Abstract：
:Sodium periodate (10 mM, 4 degrees C) inactivated murine cytomegalovirus (MCMV) very rapidly (loss of 2 to 3 log of viral infectivity per minute). Periodate-treated MCMV (PI-MCMV) was shown to be innocuous in mice, as determined by the inability of the virus to replicate. PI-MCMV induced a strong humoral immune response, with a high level of neutralizing antibodies. Mice immunized with PI-MCMV were protected against death and infection, when a lethal challenge with the virulent virus was administered 3 weeks after immunization and from death but not infection when virulent virus was administered at 3 months. Finally, no reactivation of potentially latent challenge virus (sublethal dose at 3 weeks) was observed in animals immunosuppressed at 6 months after immunization. Taken together, these results suggest that periodate could serve as an inactivating agent to prepare killed vaccines.
journal_name
Vaccinejournal_title
Vaccineauthors
Geoffroy F,Moachon N,Rodwell J,Quash GAdoi
10.1016/s0264-410x(96)00116-8subject
Has Abstractpub_date
1996-12-01 00:00:00pages
1686-94issue
17-18eissn
0264-410Xissn
1873-2518pii
S0264-410X(96)00116-8journal_volume
14pub_type
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