Schröder U

    更新日期:2006-05-22 00:00:00

  • N-fragment of edema factor as a candidate antigen for immunization against anthrax.

    abstract::The nontoxic N-terminal fragment of Bacillus anthracis edema factor (EF) was evaluated as a candidate antigen in an anthrax vaccine using a replication-incompetent adenoviral vector. An E1/E3 deleted adenovirus (Ad/EFn) encoding the N-terminal region 1-254 amino acids of the edema factor (EFn) was constructed using th...


    pub_type: 杂志文章


    authors: Zeng M,Xu Q,Hesek ED,Pichichero ME

    更新日期:2006-01-30 00:00:00

  • Detecting AIDS restriction genes: from candidate genes to genome-wide association discovery.

    abstract::The screening of common genetic polymorphisms among candidate genes for AIDS pathology in HIV exposed cohort populations has led to the description of 20 AIDS restriction genes (ARGs), variants that affect susceptibility to HIV infection or to AIDS progression. The combination of high-throughput genotyping platforms a...


    pub_type: 杂志文章


    authors: Hutcheson HB,Lautenberger JA,Nelson GW,Pontius JU,Kessing BD,Winkler CA,Smith MW,Johnson R,Stephens R,Phair J,Goedert JJ,Donfield S,O'Brien SJ

    更新日期:2008-06-06 00:00:00

  • Characterization of Schistosoma mansoni 44.7/56.8 kDa egg antigens recognized by human monoclonal antibodies which induce protection against experimental infection and proliferation of peripheral blood mononuclear cells from schistosomiasis patients.

    abstract::We described here the characterization of Schistosoma mansoni egg antigens recognized by human monoclonal antibodies B10 (HmAb-B10) and D5 (HmAb-D5). SDS-PAGE and Western blot analysis revealed that these monoclonals recognized two antigens of M W 44.7/56.8 kDa, with pI of 7.0 and 7.8, respectively. The passive transf...


    pub_type: 杂志文章


    authors: Hirsch C,Almeida CA,Doughty BL,Goes AM

    更新日期:1997-06-01 00:00:00

  • Factors associated with uptake of vaccination against pandemic influenza: a systematic review.

    abstract:BACKGROUND:In June 2009 a global influenza pandemic was declared by the World Health Organisation. A vaccination programme against H1N1 influenza was introduced in many countries from September 2009, but there was low uptake in both the general population and health professionals in many, though not all, countries. PU...


    pub_type: 杂志文章,meta分析,评审


    authors: Bish A,Yardley L,Nicoll A,Michie S

    更新日期:2011-09-02 00:00:00

  • Binding of antibodies to human immunodeficiency virus type 1 (HIV-1)-infected lymphocytes elicited by vaccines and by natural infection.

    abstract::Binding of antibodies to oligomeric envelope glycoprotein of R5-tropic primary isolates of human immunodeficiency virus type 1 (HIV-1) was studied by flow cytometry using sera from HIV-1 vaccine recipients and clade B and C HIV-1-infected patients, and monoclonal and polyclonal antibodies to neutralizing epitopes of H...


    pub_type: 杂志文章


    authors: Gorse GJ,Patel GB,Arbuckle JA,Belshe RB

    更新日期:2004-01-02 00:00:00

  • Antibodies against cell surface antigens as very potent immunological adjuvants.

    abstract::We describe here two very potent adjuvant systems which are thought to work directly on antigen specific lymphocytes, thus by-passing the normal route for adjuvants, which is to activate antigen presenting cells (APCs) inducing release of inflammatory cytokines with resultant side effects of local and systemic reactog...


    pub_type: 杂志文章


    authors: Barr T,Carlring J,Hatzifoti C,Heath AW

    更新日期:2006-04-12 00:00:00

  • Detecting and preventing reversion to toxicity for a formaldehyde-treated C. difficile toxin B mutant.

    abstract::The toxicity of Clostridium difficile large clostridial toxin B (TcdB) can be reduced by many orders of magnitude by a combination of targeted point mutations. However, a TcdB mutant with five point mutations (referred to herein as mTcdB) still has residual toxicity that can be detected in cell-based assays and in-viv...


    pub_type: 杂志文章


    authors: Wang B,Wang S,Rustandi RR,Wang F,Mensch CD,Hong L,Kristopeit A,Secore S,Dornadula G,Kanavage A,Heinrichs JH,Mach H,Blue JT,Thiriot DS

    更新日期:2015-01-01 00:00:00

  • Immunogenicity and reactogenicity of co-administered tetanus-diphtheria-acellular pertussis (Tdap) and tetravalent meningococcal conjugate (MCV4) vaccines compared to their separate administration.

