Abstract:
:To generate CD4+ T-helper cell lines, lymphocytes from HIV-seronegative subjects were primed in vitro with peptides derived from the V3 loop of HIV-1 gp120. Antigen-specific reactivity was inhibited by an anti-DR monoclonal antibody, indicating HLA-class II dependency, but peptides could be recognized in different HLA-class II contexts. Three sites on V3LAI and two on V3MN were identified as targets of the respective V3LAI- and V3MN-specific lines. Recognition of V3 peptides was isolate-specific. The lines did not react against whole gp160, which suggests that V3 may be differently presented when used as such rather than as part of the entire glycoprotein. Similar results were obtained in chimpanzees immunized in vivo against V3LAI.
journal_name
Vaccinejournal_title
Vaccineauthors
Billaud JN,Yagello M,Gluckman JCdoi
10.1016/0264-410x(94)90010-8subject
Has Abstractpub_date
1994-01-01 00:00:00pages
46-55issue
1eissn
0264-410Xissn
1873-2518pii
0264-410X(94)90010-8journal_volume
12pub_type
杂志文章相关文献
VACCINE文献大全abstract::General vaccination with the 7-valent pneumococcal conjugate vaccine was recommended in Germany in July 2006 for all children <2 years. The proportion of reported invasive pneumococcal disease (IPD) caused by vaccine serotypes before vaccine introduction was considerably lower than in the US. We report data from natio...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2009.04.057
更新日期:2009-06-24 00:00:00
abstract::Malaria represents a major global health problem but despite extensive efforts, no effective vaccine is available. Various vaccine candidates have been developed that provide protection in animal models, such as a gene gun-delivered DNA vaccine encoding the circumsporozoite protein (CSP) of Plasmodium berghei. A commo...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2009.06.059
更新日期:2009-09-18 00:00:00
abstract:OBJECTIVE:To examine current vaccine sentiment on social media by constructing and analyzing semantic networks of vaccine information from highly shared websites of Twitter users in the United States; and to assist public health communication of vaccines. BACKGROUND:Vaccine hesitancy continues to contribute to subopti...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2017.05.052
更新日期:2017-06-22 00:00:00
abstract::Vaccines are everywhere hugely successful but are also under attack. The reason for the latter is the perception by some people that vaccines are unsafe. However that may be, vaccine safety, life any other scientific subject, must be constantly studied. It was from this point of view that a meeting was organized at th...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2020.01.024
更新日期:2020-02-18 00:00:00
abstract:INTRODUCTION:New vaccine introductions have put strains on vaccine supply chains around the world. While increasing storage and transportation may be the most straightforward options, it is also important to consider what financial and operational benefits can be incurred. In 2012, suboptimal vaccine coverage and impen...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2014.04.090
更新日期:2014-07-07 00:00:00
abstract::We aimed to estimate the effectiveness of H1N1/09 containing influenza vaccines against hospitalization from influenza in Australia. We performed a test-negative case control study in patients hospitalized in 15 sentinel Australian hospitals between March and November 2010, comparing influenza vaccination (H1N1/09 mon...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2011.07.087
更新日期:2011-10-06 00:00:00
abstract::Class I molecules are conformationally sensitive to peptide binding, prolonging the complex's half-life on the surface of the cell. By making a series of H2-Kb anchor motif amino acid point substitutions in the ovalbumin 257-264 octamer, we were able to analyse subtle changes in peptide binding, Kb stabilization and i...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/0264-410x(95)93320-9
更新日期:1995-02-01 00:00:00
abstract::In the present study the homologous and heterologous type and subtype specific cellular immune response induced by a wild type inactivated whole virus H5N1 Influenza (A/Vietnam/1203/2004) vaccine was evaluated. Two immunizations with the Vero cell derived H5N1 influenza vaccine on Day 0 and Day 21 induced significant ...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2010.10.065
更新日期:2010-12-16 00:00:00
abstract::Buffalopox virus (BPXV), an Indian variant of vaccinia virus (VACV), is a zoonotic agent and affects buffaloes, cattle and humans. A27L is one of the conserved major immuno-dominant envelope proteins of orthopox viruses (OPVs) involved in viral entry/maturation and elicits neutralizing antibodies. In this study, the A...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2015.08.058
更新日期:2015-10-05 00:00:00
