当前位置： SCI文献检索 > VACCINE期刊下所有文献 > Improvement of a recombinant avian avulavirus serotype 10 vectored vaccine by the addition of untranslated regions.

Improvement of a recombinant avian avulavirus serotype 10 vectored vaccine by the addition of untranslated regions.

Abstract：

BACKGROUND:We have previously developed a recombinant avian avulavirus serotype 10 (rAAvV-10/HA) expressing the hemagglutinin (HA) gene of a highly pathogenic avian influenza virus (HPAIV) as an emergency vaccine for poultry. rAAvV-10/HA can overcome the activity of the anti-AAvV-1 (Newcastle disease virus) antibody acquired by commercial chickens upon routine vaccination. Most chickens do not have the anti-AAvV-10 antibody, which could interfere with the vaccine efficacy. However, the vaccine efficacy of rAAvV-10/HA is not satisfactory in chickens even though it affords protection against an HPAIV challenge. In the present study, we improved the rAAvV-10/HA vaccine by enhancing the expression of the exogenous HA protein. METHODS:The 5' and 3' untranslated regions (UTR) of each AAvV-10 gene were flanked with the exogenous HA gene cassette to modify rAAvV-10/HA, yielding different rAAv10-UTRs. As a control, rAAv10-nonUTR that did not contain any UTRs was generated. The effects of UTRs on mRNA transcription, HA protein expression, and vaccine efficacy were then examined using embryonated chicken eggs and white leghorn chickens. RESULTS:The proportion of the HA gene mRNA among the vector-derived mRNAs (1.55-1.84-fold increase vs. the control) and HA protein levels (148-1151-fold increase vs. the control) in cells infected with rAAv10-UTRs were higher than in those infected with rAAv10-nonUTR. In vivo, vaccination of chickens with rAAv10-UTRs resulted in 100% protection against an HPAIV challenge. No chickens vaccinated with rAAv10-NP-UTR, rAAv10-F-UTR, or rAAv10-HN-UTR shed the virus in the throat and cloaca swabs. By contrast, rAAv10-nonUTR vaccination offered 70% protection, with 50% of chickens shedding the virus in the cloaca or throat swabs after the challenge. We conclude that the AAvV-10 UTRs can enhance the expression of the exogenous HA gene, resulting in improved efficacy of the rAAvV-10/HA vector vaccine. This improvement aids in the protection of flocks worldwide from the highly pathogenic avian influenza.

journal_name

Vaccine

journal_title

Vaccine

authors

Tsunekuni R,Tanikawa T,Nakaya T,Saito T

doi

10.1016/j.vaccine.2019.10.098

subject

Has Abstract

pub_date

2020-01-22 00:00:00

pages

822-829

issue

4

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(19)31500-2

journal_volume

38

pub_type

杂志文章

相关文献

VACCINE文献大全
  • Oxidized and reduced mannan mediated MUC1 DNA immunization induce effective anti-tumor responses.

    abstract：:DNA immunization is an attractive form of vaccination, which has shown promising results only in small animal models. There is a need to develop efficient gene delivery systems. We previously demonstrated that oxidized (OM) and reduced mannan (RM) complexed to ovalbumin DNA via poly-l-lysine (PLL), were able to genera...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2008.05.008

    authors： Tang CK,Sheng KC,Pouniotis D,Esparon S,Son HY,Kim CW,Pietersz GA,Apostolopoulos V

    更新日期：2008-07-23 00:00:00

  • Development of a fast-dissolving tablet formulation of a live attenuated enterotoxigenic E. coli vaccine candidate.

    abstract：:Vaccination is considered the most cost-effective approach to preventing infectious diseases, yet better formulations and delivery methods for efficient distribution and administration of vaccines are needed, especially for low-resource settings. A fast-dissolving tablet (FDT) that could be packaged in a compact stack...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2013.08.010

    authors： Lal M,Priddy S,Bourgeois L,Walker R,Pebley W,Brown J,Desai J,Darsley MJ,Kristensen D,Chen D

    更新日期：2013-10-01 00:00:00

  • Evaluation of the immunogenicity and protective efficacy of a candidate parainfluenza virus type 3 subunit vaccine in cotton rats.