    abstract::In the United States, co-administration of tetanus toxoid, reduced diphtheria toxoid and acellular pertussis (Tdap) vaccine and tetravalent meningococcal conjugate vaccine (MCV4) is recommended in adolescents. In this clinical study, 1341 adolescents received Tdap (Boostrix® GlaxoSmithKline) and MCV4 (Menactra®, Sanof...


    pub_type: 杂志文章,随机对照试验


    authors: Weston WM,Friedland LR,Wu X,Howe B

    更新日期:2011-01-29 00:00:00

  • Antigen adsorbed surface modified poly-ɛ-caprolactone microspheres stimulates both adaptive and innate immune response in fish.

    abstract::Surface modified poly-ɛ-caprolactone microspheres as an antigen carrier was explored in a fish model. Outer membrane vesicles of Edwardsiella tarda adsorbed on to surface modified poly-ɛ-caprolactone microspheres with chitosan and alginate induces both innate and adaptive immune responses which persist up to 63 days o...


    pub_type: 杂志文章


    authors: Behera T,Swain P

    更新日期:2012-07-27 00:00:00

  • Risk stacking of pneumococcal vaccination indications increases mortality in unvaccinated adults with Streptococcus pneumoniae infections.

    abstract:BACKGROUND:Several chronic disease states have been identified as pneumococcal vaccination indications due to their ability to increase pneumococcal disease development and subsequent mortality. However, the risk of mortality according to the number of these disease states present is unknown. We sought to determine the...


    pub_type: 杂志文章


    authors: Morton JB,Morrill HJ,LaPlante KL,Caffrey AR

    更新日期:2017-03-23 00:00:00

  • Sub-optimal prevalence of mumps antibodies in a population based study of young adults in Israel after 20 years of two dose universal vaccination policy.

    abstract:BACKGROUND:A recent mumps outbreak in Israel despite an ongoing national program of a 2-dose universal childhood vaccination policy since 1988, raised questions regarding population immunity among young adults. OBJECTIVE:To assess the seroprevalence of mumps antibodies among young Israeli adults born after 1987 in ord...


    pub_type: 杂志文章


    authors: Levine H,Ankol OE,Rozhavski V,Davidovitch N,Aboudy Y,Zarka S,Balicer RD

    更新日期:2011-03-24 00:00:00

  • Using immunization delivery strategies to accelerate progress in Africa towards achieving the Millennium Development Goals.

    abstract::Integration of health services brings together common functions within and between organizations to solve common problems, developing a commitment to a shared vision and goals, and using common technologies and resources to achieve these goals. Integration has been the frustrated rally call of Primary Health Care for ...


    pub_type: 杂志文章,评审


    authors: Clements CJ,Nshimirimanda D,Gasasira A

    更新日期:2008-04-07 00:00:00

  • Pandemic influenza A H1N1 vaccine in recipients of solid organ transplants: immunogenicity and tolerability outcomes after vero cell derived, non-adjuvanted, whole-virion vaccination.

    abstract::During the 2009/10 pandemic of influenza A (H1N1), the American Society of Transplantation and other health organizations recommended that immunocompromised patients should be vaccinated as the key preventive measure. Since there are no data available for the immunogenicity of the unadjuvanted pandemic influenza vacci...


    pub_type: 杂志文章


    authors: Lagler H,Wenisch JM,Tobudic S,Gualdoni GA,Rödler S,Rasoul-Rockenschaub S,Jaksch P,Redlberger-Fritz M,Popow-Kraupp T,Burgmann H

    更新日期:2011-09-16 00:00:00

  • Invasive pneumococcal disease: Clinical outcomes and patient characteristics 2-6 years after introduction of 7-valent pneumococcal conjugate vaccine compared to the pre-vaccine period, the Netherlands.

    abstract:BACKGROUND:Implementation of 7-valent pneumococcal conjugate vaccine (PCV7) in the Dutch national immunization program for infants led to a shift from vaccine to non-vaccine serotypes in invasive pneumococcal disease (IPD) in all age groups. We studied the impact of the serotype shift on clinical syndromes and outcomes...


    pub_type: 杂志文章


    authors: Wagenvoort GH,Sanders EA,Vlaminckx BJ,Elberse KE,de Melker HE,van der Ende A,Knol MJ

    更新日期:2016-02-17 00:00:00

  • Influenza vaccination coverage in adults belonging to defined target groups, Germany, 2003/2004.

    abstract::In 2003, a nationwide cross-sectional study was conducted to assess the current influenza vaccination coverage of the adult population of Germany, especially in persons belonging to defined target groups. Of 666 surveyed persons, 190 (adjusted 24%) had received influenza vaccination and 419 participants belonged to at...


    pub_type: 杂志文章


    authors: Wiese-Posselt M,Leitmeyer K,Hamouda O,Bocter N,Zöllner I,Haas W,Ammon A

    更新日期:2006-03-24 00:00:00