Feasibility study of a combined diphtheria-tetanus-acellular pertussis-hepatitis B (DTPa-HBV) vaccine, and comparison of clinical reactions and immune responses with diphtheria-tetanus-acellular pertussis (DTPa) and hepatitis B vaccines applied as mixed o

abstract：:Pertussis vaccine development has mainly focused on Bordetella pertussis, and consequently these vaccines contain B. pertussis antigens only. However, the related species Bordetella parapertussis can also cause pertussis, although symptoms associated with the disease are generally considered to be milder. Recent field...

journal_title：Vaccine

authors： David S,van Furth R,Mooi FR

更新日期：2004-05-07 00:00:00

abstract：:This commentary is a response to a systematic review, recently published in Vaccine, which investigates the effectiveness of educational interventions in increasing uptake of the human papillomavirus vaccine. The systematic review by Fu et al. (2014) enhances the field's understanding of human papillomavirus vaccine i...

journal_title：Vaccine

authors： Shapiro GK,Joyal-Desmarais K,Perez S,Rosberger Z

更新日期：2014-11-12 00:00:00

abstract：:110 children who were given the complete course of the inactivated hepatitis A vaccine (Havrix) were followed up 10 years later. Age-matched healthy children who were not inoculated served as controls. One month after two primary injections, all children were positive for serum antibody. After 10 years, 99.09% of inoc...

journal_title：Vaccine

authors： Bian GL,Ma R,Dong HJ,Ni HX,Hu FJ,Chen YR,Chen JQ,Zhou SY,Lin YX,Xu GZ

更新日期：2010-07-05 00:00:00

abstract：:During their sixth annual meeting held in Manila (Philippines), the Asian Rabies Expert Bureau (AREB) reviewed the implementation of programs for rabies prevention, control, and elimination in Asia. AREB members strongly support a "one health" approach for controlling rabies, combining increased public awareness, comm...

journal_title：Vaccine

authors： Dodet B,Asian Rabies Expert Bureau (AREB).

更新日期：2010-04-26 00:00:00

abstract：:A safe and effective pan-filovirus vaccine is highly desirable since the filoviruses Ebola virus (EBOV) and Marburg virus (MARV) cause highly lethal disease typified by unimpeded viral replication and severe hemorrhagic fever. Previously, we showed that expression of the homologous glycoprotein (GP) and matrix protein...

journal_title：Vaccine

authors： Swenson DL,Warfield KL,Negley DL,Schmaljohn A,Aman MJ,Bavari S

更新日期：2005-04-27 00:00:00

abstract：:The ability of ALVAC- or fowlpox-based simian immunodeficiency virus (SIV) vaccines to boost SIV-specific CD4+ and CD8+ T-cell responses was tested in 10 vaccinia-experienced macaques infected with SIVmac251. The CD8+ T-cell response to the dominant Gag(181-189) CM9 was quantitated in seven Mamu-A*01-positive macaques...

journal_title：Vaccine

authors： Nacsa J,Radaelli A,Edghill-Smith Y,Venzon D,Tsai WP,Morghen Cde G,Panicali D,Tartaglia J,Franchini G

更新日期：2004-01-26 00:00:00

abstract：:This phase 1 clinical trial assessed the safety and immunogenicity of a native outer membrane vesicle (NOMV) vaccine prepared from a lpxL2(-) synX(-) mutant of strain 44/76 with opcA expression stabilized. Thirty-four volunteers were assigned to one of the three dose groups (25 mcg, 25 mcg with aluminum hydroxide adju...

journal_title：Vaccine

authors： Keiser PB,Gibbs BT,Coster TS,Moran EE,Stoddard MB,Labrie JE 3rd,Schmiel DH,Pinto V,Chen P,Zollinger WD

更新日期：2010-10-08 00:00:00

abstract：:Non-pathogenic lactic acid bacteria (LAB) are attractive as live carriers to deliver protective antigens to the mucosal immune system. Both persisting and non-persisting strains of lactic acid bacteria have been evaluated and seem to work equally well by the systemic and nasal routes of administration. However, it is ...

journal_title：Vaccine

authors： Grangette C,Müller-Alouf H,Geoffroy M,Goudercourt D,Turneer M,Mercenier A

更新日期：2002-09-10 00:00:00

abstract：BACKGROUND:Measles is a highly infectious respiratory disease which causes 122,000 deaths annually. Although measles vaccine is extremely safe and effective, vaccine coverage could be improved by a vaccine that is more easily administered and transported. We developed an inhalable dry powder measles vaccine (MVDP) and ...

journal_title：Vaccine

authors： MVDP author group.,Cape S,Chaudhari A,Vaidya V,Mulay R,Agarkhedkar S,Shermer C,Collins M,Anderson R,Agarkhedkar S,Kulkarni PS,Winston S,Sievers R,Dhere RM,Gunale B,Powell K,Rota PA,Papania M

更新日期：2014-11-28 00:00:00

abstract：BACKGROUND:Although guidelines for prophylactic human papillomavirus (HPV) vaccination recommend two doses for girls ages 9-14 years, several studies have demonstrated similar protection with one dose. Our objective was to evaluate the long-term health and economic impacts of routine one-dose HPV vaccination compared t...

