Abstract：
:Nasal administration of vaccines is an attractive approach which offers several significant advantages over traditional intramuscular vaccine delivery. These advantages include easier administration and induction of immune responses in the mucosal secretions of the body. In this study we describe a new potent nasal adjuvant, dimethyldioctadecylammonium bromide (DDA), that induces both mucosal and systemic immune responses when co-administered with diphtheria toxoid (DT), tetanus toxoid (TT) and BBG2Na antigens. In particular, we show that the nasal delivery of recombinant fragment (BBG2Na) of the G protein of respiratory syncytial virus (RSV) mixed with DDA induces both local and systemic anti-RSV immune responses and protects against viral challenge. Furthermore, we provide evidence that the DDA+BBG2Na vaccine does not induce lung immunopathology upon subsequent RSV challenge.
journal_name
Vaccinejournal_title
Vaccineauthors
Klinguer C,Beck A,De-Lys P,Bussat MC,Blaecke A,Derouet F,Bonnefoy JY,Nguyen TN,Corvaïa N,Velin Ddoi
10.1016/s0264-410x(01)00156-6subject
Has Abstractpub_date
2001-07-20 00:00:00pages
4236-44issue
30eissn
0264-410Xissn
1873-2518pii
S0264-410X(01)00156-6journal_volume
19pub_type
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