Abstract:
BACKGROUND:Since 2006, two rotavirus vaccines have been licensed in Taiwan, either as a 2- (RV1) or 3-dose (RV5) schedule administered at ages 2, 4, and 6 months. This study assessed the risk of intussusception and Kawasaki disease (KD) associated with rotavirus vaccines among infants. METHODS:Cases of intussusception and KD in infants aged less than 365 days were identified from the National Health Insurance databases, from 1 January 2007 through 31 December 2014, using the first-ever ICD-9-CM diagnosis codes. Histories of rotavirus vaccination were obtained from the National Immunization Information System. The modified self-controlled case series design included vaccinated cases, and compared incidence rate ratios (IRRs) between the risk period (postvaccination days 1-21 [intussusception] or days 1-28 [KD]) and control period (ages 0-364 days outside the -14 to +21 [intussusception] or +28 [KD] days of vaccination) by each type and dose of vaccine. Conditional Poisson regression models were adjusted for age using age-in-week (7-day) categorization. RESULTS:Overall 2064 intussusception cases and 2079 KD cases were diagnosed in 567,726 recipients (5313 [0.9%] received both RV5 and RV1). An increase in intussusception risk was observed in the 1-7 days (IRR 12.59, 95% confidence interval [CI] 8.07-19.66) and 8-21 days (IRR 1.78, 95% CI 1.00-3.16) post dose 1 of RV1, but not RV5. Risk of KD was higher during the third week post dose 2 of RV5 (IRR 2.33, 95% CI 1.35-4.00), and fourth week post dose 1 of RV1 (IRR 1.98, 95% CI 1.16-3.40). CONCLUSION:Our finding of an increased risk of intussusception associated with RV1 in the first week after dose 1 is consistent with results of previous postlicensure studies. Further research should verify a potentially delayed risk of KD after rotavirus vaccination.
journal_name
Vaccinejournal_title
Vaccineauthors
Huang WT,Juan YC,Liu CH,Yang YY,Chan KAdoi
10.1016/j.vaccine.2020.07.038subject
Has Abstractpub_date
2020-09-11 00:00:00pages
6299-6303issue
40eissn
0264-410Xissn
1873-2518pii
S0264-410X(20)30956-7journal_volume
38pub_type
杂志文章相关文献
VACCINE文献大全abstract::A novel triterpenoidal saponin, called pulcherrimasaponin (CP05), isolated from the leaves of Calliandra pulcherrima Benth. shows remarkable similarities to the previously described potent adjuvant, QS21 saponin (Quillaja saponaria Molina). On the basis of chemical and physicochemical evidence, its structure was estab...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2004.08.022
更新日期:2005-01-11 00:00:00
abstract::The co-administration of the tetravalent meningococcal conjugate vaccine, MenACWY-TT, with a licensed hepatitis A and B vaccine, HepA/B (Twinrix(®)), was compared to their separate administration in this open, randomised, controlled study. Healthy subjects 11-17 years of age (n=611) were randomised (3:1:1) to receive ...
journal_title:Vaccine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.vaccine.2011.11.051
更新日期:2012-01-17 00:00:00
abstract::In the past, Latin America was considered to be an area of high endemicity for hepatitis A virus (HAV) infection, with most people infected in early childhood. A seroepidemiological study was recently undertaken in six countries to determine whether this pattern has changed. The highest seroprevalence of antibodies to...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/s0264-410x(99)00466-1
更新日期:2000-02-18 00:00:00
abstract:OBJECTIVES:The aims of this study were to (a) assess knowledge of official vaccination recommendations and attitudes towards vaccinations among adults and (b) examine their association with vaccination uptake among adults. METHODS:This study was part of the HaBIDS study (Hygiene and Behaviour Infectious Diseases Surve...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2018.03.050
更新日期:2018-04-25 00:00:00
abstract::Sweden was the first country in the world to introduce a two-dose programme of vaccination against measles, mumps and rubella with a combined vaccine (MMR). It was commenced in 1982 and the vaccination was carried out at the ages of 18 months and 12 years. In 1992-93 the first age-group vaccinated at 18 months reached...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/s0264-410x(97)88332-6
更新日期:1998-01-01 00:00:00
abstract::Mucosal immunization with a killed whole-cell pneumococcal vaccine, given with enterotoxin-related adjuvants, has been shown to confer multi-serotype protection against colonization of the nasopharynx and middle ear in mice. However, because novel mucosal immunization strategies may be difficult to implement, here we ...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2010.09.031
