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Protective efficacy of vaccination by recombinant vaccinia virus against Neospora caninum infection.

Abstract：

:The recombinant vaccinia viruses expressing the surface protein of Neospora caninum tachyzoite, NcSAG1 or NcSRS2, were constructed. The vaccination with these recombinant viruses could protect effectively the parasite invasion in a mouse model system. The vaccine efficacy of NcSRS2 was higher than that of NcSAG1. The present study indicated that a high level of IgG1 Ab production to parasite is important for clearance of parasite at the early stage of infection and that T cell response has a crucial role for protection against the intracellular infection at the late stage of infection. The recombinant vaccinia viruses might be applicable as vaccine against N. caninum infection in a natural host.

journal_name

Vaccine

journal_title

Vaccine

authors

Nishikawa Y,Inoue N,Xuan X,Nagasawa H,Igarashi I,Fujisaki K,Otsuka H,Mikami T

doi

10.1016/s0264-410x(00)00389-3

subject

Has Abstract

pub_date

2001-01-08 00:00:00

pages

1381-90

issue

11-12

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(00)00389-3

journal_volume

19

pub_type

杂志文章

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