    abstract：:A parainfluenza virus type 3 (PIV3) subunit vaccine consisting of detergent-solubilized, affinity-purified haemagglutinin-neuraminidase (HN) and fusion (F) surface glycoproteins was tested in cotton rats for immunogenicity, short-term effects on virus-induced immunopathology and protective efficacy. Groups of animals ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/0264-410x(91)90037-7

    authors： Ambrose MW,Wyde PR,Ewasyshyn M,Bonneau AM,Caplan B,Meyer HL,Klein M

    更新日期：1991-07-01 00:00:00

  • Hepatitis A vaccination coverage among adolescents (13-17 years) in the United States, 2008-2016.

    abstract：BACKGROUND:The hepatitis A (HepA) vaccine was recommended by the Advisory Committee on Immunization Practices (ACIP) incrementally from 1996 to 1999. In 2006, HepA vaccine was recommended (1) universally for children aged 12-23 months, (2) for persons who are at increased risk for infection, or (3) for any person wishi...

    journal_title：Vaccine

    pub_type： 历史文章,杂志文章

    doi：10.1016/j.vaccine.2018.01.090

    authors： Nelson NP,Yankey D,Singleton JA,Elam-Evans LD

    更新日期：2018-03-14 00:00:00

  • The expanded programme on immunization: a lasting legacy of smallpox eradication.

    abstract：:Since the mid-1970s, the widespread establishment and implementation of the Expanded Programme on Immunization (EPI) has led to remarkable achievements in controlling vaccine preventable diseases worldwide. Today, more children than ever are being reached with immunization; interruption of poliomyelitis transmission h...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2012.01.080

    authors： Okwo-Bele JM,Cherian T

    更新日期：2011-12-30 00:00:00

  • From transcriptome to immunome: identification of DTH inducing proteins from a Phlebotomus ariasi salivary gland cDNA library.

    abstract：:Delayed-type hypersensitivity (DTH) response to arthropod vector salivary proteins is associated with protection against pathogen transmission. Massive cDNA sequencing, high-throughput DNA plasmid construction and DNA immunisation were used to identify twelve DTH inducing proteins isolated from a Phlebotomus ariasi sa...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2005.07.085

    authors： Oliveira F,Kamhawi S,Seitz AE,Pham VM,Guigal PM,Fischer L,Ward J,Valenzuela JG

    更新日期：2006-01-16 00:00:00

  • Factors influencing the antibody response of dogs vaccinated against rabies.

    abstract：:Since 2000, there has been a legal requirement in the UK that dogs and cats should have an effective rabies vaccination with demonstrable sero-conversion if their owners wish to avoid quarantine on re-entry to the UK. In 2002, 10,483 rabies titres were determined on dogs at the VLA. Statistical analyses assessed the e...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2007.10.015

    authors： Kennedy LJ,Lunt M,Barnes A,McElhinney L,Fooks AR,Baxter DN,Ollier WE

    更新日期：2007-12-12 00:00:00

  • Expression of HIV-1 envelope gene by recombinant avipox viruses.

    abstract：:Recombinant canarypox (CP) and fowlpox (FP) viruses that contained two forms of the HIV-1 (SF2 strain) env gene were engineered and their expression analysed in chick, simian and human cells. These vectors can efficiently replicate in avian but not in mammalian cells, in which infection is abortive. The two forms, con...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/0264-410x(94)90180-5

    authors： Radaelli A,De Giuli Morghen C

    更新日期：1994-09-01 00:00:00

  • The Global Meningococcal Initiative: recommendations for reducing the global burden of meningococcal disease.

    abstract：:The Global Meningococcal Initiative (GMI) is composed of an international group of scientists, clinicians and public health officials with expertise in meningococcal immunology, epidemiology and prevention. The primary goal of the GMI is the promotion of the global prevention of invasive meningococcal disease through ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2011.02.058

    authors： Harrison LH,Pelton SI,Wilder-Smith A,Holst J,Safadi MA,Vazquez JA,Taha MK,LaForce FM,von Gottberg A,Borrow R,Plotkin SA

    更新日期：2011-04-18 00:00:00

  • SOCS1 downregulation in dendritic cells promotes memory T-cell responses.

