Abstract：
:Bovine tuberculosis (bTB) is increasing in incidence in the UK. Effective control strategies could involve vaccination; BCG, either alone or in prime-boost strategies, remains the most effective vaccine against bovine tuberculosis. However, BCG vaccination of cattle would require development of diagnostic tests able to accurately discriminate Mycobacterium bovis-infected from BCG-vaccinated animals. Herein, we demonstrate that the detection of secreted IFN-gamma following short term culture (4h) of whole blood with purified protein derived from M. bovis (PPD-B) allows such discrimination. This reflects, in part, the differential kinetics of IFN-gamma secretion in infected compared to vaccinated cattle. This is the first study to demonstrate that accurate, rapid distinction of BCG-vaccinated from M. bovis-infected cattle can be achieved in a short time period without the need for production of M. bovis-specific antigens, complex antigen mixtures or extensive laboratory procedures. We were also able to detect PPD-specific IFN-gamma release during short term culture of blood from a number of humans with active TB indicating that this test may have wider application and is potentially useful for the rapid diagnosis of disease in humans.
journal_name
Vaccinejournal_title
Vaccineauthors
Sopp P,Coad M,Hewinson G,Howard CJ,Cheallaigh CN,Keane J,Harris J,Hope JCdoi
10.1016/j.vaccine.2008.07.059subject
Has Abstractpub_date
2008-10-09 00:00:00pages
5470-6issue
43eissn
0264-410Xissn
1873-2518pii
S0264-410X(08)01014-1journal_volume
26pub_type
杂志文章相关文献
VACCINE文献大全abstract：:We sought to determine the vaccine effectiveness (VE) of Lanzhou lamb rotavirus (LLR) vaccine against rotavirus gastroenteritis in children <5 requiring hospitalization. Children hospitalized 2002-2004 with rotavirus gastroenteritis were matched by gender, age and community to 838 controls. VE was calculated for one o...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2007.10.036
更新日期：2007-12-17 00:00:00
abstract：:Formalin-killed Streptococcus difficile strains used as vaccines delivered intraperitoneally were able to protect tilapia against a challenge of 100 LD50. The protection obtained was not strain specific. A vaccine based on an S. difficile extract containing 50% protein conjugated to alum also protected tilapia challen...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/0264-410x(94)00067-w
更新日期：1995-06-01 00:00:00
abstract：BACKGROUND:A recent mumps outbreak in Israel despite an ongoing national program of a 2-dose universal childhood vaccination policy since 1988, raised questions regarding population immunity among young adults. OBJECTIVE:To assess the seroprevalence of mumps antibodies among young Israeli adults born after 1987 in ord...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2011.01.103
更新日期：2011-03-24 00:00:00
abstract：:Since many years Afssaps applies the 3R's strategy (replacement, reduction and refinement) for the use of laboratory animal testing in the framework of vaccine batch release. In this context, for Hepatitis A vaccines, a study was carried out to assess the feasibility of replacing the in vivo "Gold Standard" potency as...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2009.12.006
更新日期：2010-02-17 00:00:00
abstract：:Dendritic cells (DCs) are highly specialized antigen-presenting cells of the immune system that are efficient at presenting peptide-antigen for the activation of T cells and are often the cell type of choice for vaccine targeting by virtue of high expression levels of MHC and costimulatory molecules. Since the level o...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2008.02.025
更新日期：2008-06-13 00:00:00
abstract：:Three doses of hepatitis B vaccine were given at 2, 4 and 9 months of age to 220 Senegalese infants living in the Dakar area of Senegal. Half of the infants received 5 micrograms plasma-derived hepatitis B vaccine (Hevac B) and the remainder 20 micrograms mammalian cell-derived recombinant hepatitis B vaccine (GenHeva...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/0264-410x(92)90067-t
更新日期：1992-01-01 00:00:00
abstract：:We have previously described the generation of HIV-1 V3-specific cytotoxic T-lymphocytes (CTL) responses in BALB/c (H-2d) mice following immunization with Ty-virus-like particles carrying the V3 loop of gp120 (V3-VLPs) without adjuvant. In this study the effects of various adjuvants on CTL induction by V3-VLPs was exa...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/0264-410x(96)00010-2
更新日期：1996-07-01 00:00:00
abstract：:Three vaccines, BCG alone, BCG + 10(7) killed Mycobacterium vaccae and 10(8) killed M. vaccae alone, were studied in children living in close contact with leprosy. In the year before vaccination, 14/446 (3.1%) children had developed leprosy. Among those who were not vaccinated, 9/74 (12.2%) developed the disease in th...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(01)00052-4
更新日期：2001-05-14 00:00:00
abstract：BACKGROUND:Inactivated quadrivalent influenza vaccine (IIV4) containing two influenza A strains and one strain from each B lineage (Yamagata and Victoria) may offer broader protection against seasonal influenza than inactivated trivalent influenza vaccine (IIV3), containing a single B strain. This study examined the sa...
