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Vaccine administration in children with chronic kidney disease.

Abstract：

:Pediatric patients with severe chronic kidney disease (CKD) on conservative treatment, on dialysis, and those with renal transplantation are at a higher risk for infectious diseases as the result of impaired immune responses against infectious agents. Infections in these patients can have drastic consequences for disease morbidity and mortality. Immunization is a crucial preventive strategy for disease management in this pediatric population. However, vaccination coverage among children with CKD remains low due to safety concerns and doubts about vaccine immunogenicity and efficacy. In this study, we reviewed why children with CKD are at higher risk of infections, the importance of vaccinations among these children, barriers to vaccinations, and recommend the best vaccination schedules. Overall, vaccines have acceptable immunogenicity, efficacy, and safety profiles in children with CKD. However, in some cases, the protective antibody levels induced by vaccines and the benefits and risks of booster vaccine doses must be individually managed. Furthermore, close contacts and household members of these children should complete age-appropriate vaccination schedules to increase the child's indirect protection.

journal_name

Vaccine

journal_title

Vaccine

authors

Esposito S,Mastrolia MV,Prada E,Pietrasanta C,Principi N

doi

10.1016/j.vaccine.2014.09.038

subject

Has Abstract

pub_date

2014-11-20 00:00:00

pages

6601-6

issue

49

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(14)01306-1

journal_volume

32

pub_type

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