    abstract：:SOCS1-1 is crucial for control of immune cell cytokine expression, including those cytokines known to enable memory T-cell formation and homeostasis. In this study, we found that immunization with SOCS1-downregulated bone marrow-derived dendritic cells generated increased antigen-specific CD8(+) T memory cells and ant...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2007.11.020

    authors： Aldrich M,Sanders D,Lapteva N,Huang XF,Chen SY

    更新日期：2008-02-20 00:00:00

  • Anti-tumor effect of DNA-based vaccination and dSLIM immunomodulatory molecules in mice with Ph+ acute lymphoblastic leukaemia.

    abstract：:Since the prognosis of patients with Philadelphia chromosome positive acute lymphoblastic leukaemia (Ph+ ALL) still remains poor, new relapse prevention strategies are needed. We evaluated the pre-immunization of mice with DNA-based vaccines subsequently challenged by the syngeneic Ph+ ALL cell line BM185. Ballistic t...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2008.06.094

    authors： Köchling J,Prada J,Bahrami M,Stripecke R,Seeger K,Henze G,Wittig B,Schmidt M

    更新日期：2008-08-26 00:00:00

  • Plasmodium falciparum polyoximes: highly immunogenic synthetic vaccines constructed by chemoselective ligation of repeat B-cell epitopes and a universal T-cell epitope of CS protein.

    abstract：:Effective immunoprophylaxis directed against the pre-erythrocytic stages of the malaria parasite requires a vaccine that can elicit humoral and cell mediated immunity in individuals of diverse genetic background. In order for a synthetic peptide malaria vaccine to meet these requirements, problems associated with gene...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(97)00238-7

    authors： Nardin EH,Calvo-Calle JM,Oliveira GA,Clavijo P,Nussenzweig R,Simon R,Zeng W,Rose K

    更新日期：1998-04-01 00:00:00

  • Safety of influenza vaccination during pregnancy: a review of subsequent maternal obstetric events and findings from two recent cohort studies.

    abstract：:Pregnant women and their infants are vulnerable to severe disease and secondary complications from influenza infection. For this reason, annual influenza vaccination is recommended for all pregnant women in the United States. Women frequently cite concerns about vaccine safety as a barrier to vaccination. This review ...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2014.04.021

    authors： Naleway AL,Irving SA,Henninger ML,Li DK,Shifflett P,Ball S,Williams JL,Cragan J,Gee J,Thompson MG,Vaccine Safety Datalink and Pregnancy and Influenza Project.

    更新日期：2014-05-30 00:00:00

  • Application of the Geographic Information System (GIS) in immunisation service delivery; its use in the 2017/2018 measles vaccination campaign in Nigeria.

    abstract：BACKGROUND:As global effort is made towards measles elimination, the use of innovative technology to enhance planning for the campaign has become critical. GIS technology has been applied to track polio vaccination activities in Nigeria with encouraging outcomes. Despite numerous measles vaccination campaigns after the...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2021.01.021

    authors： Oteri J,Idi Hussaini M,Bawa S,Ibizugbe S,Lambo K,Mogekwu F,Wiwa O,Seaman V,Kolbe-Booysen O,Braka F,Nsubuga P,Shuaib F

    更新日期：2021-01-18 00:00:00

  • Retro-inversion enhances the adjuvant and CpG co-adjuvant activity of host defence peptide Bac2A.

    abstract：:Host defence peptides (HDPs) have a variety of potential therapeutic applications, including as vaccine adjuvants, energizing efforts for modification strategies to address their toxicity and instability. Here we compare l, d and RI-Bac2A as vaccine adjuvants. d and RI-Bac2A are equally resistant to proteolytic degrad...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2010.02.015

    authors： Scruten E,Kovacs-Nolan J,Griebel PJ,Latimer L,Kindrachuk J,Potter A,Babiuk LA,Littel-van den Hurk Sv,Napper S

    更新日期：2010-04-09 00:00:00

  • The age-dependent risk of postvaccination complications in vaccinees with smallpox vaccine.

    abstract：:The use of vaccinia virus in recombinant systems may result in the occurrence of complications observed following smallpox vaccination. The results are presented of a large survey carried out in the USSR between 1968 and 1979. High complication rates are reported, particularly in older primary vaccinees; for example, ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/0264-410x(92)90023-d

    authors： Gurvich EB

    更新日期：1992-01-01 00:00:00

  • The immunopotentiator CVC1302 enhances immune efficacy and protective ability of foot-and-mouth disease virus vaccine in pigs.

