当前位置： SCI文献检索 > VACCINE期刊下所有文献 > Confronting the degeneracy of convergent combinatorial immunogens, or 'mixotopes', with the specificity of recognition of the target sequences.

Confronting the degeneracy of convergent combinatorial immunogens, or 'mixotopes', with the specificity of recognition of the target sequences.

Abstract：

:Immunization by convergent combinatorial peptide libraries, or 'mixotopes' represents an interesting approach for inducing broadly cross-reactive immune response to hypervariable pathogens. The authors have immunized rabbits with a series of eight HIV-1 V3-loop derived constructs of increasing complexity, and analysed the reactivity of the corresponding antisera towards a set of V3-related peptides. Results were surprisingly homogeneous. Mixotopes containing as many as several billion closely related combinatorial sequences were immunogenic, and able to induce V3-specific antibodies. These results suggest that serological cross-reactivity depends on the sequential similarity of the antigen with the parent immunogen. Such 'mixotopes' could represent a useful approach to vaccination against hypervariable pathogens.

journal_name

Vaccine

journal_title

Vaccine

authors

Gras-Masse H,Boutillon C,Diesis E,Deprez B,Tartar A

doi

10.1016/s0264-410x(97)00079-0

subject

Has Abstract

pub_date

1997-10-01 00:00:00

pages

1568-78

issue

14

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(97)00079-0

journal_volume

15

pub_type

杂志文章

相关文献

VACCINE文献大全
  • Mucosal co-immunization of mice with recombinant lactococci secreting VapA antigen and leptin elicits a protective immune response against Rhodococcus equi infection.

    abstract：:Rhodococcus equi causes severe pneumonia in foals and has recently gained attention as a significant opportunistic pathogen in immunocompromised humans. However, no effective vaccine to prevent rhodococcosis is currently available. In this study, we have engineered the food-grade bacterium Lactococcus lactis to secret...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2011.10.026

    authors： Cauchard S,Bermúdez-Humarán LG,Blugeon S,Laugier C,Langella P,Cauchard J

    更新日期：2011-12-09 00:00:00

  • Human papillomavirus (HPV) vaccination and subsequent sexual behaviour: evidence from a large survey of Nordic women.

    abstract：OBJECTIVE:To assess whether recipients and non-recipients of the human papillomavirus (HPV) vaccine subsequently differ in terms of sexual risk taking behaviour. DESIGN:Cross-sectional survey. Sequential analyses constructed from self-reported age at vaccination, age at first intercourse and age at response. SETTING:...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2014.07.025

    authors： Hansen BT,Kjær SK,Arnheim-Dahlström L,Liaw KL,Jensen KE,Thomsen LT,Munk C,Nygård M

    更新日期：2014-09-03 00:00:00

  • Novel chimeric porcine circovirus (PCV) with the capsid gene of the emerging PCV2b subtype cloned in the genomic backbone of the non-pathogenic PCV1 is attenuated in vivo and induces protective and cross-protective immunity against PCV2b and PCV2a subtype

    abstract：:Porcine circovirus type-2b (PCV2b) is the primary global causative agent of porcine circovirus-associated disease (PCVAD). In this study, we first constructed a novel chimeric virus (PCV1-2b) with the PCV2b capsid gene cloned into the backbone of non-pathogenic PCV1. A pathogenicity study conducted in caesarean-derive...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2010.10.050

    authors： Beach NM,Ramamoorthy S,Opriessnig T,Wu SQ,Meng XJ

    更新日期：2010-12-16 00:00:00

  • Clinical types of HBsAg-positive hepatitis.

    abstract：:Hepatitis B is a parenterally and sexually transmitted disease of global importance. It associates with hepatitis D in a consistent proportion of cases. The disease most frequently runs a subclinical and anicteric course, with a significant number of cases that become chronic. Chronic hepatitis may progress to cirrhos...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/0264-410x(93)90219-n

    authors： Nisini R,Rizzetto M

    更新日期：1993-01-01 00:00:00

  • Peptide vaccination is superior to genetic vaccination using a recombineered bacteriophage λ subunit vaccine.