更新日期:2010-11-03 00:00:00
abstract::The HIV epidemic in the south Indian state of Karnataka disproportionately burdens key populations of men who have sex with men and female sex workers. Despite having successfully reduced HIV incidence among certain key populations through the use of targeted intervention, India's HIV epidemic remains one of its great...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2014.12.009
更新日期:2015-01-29 00:00:00
abstract::Patterns of microRNA expression appear to delineate the process of spontaneous neoplastic development-transformation (SPNDT) occurring in the African green monkey kidney (AGMK) VERO cell line (Teferedegne et al., 2010). Analysis of microarray data identified 6 microRNAs whose high-level of expression peaked when the W...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2017.04.004
更新日期:2017-10-04 00:00:00
abstract::Foot and Mouth Disease (FMD) is an acute disease caused by Foot and Mouth Disease Virus (FMDV) which causes important economy losses, this is why it is necessary to obtain a vaccine that stimulates a rapid and long-lasting protective immune response. Cliptox is a mineral microparticle that in earlier studies has shown...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2010.06.098
更新日期:2010-08-31 00:00:00
abstract::Alternative DNA vaccine constructs such as fully synthetic linear expressing cassettes (LECs) offer the advantage of accelerated manufacturing techniques as well as the lack of both antibiotic resistance genes and bacterial contaminants. The speed of manufacture makes LEC technology a possible future vaccination strat...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2012.02.071
更新日期:2012-11-06 00:00:00
abstract:OBJECTIVE:The purpose of this study was to assess the awareness and knowledge regarding human papillomavirus (HPV), HPV related conditions and HPV vaccine among nursing students, and to identify their attitudes towards HPV vaccination. MATERIALS AND METHODS:The study was carried out at a tertiary Women's Health Care C...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2013.01.033
更新日期:2013-04-19 00:00:00
abstract::In July 1999, the Department of Health launched a campaign to immunise all children aged from 0-17 years with a new vaccine giving protection against meningococcal group C infection. Following the campaign, a survey of Immunisation Co-ordinators in England was conducted to identify strengths and weaknesses of the camp...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/s0264-410x(03)00160-9
更新日期:2003-06-20 00:00:00
abstract:BACKGROUND:Typhoid fever remains a major public health problem in low- and middle-income countries where children aged 2-14 years bear the greatest burden. Vi polysaccharide is poorly immunogenic in children <2 years of age, and protection in adults is modest. The limitations of Vi polysaccharide vaccines can be overco...
journal_title:Vaccine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.vaccine.2018.05.038
更新日期:2018-06-18 00:00:00
abstract::Neutralizing antibodies play an essential part in antiviral immunity and are instrumental in preventing or modulating viral diseases. Polyclonal antibody preparations are increasingly being replaced by highly potent monoclonal antibodies (mAbs). Cocktails of mAbs and bispecific constructs can be used to simultaneously...
journal_title:Vaccine
pub_type: 杂志文章,评审
doi:10.1016/j.vaccine.2013.01.025
更新日期:2013-03-15 00:00:00
abstract::The feasibility of a combined diphtheria-tetanus-acellular pertussis-hepatitis B (DTPa-HBV) vaccine was assessed and a comparison made of immunogenicity and reactogenicity to DTPa and HBV vaccines mixed in one syringe and to concomitant but separate injections as a primary vaccination course in three groups of infants...
journal_title:Vaccine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0264-410x(97)00089-3
更新日期:1997-10-01 00:00:00
abstract::In order to provide an estimation of the direct and indirect benefits of pneumococcal vaccination with three protein-conjugate pneumococcal vaccines (PCV) we described the epidemiology and mortality from invasive pneumococcal disease (IPD) in Denmark between 2000 and 2005. Approximately 1080 cases were registered annu...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2008.04.040
更新日期:2008-07-04 00:00:00
abstract:BACKGROUND:Vaccination against Haemophilus influenzae type b (Hib) is included in routine pediatric immunization schedule in the United States. Previous vaccine shortages have created the need for additional options for Hib vaccination. METHODS:This phase III, randomized, multi-centered study (NCT01000974) evaluated t...