    abstract：:The immunological enhancement characteristics of the immunopotentiator CVC1302 were evaluated for foot-and-mouth disease virus (FMDV) inactivated vaccine in pigs. Eight-week-old piglets were vaccinated with the foot-and-mouth disease (FMD) vaccine alone (FMD-vaccine group) or with the addition of CVC1302 (FMD-CVC1302 ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2018.11.012

    authors： Chen J,Yu X,Zheng Q,Hou L,Du L,Zhang Y,Qiao X,Hou J,Huang K

    更新日期：2018-12-18 00:00:00

  • Development of a simple, sensitive, rapid test which discriminates BCG-vaccinated from Mycobacterium bovis-infected cattle.

    abstract：:Bovine tuberculosis (bTB) is increasing in incidence in the UK. Effective control strategies could involve vaccination; BCG, either alone or in prime-boost strategies, remains the most effective vaccine against bovine tuberculosis. However, BCG vaccination of cattle would require development of diagnostic tests able t...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2008.07.059

    authors： Sopp P,Coad M,Hewinson G,Howard CJ,Cheallaigh CN,Keane J,Harris J,Hope JC

    更新日期：2008-10-09 00:00:00

  • A survey on human papillomavirus awareness and acceptance of vaccination among nursing students in a tertiary hospital in Ankara, Turkey.

    abstract：OBJECTIVE:The purpose of this study was to assess the awareness and knowledge regarding human papillomavirus (HPV), HPV related conditions and HPV vaccine among nursing students, and to identify their attitudes towards HPV vaccination. MATERIALS AND METHODS:The study was carried out at a tertiary Women's Health Care C...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2013.01.033

    authors： Uzunlar Ö,Özyer Ş,Başer E,Toğrul C,Karaca M,Güngör T

    更新日期：2013-04-19 00:00:00

  • Analysis of adenovirus-induced immunity to infection with Listeria monocytogenes: Fading protection coincides with declining CD8 T cell numbers and phenotypic changes.

    abstract：:Defining correlates of T cell mediated protection is important in order to accelerate the development of efficient T cell based vaccines conferring long-term immunity. Extensive studies have provided important insight regarding the characteristics and functional properties of the effector and memory CD8 T cells induce...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2018.03.080

    authors： Jahn ML,Steffensen MA,Christensen JP,Thomsen AR

    更新日期：2018-05-11 00:00:00

  • Country specific predictions of the cost-effectiveness of malaria vaccine RTS,S/AS01 in endemic Africa.

    abstract：BACKGROUND:RTS,S/AS01 is a safe and moderately efficacious vaccine considered for implementation in endemic Africa. Model predictions of impact and cost-effectiveness of this new intervention could aid in country adoption decisions. METHODS:The impact of RTS,S was assessed in 43 countries using an ensemble of models o...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2016.11.042

    authors： Galactionova K,Tediosi F,Camponovo F,Smith TA,Gething PW,Penny MA

    更新日期：2017-01-03 00:00:00

  • Two community hepatitis B outbreaks: an argument for vaccinating incarcerated persons.

    abstract：:Current recommendations have not resulted in routine vaccination of correctional facility inmates for hepatitis B. We investigated two hepatitis B outbreaks. Outbreak 1 involved 4 cases epidemiologically linked to persons who had been in jail. Outbreak 2 involved 48 community cases; 69% had a history of incarceration....

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2005.09.023

    authors： Devasia RA,Jones TF,Kainer MA,Halford S,Sheeler LL,Swift J,Schaffner W

    更新日期：2006-02-27 00:00:00

  • Evaluation of a single dose of half strength inactivated influenza vaccine in healthy adults.

    abstract：:Because of delays in the manufacturing of the 2000-2001, trivalent inactivated influenza vaccine in the US, there were concerns that there might be shortages of vaccine supply in the US. Therefore, we conducted a prospective, randomized, open-label, multicenter trial at six academic medical centers in the US, to evalu...

    journal_title：Vaccine

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0264-410x(01)00440-6

    authors： Treanor J,Keitel W,Belshe R,Campbell J,Schiff G,Zangwill K,Wolff M,Klimov A,Levandowski R,Lambert L

    更新日期：2002-01-15 00:00:00

  • Evaluation of immune response to recombinant potential protective antigens of Mycoplasma hyopneumoniae delivered as cocktail DNA and/or recombinant protein vaccines in mice.