journal_title：Vaccine

authors： Burger EA,Campos NG,Sy S,Regan C,Kim JJ

更新日期：2018-08-06 00:00:00

abstract：:The phrase "Process is the Product" is often applied to biologics, including multicomponent vaccines composed of complex components that evade complete characterization. Vaccine production processes must be defined and locked early in the development cycle to ensure consistent quality of the vaccine throughout scale-u...

journal_title：Vaccine

authors： Sunasara K,Cundy J,Srinivasan S,Evans B,Sun W,Cook S,Bortell E,Farley J,Griffin D,Bailey Piatchek M,Arch-Douglas K

更新日期：2018-05-24 00:00:00

abstract：:Assuming that the level of Bacille Calmette Guerin (BCG) coverage gives a measure of access to immunisation services, it is possible to derive what fraction of infants are not immunised against measles due to under-utilisation of existing services (rather than unavailability of services). According to the most recent ...

journal_title：Vaccine

authors： Edmunds WJ,Gay NJ,Henao Restrepo AM,Olivé JM,Bele O

更新日期：2001-10-12 00:00:00

abstract：:Live cold-adapted recombinant bivalent vaccine of influenza type A was studied in a controlled field trial in 1982-1983 among nearly 30,000 children 3-15 years old. The bivalent vaccine consisted of recombinants 47/25/1 (H1N1) and 47/7/2 (H3N2) of wild-type viruses A/Brazil/11/78 (H1N1) and A/Bangkok/1/79 (H3N2) with ...

journal_title：Vaccine

authors： Alexandrova GI,Budilovsky GN,Koval TA,Polezhaev FI,Garmashova LM,Ghendon YuZ,Romanova YR,Smorodintsev AA

更新日期：1986-06-01 00:00:00

abstract：:The recent resurgence of pertussis in England and Wales has been marked by infant deaths and rising cases in teens and adults. To understand which age cohorts are most responsible for these trends, we employed three separate statistical methods to analyze high-resolution pertussis reports from 1982 to 2012. The fine-g...

journal_title：Vaccine

authors： Bento AI,Riolo MA,Choi YH,King AA,Rohani P

更新日期：2018-02-21 00:00:00

abstract：:The purpose of this study was to investigate the utility of various in vitro and in vivo methods to assess the stability of experimental vaccines containing tetanus toxoid (TT) within PLGA microspheres. In vitro, the breakdown of the encapsulating polymers into their acid components led to changes in the structure of ...

journal_title：Vaccine

authors： Sasiak AB,Bolgiano B,Crane DT,Hockley DJ,Corbel MJ,Sesardic D

更新日期：2000-11-22 00:00:00

abstract：:Recombinant replication-defective human adenovirus type 5 (Ad5) vaccines containing capsid-coding regions from foot-and-mouth disease virus (FMDV) have been demonstrated to induce effective immune responses and provide homologous protective immunity against FMDV in cattle. However, basic mechanisms of Ad5-FMDV vaccine...

journal_title：Vaccine

authors： Montiel N,Smoliga G,Arzt J

更新日期：2012-02-21 00:00:00

abstract：:Despite a critical need for a respiratory syncytial virus (RSV) vaccine and decades of development efforts, a vaccine to protect infants, elderly, and other at-risk populations from RSV infection remains elusive. We have previously generated a new, live-attenuated vaccine candidate against RSV using rational, computer...

journal_title：Vaccine

authors： Mueller S,Stauft CB,Kalkeri R,Koidei F,Kushnir A,Tasker S,Coleman JR

更新日期：2020-03-23 00:00:00

abstract：:The feasibility of developing a prophylactic vaccine against SARS was assessed by comparing the immune responses elicited by immunizing mice with a recombinant SARS spike glycoprotein (S-protein) formulated with different adjuvants, given by different routes. In both young and aged mice, an intranasal Protollin-formul...

journal_title：Vaccine

authors： Hu MC,Jones T,Kenney RT,Barnard DL,Burt DS,Lowell GH

更新日期：2007-08-21 00:00:00

abstract：:In many industrialized countries, hepatitis A incidence rates have declined steadily in the past decades. Since future cohorts of non-vaccinated elderly will lack protection against disease and the burden of hepatitis A is higher with increasing age, this could be an argument in favour of taking preventive measures su...

journal_title：Vaccine

authors： Suijkerbuijk AW,Lugnér AK,van Pelt W,Wallinga J,Verhoef LP,de Melker HE,de Wit GA

更新日期：2012-07-27 00:00:00

abstract：:The need to enhance the immunogenicity of purified subunit antigens and modulate resulting immune responses has prompted the development of new adjuvants. Here, the ability of CpG oligodeoxynucleotides (ODN), a bovine host defence peptide indolicidin, and polyphosphazene to synergistically combine and enhance innate a...

journal_title：Vaccine

authors： Kovacs-Nolan J,Latimer L,Landi A,Jenssen H,Hancock RE,Babiuk LA,van Drunen Littel-van den Hurk S

