Availability of quality vaccines: the industrial point of view.

abstract：PURPOSE:The aims of this study are to evaluate the impact of a novel immunization curriculum based on the Preferred Cognitive Styles and Decision Making Model (PCSDM) on internal medicine (IM) resident continuity clinic patient panel immunization rates, as well as resident immunization knowledge, attitudes, and practic...

journal_title：Vaccine

authors： Whitaker JA,Poland CM,Beckman TJ,Bundrick JB,Chaudhry R,Grill DE,Halvorsen AJ,Huber JM,Kasten MJ,Mauck KF,Mehta RA,Olson T,Thomas KG,Thomas MR,Virk A,Wingo MT,Poland GA

更新日期：2018-03-27 00:00:00

abstract：:Despite the availability of anti-microbial agents effective against Neisseria meningitidis, meningococcal disease continues to be a major global health problem, particularly in the very young. Serogroup A meningococci cause large epidemics in sub-Saharan Africa, whilst serogroups B and C organisms are responsible for ...

journal_title：Vaccine

authors： Borrow R,Balmer P,Miller E

更新日期：2005-03-18 00:00:00

abstract：:Haemophilus parasuis (H. parasuis) is a swine pathogen responsible for the Glässer's disease, which has received more attention in the past decade due to the increasing economic losses in the pig industry worldwide. As traditional inactive vaccine of H. parasuis has obvious disadvantage, to identify efficient immunopr...

journal_title：Vaccine

authors： Li M,Song S,Yang D,Li C,Li G

更新日期：2015-03-30 00:00:00

abstract：INTRODUCTION:HIV seropositivity is considered a risk factor for complications in hepatitis A virus (HAV) infection. HAV vaccination schedules are widely implemented in HIV-infected patients, but the immune response remains impaired. METHODS:We analysed the response to vaccination (antiHAV titres ≥20IU/l) in 282 HIV-in...

journal_title：Vaccine

authors： Mena G,García-Basteiro AL,Llupià A,Díez C,Costa J,Gatell JM,García F,Bayas JM

更新日期：2013-08-12 00:00:00

abstract：:During the endgame of global polio eradication, the universal introduction of inactivated poliovirus vaccines is urgently required to reduce the risk of vaccine-associated paralytic poliomyelitis and polio outbreaks due to wild and vaccine-derived polioviruses. In particular, the development of inactivated poliovirus ...

journal_title：Vaccine

authors： Shimizu H

更新日期：2016-04-07 00:00:00

abstract：:The recombinant vaccinia viruses expressing the surface protein of Neospora caninum tachyzoite, NcSAG1 or NcSRS2, were constructed. The vaccination with these recombinant viruses could protect effectively the parasite invasion in a mouse model system. The vaccine efficacy of NcSRS2 was higher than that of NcSAG1. The ...

journal_title：Vaccine

authors： Nishikawa Y,Inoue N,Xuan X,Nagasawa H,Igarashi I,Fujisaki K,Otsuka H,Mikami T

更新日期：2001-01-08 00:00:00

abstract：OBJECTIVES:Using dynamic transmission models we evaluated the health and cost outcomes of adding acellular pertussis (aP) vaccination of pregnant women to infant vaccination in three Brazilian states that represent different socioeconomic conditions. The primary objective was to determine whether the same model structu...

journal_title：Vaccine

authors： Luz PM,Struchiner CJ,Kim SY,Minamisava R,Andrade ALS,Sanderson C,Russell LB,Toscano CM

更新日期：2021-01-03 00:00:00

abstract：:Plague, which is initiated by Yersinia pestis infection, is a fatal disease that progresses rapidly and leads to high mortality rates if not treated. Antibiotics are an effective plague therapy, but antibiotic-resistant Y. pestis strains have been reported and therefore alternative countermeasures are needed. In the p...

journal_title：Vaccine

authors： Levy Y,Flashner Y,Tidhar A,Zauberman A,Aftalion M,Lazar S,Gur D,Shafferman A,Mamroud E

更新日期：2011-09-16 00:00:00

abstract：:Activation of the innate immune system by different homotopes may direct the subsequent specific immune response, and as a consequence may have significant implications on vaccination. In this study, effects of i.v. administered lipopolysaccharide (LPS), and lipoteichoic acid (LTA), respectively, and s.c. administered...

journal_title：Vaccine

authors： Maldonado LM,Lammers A,Nieuwland MG,De Vries Reilingh G,Parmentier HK

更新日期：2005-04-15 00:00:00

abstract：:Recombinant poxviruses are well suited for the development of new vaccine vectors. Our previous data supported the idea that Myxomavirus (MYXV) is efficient at priming antibody responses in sheep. To provide definitive evidence on the potential of MYXV for vaccination against infectious diseases in ruminants, we inves...

journal_title：Vaccine

authors： Top S,Foucras G,Deplanche M,Rives G,Calvalido J,Comtet L,Bertagnoli S,Meyer G