    abstract：:Intramuscular immunization of mice with DNA cocktail vaccines, comprising potential protective antigens P36, P46, NrdF, and P97or P97R1 of Mycoplasma hyopneumoniae, induced strong Th1-polarized immune responses against each antigen, with only P46 eliciting a serum IgG response. Subcutaneous immunization with protein c...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2008.06.005

    authors： Chen AY,Fry SR,Daggard GE,Mukkur TK

    更新日期：2008-08-12 00:00:00

  • Multifaceted immune responses and protective efficacy elicited by a recombinant autolyzed Salmonella expressing FliC flagellar antigen of F18+Escherichia coli.

    abstract：:Porcine edema disease (ED) caused by F18+ Shiga toxin 2e-producing Escherichia coli (STEC) has imposed significant economic losses in the swine industry worldwide, resulting in sudden deaths in post-weaned piglets. The flagellin protein of F18+ STEC, a structural component of the flagellar filament, is a known virulen...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2016.10.066

    authors： Won G,Lee JH

    更新日期：2016-12-07 00:00:00

  • Persistence of antibody response to pneumococcal capsular polysaccharides in vaccinated long term-care residents in Brazil.

    abstract：:To evaluate the immunogenicity of 23-valent pneumococcal polysaccharide vaccine in 52 nursing homes residents aged > or = 60 years, IgG antibodies to serotypes 1, 5, 6B, and 8 were measured by ELISA and compared before, and 1 and 12 months following vaccination. A significant immunological response for all serotypes w...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2004.07.024

    authors： Brandão AP,de Oliveira TC,de Cunto Brandileone MC,Gonçalves JE,Yara TI,Simonsen V

    更新日期：2004-12-21 00:00:00

  • Single and booster dose responses to an inactivated hepatitis A virus vaccine: comparison with immune serum globulin prophylaxis.

    abstract：:Pre- and postexposure prophylaxis against hepatitis A virus (HAV) infection with immune serum globulin (Ig) is only effective for 4-6 months. We compared the safety, tolerability and immunogenicity of a single i.m. injection of Ig with a single and booster dose of an inactivated hepatitis A virus vaccine (iHAV) in adu...

    journal_title：Vaccine

    pub_type： 临床试验,杂志文章

    doi：10.1016/0264-410x(93)90151-m

    authors： Shouval D,Ashur Y,Adler R,Lewis JA,Armstrong ME,Davide JP,McGuire B,Kuter B,Brown L,Miller W

    更新日期：1993-01-01 00:00:00

  • Construction and evaluation of a double mutant of Shigella flexneri as a candidate for oral vaccination against shigellosis.

    abstract：:Based on studies on the genetic and molecular basis of Shigella flexneri invasive properties, we have constructed and evaluated a double mutant of S. flexneri serotype 5 for utilization as a live attenuated oral vaccine against shigellosis. The first mutation, icsA, blocks intracellular spread of bacteria as well as c...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/0264-410x(89)90160-6

    authors： Sansonetti PJ,Arondel J

    更新日期：1989-10-01 00:00:00

  • Estimating the public health importance of the CYD-tetravalent dengue vaccine: Vaccine preventable disease incidence and numbers needed to vaccinate.

    abstract：BACKGROUND:To evaluate the potential public health impact of the live attenuated tetravalent Sanofi Pasteur dengue vaccine (CYD-TDV) we analyzed data from the reported clinical trials to calculate vaccine preventable disease incidence (VPDI) and number needed to vaccinate (NNV) based on the licensure indication for per...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2016.03.017

    authors： Gessner BD,Wilder-Smith A

    更新日期：2016-04-29 00:00:00

  • Seroprevalence of anti-polio antibodies in a population 7 months to 39 years of age in Uruguay: Implications for future polio vaccination strategies.

    abstract：:This study evaluated the seroprevalence of poliovirus types 1, 2 and 3 antibodies and vaccination coverage in 780 subjects aged between 7 months and 39 years in Montevideo, Uruguay, where oral polio vaccine (OPV) is used. Antibody titers were measured and seroprotection rates and geometric mean titers (GMTs) were comp...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2009.02.042

    authors： Pírez MC,Olivera I,Diabarboure H,Montano A,Barañano R,Badía F,Bonnet MC

    更新日期：2009-05-05 00:00:00