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Adaptive acid tolerance response by Salmonella typhi and candidate live oral typhoid vaccine strains.

Abstract：

:The data presented here demonstrate that Salmonella typhi is capable of expressing an acid tolerance response (ATR) and that effective induction of this response (in nutrient-rich medium) occurs at pH 5.0 in anaerobic conditions. The candidate live oral S. typhi vaccine strains made by precise genetic methods and which carry auxotrophic mutations were CVD 906 (carries defined attenuating deletion mutations: delta aroC, delta aroD), CVD 908 (carries defined attenuating deletion mutations: delta aroC, delta aroD), 541Ty (carries attenuating deletion mutations: aroA, purA), and galE, Vi-negative (via) strain EX462. All generate an effective ATR. In contrast, nitrosoguanidine-derived live oral typhoid vaccine strain Ty21a only weakly expresses acid tolerance. This further demonstrates that the non-specific mutagenesis process used to produce Ty21a affects genetic loci outside the intended target genes for mutagenesis, galE and via, and further emphasizes the importance of using precise genetic techniques when developing live oral S. typhi vaccines.

journal_name

Vaccine

journal_title

Vaccine

authors

Hone DM,Harris AM,Levine MM

doi

10.1016/0264-410x(94)90031-0

subject

Has Abstract

pub_date

1994-08-01 00:00:00

pages

895-8

issue

10

eissn

0264-410X

issn

1873-2518

pii

0264-410X(94)90031-0

journal_volume

12

pub_type

杂志文章

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