更新日期：2009-03-23 00:00:00

abstract：:Measles, mumps and rubella (MMR) vaccination coverage in Italy has been decreasing starting from 2012 and, at the present, none of the Italian regions has achieved the goal of 95% coverage target. A decision of the Court of Justice of Rimini in March 2012 that awarded vaccine-injury compensation for a case of autism h...

journal_title：Vaccine

authors： Aquino F,Donzelli G,De Franco E,Privitera G,Lopalco PL,Carducci A

更新日期：2017-08-16 00:00:00

abstract：:Langmuir adsorption isotherms of endotoxin and aluminum-containing adjuvants at pH 7.4 and 25 degrees C revealed that aluminum hydroxide adjuvant has a greater adsorption capacity (283 microg/mg Al) and adsorption coefficient (1.3x10(4) ml/miccrog) than aluminum phosphate adjuvant (3.0 microg/mg Al, 0.20 ml/microg). T...

journal_title：Vaccine

authors： Shi Y,HogenEsch H,Regnier FE,Hem SL

更新日期：2001-02-08 00:00:00

abstract：OBJECTIVES:The objectives of this study were to estimate the national prevalence of hepatitis B infection in Tunisia using data from a nationwide survey, to compare results with those obtained in 1996 survey and to evaluate the impact of vaccination twenty years after its introduction. METHODS:A National household-bas...

journal_title：Vaccine

authors： Ben Hadj M,Bouguerra H,Saffar F,Chelly S,Hechaichi A,Talmoudi K,Bahrini A,Chouki T,Hazgui O,Hannachi N,Letaief H,Bellali H,Bahri O,Ben-Alaya-Bouafif N

更新日期：2018-09-18 00:00:00

abstract：OBJECTIVE:To determine if the addition of a physician peer educator would lead to improved immunization quality when compared to the traditional education provided as part of a vaccines for children (VFC) site visit. METHODS:A randomized controlled trial was conducted. Study participants were private pediatric and fam...

journal_title：Vaccine

authors： Taylor JA,Rietberg K,Greenfield L,Bibus D,Yasuda K,Marcuse EK,Duchin JS

更新日期：2008-08-05 00:00:00

abstract：:This study examines the potential clinical and economic benefits for adults arising from paediatric pneumococcal vaccination in the UK. A UK birth cohort model with a 10-year horizon and using a primary 4-dose paediatric 7-valent pneumococcal conjugate vaccine (PCV) schedule was populated with 1999 morbidity and morta...

journal_title：Vaccine

authors： McIntosh ED,Conway P,Willingham J,Hollingsworth R,Lloyd A

更新日期：2005-02-25 00:00:00

abstract：BACKGROUND:Use of a polysaccharide vaccine challenge to demonstrate immunologic memory after priming with capsular group C meningococcal conjugate vaccines (MenCC) risks induction of immunologic hyporesponsiveness. For this reason, MenCC vaccines are now used as probes of immunologic memory, however, no studies have de...

journal_title：Vaccine

authors： Pace D,Khatami A,Attard-Montalto S,Voysey M,Finn A,Faust SN,Heath PT,Borrow R,Snape MD,Pollard AJ

更新日期：2016-12-07 00:00:00

abstract：:Based on the reactivities of monoclonal antibodies, we previously reported that 25 Japanese encephalitis (JE) virus strains fell into five antigenic groups: Nakayama, Beijing-1, Kamiyama, 691004 and Muar. In the present study, we produced monoclonal antibodies against the Beijing-1 strain and obtained the Beijing-1 gr...

journal_title：Vaccine

authors： Satake Y,Hasegawa H,Yoshida M,Kobayashi Y

更新日期：1994-06-01 00:00:00

abstract：:Vaccination with viral-based vaccines continues to hold promise for the prevention of malaria. Whilst antigen-specific T cell responses are considered a major aim of such an approach, a role for induced NK cells as anti-malarial effector cells, or in shaping T cell responses, has received less attention. In this study...

journal_title：Vaccine

authors： Berthoud TK,Fletcher H,Porter D,Thompson F,Hill AV,Todryk SM

更新日期：2009-12-10 00:00:00

abstract：:To test the possibility of developing a combined vaccine against hepatitis A and E, groups of mice were immunized with different formulations containing different dosages of a commercially inactivated hepatitis A vaccine and a candidate recombinant hepatitis E vaccine. Monovalent vaccine components were used as contro...

journal_title：Vaccine

authors： Dong C,Dai X,Meng JH

更新日期：2007-02-19 00:00:00

abstract：:Herpes B virus (Cercopithecine herpesvirus 1) is endemic in captive macaque populations and poses a serious threat to humans who work with macaques or their tissues. A vaccine that could prevent or limit B virus infection in macaques would lessen occupational risk. To that end, a DNA vaccine plasmid expressing the B v...

journal_title：Vaccine

authors： Loomis-Huff JE,Eberle R,Lockridge KM,Rhodes G,Barry PA

更新日期：2001-09-14 00:00:00