    abstract：:Genetic immunization holds promise as a vaccination method, but has so far proven ineffective in large primate and human trials. Herein, we examined the relative merits of genetic immunization and peptide immunization using bacteriophage λ. Bacteriophage λ has proven effective in immune challenge models using both imm...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2011.12.070

    authors： Thomas BS,Nishikawa S,Ito K,Chopra P,Sharma N,Evans DH,Tyrrell DL,Bathe OF,Rancourt DE

    更新日期：2012-02-01 00:00:00

  • Intussusception and Kawasaki disease after rotavirus vaccination in Taiwanese infants.

    abstract：BACKGROUND:Since 2006, two rotavirus vaccines have been licensed in Taiwan, either as a 2- (RV1) or 3-dose (RV5) schedule administered at ages 2, 4, and 6 months. This study assessed the risk of intussusception and Kawasaki disease (KD) associated with rotavirus vaccines among infants. METHODS:Cases of intussusception...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2020.07.038

    authors： Huang WT,Juan YC,Liu CH,Yang YY,Chan KA

    更新日期：2020-09-11 00:00:00

  • Systemic immunization with CCL27/CTACK modulates immune responses at mucosal sites in mice and macaques.

    abstract：:Plasmid DNA is a promising vaccine platform that has been shown to be safe and able to be administered repeatedly without vector interference. Enhancing the potency of DNA vaccination through co-delivery of molecular adjuvants is one strategy currently under investigation. Here we describe the use of the novel chemoki...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2009.10.095

    authors： Kraynyak KA,Kutzler MA,Cisper NJ,Khan AS,Draghia-Akli R,Sardesal NY,Lewis MG,Yan J,Weiner DB

    更新日期：2010-02-23 00:00:00

  • Vaccination against hepatitis A during outbreaks starting in schools: what can we learn from experiences in central Italy?

    abstract：:Two outbreaks of hepatitis A started almost simultaneously in a maternal school and in a day care centre located at opposite sides of Florence, Italy, at the end of 2002. Both of them originated from immigrant children, and in both cases, hepatitis A was initially not recognised due to aspecific symptoms. While vaccin...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2005.01.044

    authors： Bonanni P,Franzin A,Staderini C,Pitta M,Garofalo G,Cecconi R,Santini MG,Lai P,Innocenti B

    更新日期：2005-03-18 00:00:00

  • New vaccine introductions in Africa before and during the decade of vaccines - Are we making progress?

    abstract：:Vaccines are excellent investments with far-reaching rewards beyond individual and population health, but their introduction into national programs has been historically slow in Africa. We provide an overview of the introduction of new and underutilized vaccines in countries of the WHO African Region by 2017, using da...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2019.05.002

    authors： Sambala EZ,Wiyeh AB,Ngcobo N,Machingaidze S,Wiysonge CS

    更新日期：2019-05-31 00:00:00

  • Immunogenicity and safety of a novel recombinant protective antigen anthrax vaccine (GC1109), a randomized, single-blind, placebo controlled phase II clinical study.

    abstract：BACKGROUND:The demand on effective and safe anthrax vaccine is increasing as a part of the preparedness for possible bioterrorism in the future. We performed a randomized, single-blind, placebo controlled phase II clinical study to evaluate the immunogenicity and safety of a novel recombinant protective antigen (rPA) a...

    journal_title：Vaccine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.vaccine.2019.05.057

    authors： Kang CK,Kim NH,Kim CJ,Rhie GE,Jo SK,Ahn M,Kang J,Choe PG,Park WB,Kim NJ,Oh MD

    更新日期：2019-06-27 00:00:00

  • Implementation of good clinical practice guidelines in vaccine trials in developing countries.

    abstract：:The practicalities when applying the ICH GCPs (International Conference on Harmonization 1996 Good Clinical Practices [EU, MHLW, FDA. International Conference on Harmonization Guideline for Good Clinical Practice; 1997] in less developed countries (ldcs) are seldom discussed and we found no guidelines as how to "adapt...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2006.09.079

    authors： Acosta CJ,Galindo CM,Ochiai RL,Danovaro-Holliday MC,Laure-Page A,Thiem VD,Jin Y,Khan MI,Sahito SM,Hamza HB,Park JK,Lee H,Bock H,Elyazeed RA,Albert MJ,Ascaso C,Robles TQ,Ali M,Ngai P,Puri MK,Koo YM,Agtini MD,So