更新日期：2012-02-21 00:00:00

abstract：:Mice immunized with plasmid DNA encoding Nef regulatory protein of human immunodeficiency virus type 1 developed high levels of anti-Nef antibodies. After 4 intramuscular injections of 100 microg plasmid DNA, anti-Nef antibodies reached titers up to 2 x 10(4). A significant specific antibody response was maintained fo...

journal_title：Vaccine

authors： Moureau C,Moynier M,Kavsan V,Montagnier L,Bahraoui E

更新日期：1999-09-01 00:00:00

abstract：:In Japan, trivalent inactivated influenza vaccine is the only approved influenza vaccine. It is typically administrated by hypodermic injection, and children under 13 years of age are recommended to be vaccinated two times during each winter season. Live-attenuated influenza vaccine (LAIV) is administered by a thimero...

journal_title：Vaccine

authors： Shono A,Kondo M

更新日期：2014-09-03 00:00:00

abstract：:The expression and secretion of pertussis toxin subunits S1 to S5 in Bacillus subtilis by the aid of a bacillary signal sequence has been reported. While secretion of subunit S1 was high, that of others was low. Ways have now been explored to improve the yield, using S4 as an example. The addition of a protease inhibi...

journal_title：Vaccine

authors： Himanen JP,Taira S,Sarvas M,Saris P,Runeberg-Nyman K

更新日期：1990-12-01 00:00:00

abstract：:The PEDVAC study is the first trial designed to analyze safety and immunogenicity of a therapeutic vaccination with a multiclade multigene HIV DNA vaccine (HIVIS) in infected children. Twenty HIV-1 vertically infected children (6-16 years of age), on stable antiretroviral treatment for at least 6 months with HIV-1 RNA...

journal_title：Vaccine

authors： Palma P,Romiti ML,Li Pira G,Montesano C,Mora N,Aquilani A,Santilli V,Tchidjou HK,Ivaldi F,Giovannelli L,Pontrelli G,Borra G,Blomberg P,Gudmundsdotter L,Bråve A,Montano M,Bernardi S,Manca F,Wahren B,Rossi P

更新日期：2011-09-09 00:00:00

abstract：:DNA isolates from a number of established cell lines have been tested for their transforming capacity in the NIH3T3 transformation assay. It has been found that this assay can be used to quantify the amount of transforming DNA at a submicrogram to milligram level. This assay system has been applied to validate the red...

journal_title：Vaccine

authors： van Meel FC,Steenbakkers PG,Bos E

更新日期：1985-12-01 00:00:00

abstract：:Haemagglutinin (HA), a mixture of haemagglutinin and neuraminidase (HA + NA), and matrix (M) protein were isolated from the influenza A virus and covalently coupled to a synthetic polyelectrolyte (P). A single injection into mice of the resultant conjugates (virogates) brought about efficient stimulation of the primar...

journal_title：Vaccine

authors： Petrov RV,Khaitov RM,Zhdanov VM,Sinyakov MS,Norimov ASh,Nekrasov AV,Podchernyaeva RYa,Kharitonenkov IG,Shchipanova MV

更新日期：1985-12-01 00:00:00

abstract：:A reverse transcriptase polymerase chain reaction (PCR) was used to amplify a 235 bp hypervariable region of the feline calicivirus (FCV) genome which encodes part of the capsid protein. Sequence from this region was used to compare viruses used in three attenuated vaccines to viruses isolated from vaccinated cats wit...

journal_title：Vaccine

authors： Radford AD,Bennett M,McArdle F,Dawson S,Turner PC,Glenn MA,Gaskell RM

更新日期：1997-08-01 00:00:00

abstract：:CD1d-binding glycolipids exert potent adjuvant effects on T-dependent Ab responses. The mechanisms include cognate interaction between CD1d-expressing B cells and TCR-expressing Type I CD1d-restricted natural killer T cells (NKTs). However, the critical NKT-derived factors that stimulate B cells are poorly understood....

journal_title：Vaccine

authors： Shah HB,Joshi SK,Lang ML

更新日期：2011-11-15 00:00:00

abstract：:Bacterial flagellin activates the innate immune system and ultimately the adaptive immune system through a Toll-like receptor 5 (TLR5)-dependent signaling mechanism. Given that TLR5 is widely distributed in epithelia, flagellin is currently being developed as a mucosal adjuvant. Flagellin FliC from Salmonella enterica...

journal_title：Vaccine

authors： Biedma ME,Cayet D,Tabareau J,Rossi AH,Ivičak-Kocjan K,Moreno G,Errea A,Soulard D,Parisi G,Jerala R,Berguer P,Rumbo M,Sirard JC

更新日期：2019-01-21 00:00:00

abstract：BACKGROUND:The objective of this study was to estimate the number of years after onset of a quadrivalent HPV vaccination program before notable reductions in genital warts and cervical intraepithelial neoplasia (CIN) will occur in teenagers and young adults in the United States. METHODS:We applied a previously publish...