abstract::By the strategy "reverse vaccinology" a number of new antigens have been identified in Neisseria meningitidis, which are potential candidates for a highly needed broad-spectrum meningococcal vaccine. In the present study we examined the prevalence, sequence constancies and variations of the genes encoding three of the...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2005.11.006
更新日期:2006-03-15 00:00:00
abstract::Nasal mucosal barrier is a key impediment for the absorption of influenza whole inactivated virus (WIV) intranasal vaccine. Yet it is still unclear how WIV cross the epithelial cells (ECs) in nasal cavity. Here, in vitro, a coculture system was well established, consisting of surrogate nasal ECs (Calu-3) and dendritic...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2015.01.022
更新日期:2015-03-10 00:00:00
abstract::Five week old, commercially available large white pigs were vaccinated with either a single dose or two doses of a recombinant porcine adenovirus expressing the glycoprotein D gene from pseudorabies virus (PRV). Pigs were monitored for the development of serum neutralizing antibodies to PRV and challenged 3 weeks afte...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/s0264-410x(01)00084-6
更新日期:2001-06-14 00:00:00
abstract::Oral polio vaccine (OPV) and diphtheria-tetanus-pertussis (DTP) vaccines are given simultaneously in routine immunisation programmes in developing countries. It is therefore difficult to determine the separate effects of these vaccines on survival. We used the shortage of DTP vaccine in Bissau to examine the impact of...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2004.02.009
更新日期:2004-08-13 00:00:00
abstract::After introduction of the 7-valent pneumococcal conjugate vaccine (PCV7) in the infant national immunization program (NIP) in the Netherlands in 2006, Streptococcus pneumoniae strains of the non-vaccine serotype 19A emerged and became the dominant serotype in carriage in children and their parents. Similar patterns we...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2015.11.060
更新日期:2016-01-20 00:00:00
abstract:BACKGROUND:Challenges in reaching good vaccination coverage against measles emerged in several European Union/European Economic Area Member States (EU/EEA MS) leading to progressive accumulation of susceptible individuals and outbreaks. The Burden of Communicable Diseases in Europe (BCoDE) project developed a methodolo...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2014.01.094
更新日期:2014-04-01 00:00:00
abstract::The trivalent inactivated vaccine (TIV) is used to prevent seasonal influenza virus infection in humans, however, the immunogenicity of this vaccine may be influenced by the priming effect of previous influenza vaccinations or exposure to antigenically related influenza viruses. The current study examines the immunoge...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2008.04.073
更新日期:2008-07-04 00:00:00
abstract::We investigated whether pre-existing adenovirus-specific immunity influenced the development of immunity to a foreign antigen expressed by recombinant adenovirus. Active adenovirus-specific immunity was induced in cotton rats by i.n. administration of wild type human adenovirus type 5 (HAd5) two weeks before immunisat...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/s0264-410x(98)00279-5
更新日期:1999-02-26 00:00:00
abstract::The feasibility of a combined diphtheria-tetanus-acellular pertussis-hepatitis B (DTPa-HBV) vaccine was assessed and a comparison made of immunogenicity and reactogenicity to DTPa and HBV vaccines mixed in one syringe and to concomitant but separate injections as a primary vaccination course in three groups of infants...
journal_title:Vaccine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0264-410x(97)00089-3
更新日期:1997-10-01 00:00:00
abstract::Humoral responses against extra-cellular HIV-1 Tat may be beneficial as Tat has been implicated in the viral pathogenesis associated with HIV-1 disease progression. We determined the levels of anti-Tat IgG in sera of HIV-1 seropositive individuals from the Rural Clinical Cohort in Uganda using nine different Tat prote...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2007.09.070
更新日期:2007-12-05 00:00:00
abstract::The proteolytic enzyme bromelain has been traditionally used to cleave the hemagglutinin (HA) protein at the C-terminus of the HA2 region to release the HA proteins from influenza virions. The bromelain cleaved HA (BHA) has been routinely used as an antigen to generate antiserum that is essential for influenza vaccine...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2011.11.101
更新日期:2012-01-20 00:00:00
abstract::Recently, efforts have been made to fill a so-called "vaccine gap" between Japan and other countries; however, more work remains. Concerns about adverse events following immunization (AEFI) resulted in an historically passive approach to policy making in the National Immunization Program (NIP). For example, reports of...