    更新日期：2007-04-12 00:00:00

  • Public opinion on childhood immunisations in Iceland.

    abstract：INTRODUCTION:In recent years, vaccine preventable diseases such as measles and pertussis have been re-emerging in Western countries, maybe because of decreasing participation in childhood vaccination programs in some countries. There is clear evidence for vaccine efficacy and the risk of adverse effects is low. This ne...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2015.10.125

    authors： Óskarsson Ý,Guðnason Þ,Jónsdóttir GA,Kristinsson KG,Briem H,Haraldsson Á

    更新日期：2015-12-16 00:00:00

  • Characterization of foot-and-mouth disease virus from outbreaks in Ecuador during 2009-2010 and cross-protection studies with the vaccine strain in use in the region.

    abstract：:During the years 2009 and 2010 relevant epidemic waves of foot-and-mouth disease (FMD) serotype O occurred in Ecuador, representing a great drawback for the last stages of the ongoing eradication program in South America. This study describes the molecular and antigenic characterizations of 29 isolates collected from ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2011.08.120

    authors： Maradei E,Perez Beascoechea C,Malirat V,Salgado G,Seki C,Pedemonte A,Bonastre P,D'Aloia R,La Torre JL,Mattion N,Rodríguez Toledo J,Bergmann IE

    更新日期：2011-10-26 00:00:00

  • Multiple CD4 and CD8 T-cell activation parameters predict vaccine efficacy in vivo mediated by individual DC-activating agonists.

    abstract：:A systematic comparison of the immunostimulatory capacity of TLR 2, 3, 4, 5, 7 and 9 agonists and an agonistic CD40-specific antibody was performed in a single long peptide vaccination model. All adjuvants activated DC in vitro but not all induced a strong functional T-cell response in vivo. Optimal clonal CD8(+) T-ce...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2006.10.049

    authors： Welters MJ,Bijker MS,van den Eeden SJ,Franken KL,Melief CJ,Offringa R,van der Burg SH

    更新日期：2007-02-09 00:00:00

  • Comparative immunogenicity in children of mammalian cell-derived recombinant hepatitis B vaccine and plasma-derived hepatitis B vaccine.

    abstract：:Three doses of hepatitis B vaccine were given at 2, 4 and 9 months of age to 220 Senegalese infants living in the Dakar area of Senegal. Half of the infants received 5 micrograms plasma-derived hepatitis B vaccine (Hevac B) and the remainder 20 micrograms mammalian cell-derived recombinant hepatitis B vaccine (GenHeva...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/0264-410x(92)90067-t

    authors： Coursaget P,Bringer L,Sarr G,Bourdil C,Fritzell B,Blondeau C,Yvonnet B,Chiron JP,Jeannée E,Guindo S

    更新日期：1992-01-01 00:00:00

  • Vaccination as a means of control of foot-and-mouth disease in sub-saharan Africa.

    abstract：:The presence of foot-and-mouth disease (FMD) in a country is a major obstacle to the development of agriculture because of its adverse effects on livestock production and agricultural exports. The eradication of FMD in sub-saharan Africa by the implementation of slaughtering-out is impractical for various reasons, but...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(97)00170-9

    authors： Hunter P

    更新日期：1998-01-01 00:00:00

  • IFN-gamma, IL-4, IL-10 and IL-12 gene expression in BCG-Leishmania vaccination of Trypanosoma cruzi-infected mice.

    abstract：:We have previously shown that vaccination of BALB/c mice with a combination of BCG plus killed Leishmania promastigotes, applied by the i.p. route 10 and 3 days before Trypanosoma cruzi inoculation, prolonged their survival and decreased their parasitaemia. In the present study we show that the BCG-Leishmania vaccine ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(99)00426-0

    authors： Araujo Z,Heremans H,Stordeur P,Wissing M,Goldman M,Castes M,Carlier Y

    更新日期：2000-03-06 00:00:00

  • Pools of lipidated HTL-CTL constructs prime for multiple HBV and HCV CTL epitope responses.