journal_title：Vaccine

authors： Chesson HW,Ekwueme DU,Saraiya M,Dunne EF,Markowitz LE

更新日期：2013-08-20 00:00:00

abstract：INTRODUCTION:Vaccination of health care workers (HCW) reduces transmission of influenza among patients, yet uptake of vaccination remains low. If vaccination education is integrated into the early medical school curriculum, will student attitudes toward the vaccine change? The objectives of the study were to: (1) Deter...

journal_title：Vaccine

authors： Afonso N,Kavanagh M,Swanberg S

更新日期：2014-01-16 00:00:00

abstract：:The development of strategies to augment the immunogenicity of plasmid DNA vaccines is critical for improving their clinical utility. One such strategy involves the coadministration of plasmid cytokine adjuvants with DNA vaccines. Although a large number of plasmid cytokines have shown promise as adjuvants in preclini...

journal_title：Vaccine

authors： Barouch DH,Truitt DM,Letvin NL

更新日期：2004-08-13 00:00:00

abstract：:To circumvent limitations of poor antigen presentation and immunogenicity of DNA vaccines that target induction of CD8(+) T cell immunity, we have generated single chain MHC I trimers (MHC I SCTs) composed of a single polypeptide chain with a linear composition of antigenic peptide, β2-microglobulin, and heavy chain o...

journal_title：Vaccine

authors： Kim S,Zuiani A,Carrero JA,Hansen TH

更新日期：2012-03-09 00:00:00

abstract：:Interest is increasing regarding replicating poxvirus as HIV vaccine vector. In China, the Tiantan Vaccinia Virus (TV) has been used most extensively in the battle of eradicating smallpox. Recently, TV was developing as vaccine vector to fight against infectious diseases such as human immunodeficiency virus (HIV). How...

journal_title：Vaccine

authors： Dai K,Liu Y,Liu M,Xu J,Huang W,Huang X,Liu L,Wan Y,Hao Y,Shao Y

更新日期：2008-09-15 00:00:00

abstract：:Previously, we showed that vaccination with the glycoprotein D (gD) gene of pseudorabies virus (PrV) delivered by Escherichia coli induced protective immune responses. In this study, we report that oral DNA vaccination with attenuated Salmonella choleraesuis carrying the PrV gD gene conferred protective immunity in mi...

journal_title：Vaccine

authors： Shiau AL,Chen YL,Liao CY,Huang YS,Wu CL

更新日期：2001-07-16 00:00:00

abstract：BACKGROUND:Sexual mixing between heterogeneous population subgroups is an integral component of mathematical models of sexually transmitted infections (STIs). This study compares the fit of different mixing representations to survey data and the impact of different mixing assumptions on the predicted benefits of hypoth...

journal_title：Vaccine

authors： Easterly CW,Alarid-Escudero F,Enns EA,Kulasingam S

更新日期：2018-09-05 00:00:00

abstract：:The hypervariable region 1 (HVR1) of hepatitis C virus (HCV) may contain neutralizing epitopes. A chimpanzee in whom cross-reactive anti-HVR1 antibodies had been induced by immunization was challenged with heterologous HCV for clarifying whether cross-reactive anti-HVR1 antibodies can neutralize heterologous HCV. Acut...

journal_title：Vaccine

authors： Esumi M,Zhou YH,Tanoue T,Tomoguri T,Hayasaka I

更新日期：2002-08-19 00:00:00

abstract：:The glutamate-rich protein (GLURP) of P. falciparum is the target of cytophilic antibodies which are significantly associated with protection against clinical malaria. A phase 1 clinical trial was conducted in healthy adult volunteers with the long synthetic peptide (LSP) GLURP(85-213) combined with either Aluminum Hy...

journal_title：Vaccine

authors： Hermsen CC,Verhage DF,Telgt DS,Teelen K,Bousema JT,Roestenberg M,Bolad A,Berzins K,Corradin G,Leroy O,Theisen M,Sauerwein RW

更新日期：2007-04-12 00:00:00

abstract：:The cattle tick, Rhipicephalus microplus, is regarded as the most economically important ectoparasite of livestock globally. Control is achieved primarily through the use of acaricides. This approach is hampered by the development of resistance to commercial acaricides among cattle tick populations. Vaccination agains...

journal_title：Vaccine

authors： Andreotti R,Cunha RC,Soares MA,Guerrero FD,Leite FP,de León AA

更新日期：2012-10-19 00:00:00

abstract：BACKGROUND:Several chronic disease states have been identified as pneumococcal vaccination indications due to their ability to increase pneumococcal disease development and subsequent mortality. However, the risk of mortality according to the number of these disease states present is unknown. We sought to determine the...

journal_title：Vaccine

authors： Morton JB,Morrill HJ,LaPlante KL,Caffrey AR

更新日期：2017-03-23 00:00:00