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Immunogenicity of a DNA vaccine against herpes B virus in mice and rhesus macaques.

Abstract：

:Herpes B virus (Cercopithecine herpesvirus 1) is endemic in captive macaque populations and poses a serious threat to humans who work with macaques or their tissues. A vaccine that could prevent or limit B virus infection in macaques would lessen occupational risk. To that end, a DNA vaccine plasmid expressing the B virus glycoprotein B (gB) was constructed and tested for immunogenicity in mice and macaques. Intramuscular (IM) or intradermal (ID) immunization in mice elicited antibodies to gB that were relatively stable over time and predominately of the IgG2a isotype. Five juvenile macaques were immunized by either IM+ID (n=2) or IM (n=3) routes, with two booster immunizations at 10 and 30 weeks. All five animals developed antibodies to B virus gB, with detectable neutralizing activity in the IM+ID immunized animals. These results demonstrated that DNA immunization can be used to generate an immune response against a B virus glycoprotein in uninfected macaques.

journal_name

Vaccine

journal_title

Vaccine

authors

Loomis-Huff JE,Eberle R,Lockridge KM,Rhodes G,Barry PA

doi

10.1016/s0264-410x(01)00232-8

subject

Has Abstract

pub_date

2001-09-14 00:00:00

pages

4865-73

issue

32

eissn

0264-410X

issn

1873-2518

pii

S0264410X01002328

journal_volume

19

pub_type

杂志文章

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