    abstract：:Various peptide-based approaches to simultaneous induction of multiple cytotoxic T lymphocyte (CTL) responses were evaluated as part of ongoing efforts to develop immunotherapeutic vaccines for use in humans. To this end, HLA (human histocompatibility leukocyte antigen)-A2-restricted epitopes from several specific vir...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(97)00264-8

    authors： Oseroff C,Sette A,Wentworth P,Celis E,Maewal A,Dahlberg C,Fikes J,Kubo RT,Chesnut RW,Grey HM,Alexander J

    更新日期：1998-05-01 00:00:00

  • Lethal toxicity and adjuvant activities of synthetic TDM and its related compounds in mice.

    abstract：:Trehalose-6,6'-dimycolate (TDM) and its monosaccharide-type analogues were synthesized, and their lethal and adjuvant activities were examined in mice. All the monosaccharide-type analogues with a glucose or N-acetylglucosamine moiety were devoid of lethal toxicity to mice; in particular, D-GlcNAcM(1-deoxy) and D-GlcN...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/0264-410x(89)90242-9

    authors： Sakurai T,Saiki I,Ishida H,Takeda K,Azuma I

    更新日期：1989-06-01 00:00:00

  • Vaccination against the 2009 pandemic influenza A (H1N1) among healthcare workers in the major teaching hospital of Sicily (Italy).

    abstract：:The aim of the study was to investigate factors involved in vaccination acceptance among healthcare workers (HCWs) and adverse reactions rates associated with pandemic influenza vaccination. The study was carried out in the major teaching hospital of Sicily from November 2009 to February 2010 on 2267 HCWs. A total of ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2010.12.041

    authors： Amodio E,Anastasi G,Marsala MG,Torregrossa MV,Romano N,Firenze A

    更新日期：2011-02-04 00:00:00

  • Pneumococcal vaccination in patients with systemic lupus erythematosus: A multicenter placebo-controlled randomized double-blind study.

    abstract：BACKGROUND:Invasive pneumococcal disease and respiratory tract infections are both frequent and severe in patients with systemic lupus erythematosus (SLE). This study aimed to compare the immunological efficacy and safety of pneumococcal vaccination with the 23-valent polysaccharide (PPS) vaccine alone to a sequential ...

    journal_title：Vaccine

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.vaccine.2017.07.094

    authors： Grabar S,Groh M,Bahuaud M,Le Guern V,Costedoat-Chalumeau N,Mathian A,Hanslik T,Guillevin L,Batteux F,Launay O,VACCILUP study group.

    更新日期：2017-09-05 00:00:00

  • Construction and cellular immune response induction of HA-based alphavirus replicon vaccines against human-avian influenza (H5N1).

    abstract：:Several approaches are being taken worldwide to develop vaccines against H5N1 viruses; most of them, however, pose both practical and immunological challenges. One potential strategy for improving the immunogenicity of vaccines involves the use of alphavirus replicons and VP22, a herpes simplex type 1 (HSV-1) protein....

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2009.05.014

    authors： Yang SG,Wo JE,Li MW,Mi FF,Yu CB,Lv GL,Cao HC,Lu HF,Wang BH,Zhu H,Li LJ

    更新日期：2009-12-09 00:00:00

  • Oral administration of myostatin-specific whole recombinant yeast Saccharomyces cerevisiae vaccine increases body weight and muscle composition in mice.

    abstract：:Myostatin negatively regulates skeletal muscle growth. It was found that active immunization with myostatin-specific vaccine blocked myostatin function in vivo, which resulted in increase of body weight and muscle composition in mice. However, traditional vaccine and its administration method are expensive and laborio...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2011.08.007

    authors： Zhang T,Yang H,Wang R,Xu K,Xin Y,Ren G,Zhou G,Zhang C,Wang L,Zhang Z

    更新日期：2011-10-26 00:00:00

  • Burden of hospitalizations attributable to rotavirus infection in children in Spain, period 1999-2000.