journal_title：Vaccine
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.vaccine.2015.03.065
更新日期：2015-05-15 00:00:00
abstract：:Neisseria meningitidis is an important cause of bacterial meningitis and septicaemia with most disease caused by meningococci bearing serogroups A, B, C, Y and W-135 polysaccharides. Monovalent serogroup C conjugate vaccines have become established in the immunisation programmes in many countries and the first quadriv...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/j.vaccine.2009.05.003
更新日期：2009-06-24 00:00:00
abstract：INTRODUCTION:During the 2018-2019 influenza season, vaccination coverage among U.S. children was 62.6%. The purpose of this study was to estimate the prevalence of influenza vaccinations among pediatric patients seen in U.S. health centers, and to explore potential disparities in vaccination coverage among subpopulatio...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2020.07.021
更新日期：2020-09-03 00:00:00
abstract：:Measles transmission has been well documented in healthcare facilities. Healthcare personnel who are unvaccinated and who lack other evidence of measles immunity put themselves and their patients at risk for measles. We conducted a systematic literature review of measles vaccination policies and their implementation i...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/j.vaccine.2013.11.005
更新日期：2014-08-27 00:00:00
abstract：INTRODUCTION:Since the launch of the Global Polio Eradication Initiative (GPEI) in 1988, there has been a tremendous progress in the reduction of cases of poliomyelitis. The world is on the verge of achieving global polio eradication and in May 2013, the 66th World Health Assembly endorsed the Polio Eradication and End...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2016.05.060
更新日期：2016-10-10 00:00:00
abstract：:Simpler schedules for human papillomavirus (HPV) vaccine delivery could improve vaccine coverage and the effectiveness of cervical cancer prevention. The objective of this study was to systematically review evidence about the effects of two-dose compared with three-dose schedules for human papillomavirus (HPV) vaccine...
journal_title：Vaccine
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.vaccine.2017.03.096
更新日期：2017-05-19 00:00:00
abstract：:The ability of bioinformatics to characterize genomic sequences from pathogenic bacteria for prediction of genes that may encode vaccine candidates, e.g. surface localized proteins, has been evaluated. By applying appropriate tools for genomic mining to the published sequence of Haemophilus influenzae Rd genome, it wa...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(00)00256-5
更新日期：2000-11-08 00:00:00
abstract：OBJECTIVES:To assess the effectiveness and cost-effectiveness of routine childhood vaccination by new vaccines against rotavirus in France. METHODS:We constructed a Markov decision tree to compare two alternatives: "no vaccination" and "vaccination". A hypothetical birth cohort of 750,000 children was followed until 3...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2007.11.064
更新日期：2008-01-30 00:00:00
abstract：:To identify Mycobacterium tuberculosis (Mtb) antigens as candidates for a subunit vaccine against tuberculosis (TB), we have employed a CD4+ T-cell expression screening method. Mtb-specific CD4+ T-cell lines from nine healthy PPD positive donors were stimulated with different antigenic substrates including autologous ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2008.10.056
更新日期：2009-01-07 00:00:00
abstract：:DNA vaccination with plasmid has conventionally involved vectors designed for transient expression of antigens in injected tissues. Next generation plasmids are being developed for site-directed integration of transgenes into safe sites in host genomes and may provide an innovative approach for stable and sustained ex...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2014.01.063
更新日期：2014-03-26 00:00:00
abstract：:The objective of the present study was to investigate the feasibility of a subunit vaccine and a live bacteria vaccine to protect chickens against infectious bursal disease virus (IBDV) infection. The gene for VP2 of a new wild-type very virulent IBDV (vvIBDV) strain was cloned into an Escherichia coli expression syst...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2005.05.015
更新日期：2005-09-23 00:00:00