journal_title:Vaccine
pub_type: 杂志文章,评审
doi:10.1016/j.vaccine.2020.09.028
更新日期:2020-10-27 00:00:00
abstract::The aim of this work was to evaluate the microencapsulation by spray-drying of inactivated Vibrio cholerae, using methacrylic copolymers Eudragit® L30D-55 and FS30D. The microparticles obtained presented a particle size around 3.0 μm. The preparation temperature affected the morphology and the antigenicity of micropar...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2011.05.098
更新日期:2011-08-05 00:00:00
abstract::Taking the results of a prospective cohort study by our group that evaluated the effectiveness of the inactivated subunit virosomal influenza vaccine (Inflexal V), Crucell-Berna) in the prevention of influenza-related diseases and the reduction of its negative economic consequences, the economic costs and benefits for...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2009.01.053
更新日期:2009-05-26 00:00:00
abstract:BACKGROUND:Rabies is a neglected zoonotic disease with a global burden of approximately 59,000 human deaths a year. Once clinical symptoms appear, rabies is almost invariably fatal; however, with timely and appropriate post-exposure prophylaxis (PEP) consisting of wound washing, vaccine, and in some cases rabies immuno...
journal_title:Vaccine
pub_type: 杂志文章,评审
doi:10.1016/j.vaccine.2019.04.024
更新日期:2019-10-03 00:00:00
abstract::A vaccine against the gonadotrophin-releasing hormone (GnRH) is being developed as an immunological method for treatment of prostatic hypertrophy, based on the observation that active immunization against GnRH leads to the production of anti-GnRH antibodies which results in the shrinkage of the prostate gland. We have...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/0264-410x(93)90077-b
更新日期:1993-01-01 00:00:00
abstract::Foetal Bovine Serum (FBS) and porcine trypsin are one of the essential raw materials used in the manufacturing of cell culture based viral vaccines. Being from animal origin, these raw materials can potentially contaminate the final product by known or unknown adventitious agents. The issue is more serious in case of ...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2018.06.008
更新日期:2018-07-05 00:00:00
abstract::While health-care providers have used incentives in an attempt to motivate patients to obtain vaccinations, their effect on vaccination rates has not been systematically evaluated on a large scale. In this study, we examined whether mobile applications may improve population vaccination rates through enhanced communic...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2019.11.053
更新日期:2020-04-16 00:00:00
abstract::In case of an influenza pandemic, the world will be in a situation where potential vaccine supply will fall short by several billion doses from global needs. The World Health Organization (WHO) convened in Geneva on May 2-3, 2006 a consultation of all stakeholders in influenza vaccines and immunization to identify pra...
journal_title:Vaccine
pub_type:
doi:10.1016/j.vaccine.2006.07.021
更新日期:2006-09-29 00:00:00
abstract::Intranasal inactivated influenza vaccines have the advantage over parenteral vaccines in that they are not associated with the pain of an injection. However, they would be most useful if they were available for all age groups, including high-risk groups, and also would provide cross-protection against variant virus st...
journal_title:Vaccine
pub_type: 杂志文章,评审
doi:10.1016/j.vaccine.2010.05.019
更新日期:2010-08-31 00:00:00
abstract::In this report, we describe a short peptide, containing a T helper- and a B-cell epitope, located in the Gag protein of the caprine arthritis encephalitis virus (CAEV). This T-cell epitope is capable of inducing a robust T-cell proliferative response in vaccinated goats with different genetic backgrounds and to provid...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2005.08.043
更新日期:2006-01-30 00:00:00