    abstract：:The aim of this study is to provide estimates on the incidence of rotavirus infection requiring hospitalization in children

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2003.11.037

    authors： Gil A,Carrasco P,Jiménez R,San-Martín M,Oyagüez I,González A

    更新日期：2004-06-02 00:00:00

  • Duration of rubella immunity induced by two-dose measles, mumps and rubella (MMR) vaccination. A 15-year follow-up in Finland.

    abstract：:A national two-dose vaccination program with a combined measles, mumps and rubella (MMR-II) vaccine was introduced in Finland, in 1982, immunizing children at the ages of 14-18 months and 6 years. Antibody levels were determined from serial samples from a group of originally 350 children during 15 years. The latest sa...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(00)00139-0

    authors： Davidkin I,Peltola H,Leinikki P,Valle M

    更新日期：2000-07-15 00:00:00

  • Is freezing in the vaccine cold chain an ongoing issue? A literature review.

    abstract：:Vaccine exposure to temperatures below recommended ranges in the cold chain may decrease vaccine potency of freeze-sensitive vaccines leading to a loss of vaccine investments and potentially places children at risk of contracting vaccine preventable illnesses. This literature review is an update to one previously publ...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2016.09.070

    authors： Hanson CM,George AM,Sawadogo A,Schreiber B

    更新日期：2017-04-19 00:00:00

  • Safety and immunogenicity of varying dosages of trivalent inactivated influenza vaccine administered by needle-free jet injectors.

    abstract：:To evaluate the perceived pain, other adverse events, and immunogenicity of influenza virus vaccine administered by needle-free jet injector (JI) compared with that of vaccine administered by needle and syringe (N&S), we randomly assigned 304 healthy young adults to receive one of three dosages (0.5, 0.3, or 0.2 ml) o...

    journal_title：Vaccine

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0264-410x(01)00225-0

    authors： Jackson LA,Austin G,Chen RT,Stout R,DeStefano F,Gorse GJ,Newman FK,Yu O,Weniger BG,Vaccine Safety Datalink Study Group.

    更新日期：2001-09-14 00:00:00

  • Recombinant flagellins with deletions in domains D1, D2, and D3: Characterization as novel immunoadjuvants.

    abstract：:Bacterial flagellin activates the innate immune system and ultimately the adaptive immune system through a Toll-like receptor 5 (TLR5)-dependent signaling mechanism. Given that TLR5 is widely distributed in epithelia, flagellin is currently being developed as a mucosal adjuvant. Flagellin FliC from Salmonella enterica...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2018.12.009

    authors： Biedma ME,Cayet D,Tabareau J,Rossi AH,Ivičak-Kocjan K,Moreno G,Errea A,Soulard D,Parisi G,Jerala R,Berguer P,Rumbo M,Sirard JC

    更新日期：2019-01-21 00:00:00

  • Immunization of eyed channel catfish, Ictalurus punctatus, eggs with monovalent Flavobacterium columnare vaccine and bivalent F. columnare and Edwardsiella ictaluri vaccine.

    abstract：:The efficacy of a modified live monovalent Flavobacterium columnare vaccine and bivalent F. columnare and Edwardsiella ictaluri vaccines were evaluated following immersion vaccination of eyed channel catfish (Ictalurus punctatus) eggs. The modified live F. columnare vaccine was grown in modified Shieh broth and admini...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2006.09.055

    authors： Shoemaker CA,Klesius PH,Evans JJ

    更新日期：2007-01-22 00:00:00

  • Case-based surveillance enhanced with measles virus detection/genotyping is essential to maintain measles elimination in Aichi Prefecture, Japan.

    abstract：BACKGROUND:Japan was verified as having achieved measles elimination by the Measles Regional Verification Commission in the Western Pacific Region in March 2015. Verification of measles elimination implies the absence of continuous endemic transmission. After the last epidemic in 2007 with an estimated 18,000 cases, Ja...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2015.08.070

    authors： Minagawa H,Yasui Y,Adachi H,Ito M,Hirose E,Nakamura N,Hata M,Kobayashi S,Yamashita T

    更新日期：2015-11-09 00:00:00