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A novel DNA adjuvant, N3, enhances mucosal and systemic immune responses induced by HIV-1 DNA and peptide immunizations.

Abstract：

AIMS:The study was designed to evaluate a novel cationic lipid DNA adjuvant (N3) and its function for HIV-1gp160/rev DNA plasmid delivered intranasally. The primary N3/HIV-DNA plasmid immunizations were boosted intranasally with a gp41 peptide in a anionic L3 adjuvant. This novel prime-boost strategy of mucosal immunization provided a broad HIV-1 envelope specific immunity, and recognition of viruses of subtypes A, B and C. CONCLUSIONS:Intranasal N3-adjuvanted gp160/rev DNA prime followed by one L3-peptide boosting immunization, induced broadly neutralizing antibodies against HIV-1 in the mucosa and systemically. The needle-free intranasal prime-boost strategy using two different adjuvant formulations reduced significantly the dose of DNA needed.

journal_name

Vaccine

journal_title

Vaccine

authors

Hinkula J,Devito C,Zuber B,Benthin R,Ferreira D,Wahren B,Schröder U

doi

10.1016/j.vaccine.2005.08.015

subject

Has Abstract

pub_date

2006-05-22 00:00:00

pages

4494-7

issue

21

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(05)00810-8

journal_volume

24

pub_type

杂志文章

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