abstract：:We examined the prevalence of rubella antibodies in a representative sample of the Israeli population. Three thousand three hundred and twenty-six sera collected during 1997 and 1998, from an age-stratified general population sample were tested for specific IgG antibodies against rubella. The sero-positivity rates to ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2006.04.024
更新日期：2006-07-07 00:00:00
abstract：BACKGROUND:A series of state-level statute changes have allowed pharmacists to provide influenza vaccinations in community pharmacies. The study aim was to estimate the effects of pharmacy-based immunization statutes changes on per capita influenza vaccine prescriptions, adult vaccination rates, and the utilization of ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2016.04.076
更新日期：2016-06-24 00:00:00
abstract：BACKGROUND:Several concepts are available to explain vaccine decision making by individual and inter-individual factors, including risk perception, social conformism and altruism. However, only a few studies have quantified the weight of these determinants in vaccine acceptance. Using a conjoint analysis tool, we aimed...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2017.03.086
更新日期：2017-05-09 00:00:00
abstract：INTRODUCTION:Nosocomial outbreaks of seasonal influenza are frequent, and vaccination is largely recommended for healthcare workers (HCWs). Vaccine coverage in French HCWs does not exceed 20%. Decision-aids (DA) are potential useful interventions to increase vaccine coverage (VC). Our aim was to evaluate the impact of ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2020.07.011
更新日期：2020-08-10 00:00:00
abstract：:Availability of vaccines may be temporarily affected by sudden peak demand, coming on top of the vast increases of regular demand that the world has witnessed; this must be addressed by sound planning, and flexibility both from manufacturers and users. Temporary shortages are not structural in nature, and capacity is ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/0264-410x(92)90333-f
更新日期：1992-01-01 00:00:00
abstract：BACKGROUND:Diabetes is associated with higher risk of hospitalization, morbidity, and mortality from influenza. We assessed influenza vaccination coverage among adults aged ≥ 18 years with diabetes during the 2007-08 through 2017-18 influenza seasons and identified factors independently associated with vaccination duri...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2020.08.008
更新日期：2020-09-29 00:00:00
abstract：:Yellow fever is an acute infectious disease caused by prototype virus of the genus Flavivirus. It is endemic in Africa and South America where it represents a serious public health problem causing epidemics of hemorrhagic fever with mortality rates ranging from 20% to 50%. There is no available antiviral therapy and v...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2015.03.077
更新日期：2015-08-20 00:00:00
abstract：BACKGROUND:Adolescent HPV vaccination in minority and low income populations with high cervical cancer incidence and mortality could reduce disparities. Safety-net primary care clinics are a key delivery site for improving vaccination rates in these populations. PURPOSE:To examine prevalence of HPV initiation (≥ 1 dos...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2011.11.031
更新日期：2012-03-16 00:00:00
abstract：BACKGROUND:In 2008, China introduced live, attenuated hepatitis A vaccine (L-HepA, licensed in 1992) and inactivated hepatitis A vaccine (I-HepA, licensed in 2002) nationwide, and is currently the only country using L-HepA in routine immunization. We assessed seropositivity and its duration following vaccination, safet...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2020.11.019
更新日期：2020-12-14 00:00:00
abstract：BACKGROUND:New, more effective vaccines to prevent tuberculosis (TB) disease are needed urgently. H4:IC31 is an investigational vaccine that contains a fusion protein of the immunodominant antigens TB10.4 and Ag85B, formulated in IC31 adjuvant. We assessed the safety and immunogenicity of H4:IC31 in South African adult...
journal_title：Vaccine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.vaccine.2015.05.036
更新日期：2015-07-09 00:00:00
abstract：:Peptidoglycan monomer (PGM) originating from Brevibacterium divaricatum is a non-toxic, non-pyrogenic, water-soluble immunostimulator. It potentiates humoral immune response to ovalbumin (OVA) in mice upregulating both immunoglobulin (IgG) 1 and IgG2a antibody subclasses. This study concerns the influence of PGM on T ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(02)00336-5
更新日期：2002-10-04 00:00:00