journal_title:Vaccine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.vaccine.2017.05.018
更新日期:2017-06-16 00:00:00
abstract::It is well documented that adjuvants improve the immune response generated by traditional viral vaccines, but less is known about the effects of adjuvants on the immune response elicited by DNA vaccines. In this study, we have investigated the use of RN-205 (immunomodulator containing a membrane rich in lipopolysaccha...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/s0264-410x(02)00211-6
更新日期:2002-06-21 00:00:00
abstract::First year medical students at an allopathic medical school regional campus were asked to complete a 10-question survey at both the beginning and the conclusion of a required course on immunology, hematology and oncology. The survey was designed to solicit student attitudes about vaccination and the students' level of...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2019.10.094
更新日期:2020-01-22 00:00:00
abstract::Clinical and serum antibody responses following intramuscular injection of two formulations of Salmonella typhi Vi capsular polysaccharide (Vi) were assessed in a double-blind evaluation. Healthy adults were randomly assigned to receive a 25 micrograms dose of liquid (Vi-Liq; n = 182) or freeze-dried Vi vaccine (Vi-Ly...
journal_title:Vaccine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0264-410x(94)90194-5
更新日期:1994-01-01 00:00:00
abstract::A robust vaginal immune response is considered essential for an effective prophylactic vaccine that prevents transmission of HIV and other sexually acquired diseases. Considerable attention has recently focused on the potential of vaginally administered vaccines as a means to induce such local immunity. However, the p...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2012.02.004
更新日期:2012-04-05 00:00:00
abstract::Vaccination of infants, children and adolescents against the hepatitis B virus (HBV) is mandatory in Italy. It is crucial to assess whether vaccinated subjects have protective antibody level during adulthood when the risk of HBV infection increases due to lifestyle or occupational exposure. Two groups of students atte...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2013.01.046
更新日期:2013-03-25 00:00:00
abstract::This study investigates the safety, immunogenicity and efficacy of different pox-vector vaccines expressing the haemagglutinin of a highly pathogenic (HP) H5N1 avian influenza virus (AIV) (A/chicken/Indonesia/7/03) in pigs. Pigs were vaccinated twice, with a 4-week interval, with a fowlpox (TROVAC), a canarypox (ALVAC...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2009.02.006
更新日期:2009-04-06 00:00:00
abstract::Antibodies to the epitope EFRH, representing residues 3-6 within the beta-amyloid (Abeta) sequence, were previously shown to affect the solubility and disaggregation of Abeta fibrils in vitro. Here, we describe a novel method of immunization, using as antigen the EFRH peptide displayed on the surface of the filamentou...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/s0264-410x(02)00609-6
更新日期:2003-03-07 00:00:00
abstract::Influenza H3N2 viruses have recently drifted from A/Wisconsin/67/05-like to A/Brisbane/10/07-like viruses. The effect of key amino acid substitutions in the hemagglutinin (HA) protein on the replication, antigenicity and immunogenicity of cold-adapted, live attenuated vaccine strains was examined. A/Brisbane/10/07 egg...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2010.03.078
更新日期:2010-05-28 00:00:00
abstract:BACKGROUND:In January 2015, Tajikistan introduced the monovalent rotavirus vaccine into the national immunization program. Our objective was to estimate pre-vaccine burden of rotavirus-associated hospitalizations in children <5 years of age in Tajikistan. METHODS:During January 2013-December 2014, active surveillance ...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2017.08.031
更新日期:2018-12-14 00:00:00
abstract:BACKGROUND:Between 2007 and 2011 the Netherlands was faced with an unprecedented Q fever outbreak with more than 4000 people affected. Dairy goats were considered the main source of infection. In addition to taking veterinary measures, the Dutch government offered an unlicensed vaccine against the causative bacterium C...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2013.03.062
更新日期:2013-05-28 00:00:00
abstract::Spores of the genus Bacillus have been used for a long time as probiotics for oral bacteriotherapy both in humans and in animals. Spores are also employed in a veterinary vaccine against anthrax. Despite this long lasting and extensive use, the specific contribution of spores to the beneficial effects of probiotics an...
journal_title:Vaccine
pub_type: 杂志文章,评审
doi:10.1016/s0264-410x(03)00207-x
更新日期:2003-06-01 00:00:00
abstract::We show here that the immunogenicity of the Modified Vaccinia Ankara MVA vaccine strain can be improved by deletion of the A35 gene, without diminishing the ability of the virus to replicate. Deletion of the A35 gene resulted in increased virus-specific immunoglobulin production, class switching to IgG isotypes, and v...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2011.02.023
更新日期:2011-04-12 00:00:00
abstract::The data presented here demonstrate that Salmonella typhi is capable of expressing an acid tolerance response (ATR) and that effective induction of this response (in nutrient-rich medium) occurs at pH 5.0 in anaerobic conditions. The candidate live oral S. typhi vaccine strains made by precise genetic methods and whic...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/0264-410x(94)90031-0
更新日期:1994-08-01 00:00:00