Abstract:
:Active surveillance was conducted by the 12 centers of the Canadian Immunization Monitoring Program, Active from 2000-2007 in children 16 years of age and younger to determine the influence of 7-valent pneumococcal conjugate immunization programs on the prevalence, serotype and antibiotic resistance patterns of invasive pneumococcal disease (IPD) caused by Streptococcus pneumoniae. The absolute number of reported IPD cases decreased 48% (p<0.01) over the 8-year period and 56% (p<0.01) in children 0-4 years of age. The absolute number of reported IPD cases caused by serotypes in the conjugate vaccine decreased 87.5% (p<0.01) overall and 92% (p<0.01) in children 0-4 years. Although 6 non-vaccine serotypes increased over time, only serotype 19A increased significantly (p<0.01). Overall, the proportion of penicillin resistant isolates remained unchanged at 17%. Cefotaxime/ceftriaxone resistance remained unchanged at 2% of isolates annually. Universal pneumococcal conjugate infant immunization programs have dramatically decreased cases of invasive pneumococcal disease.
journal_name
Vaccinejournal_title
Vaccineauthors
Bettinger JA,Scheifele DW,Kellner JD,Halperin SA,Vaudry W,Law B,Tyrrell G,Canadian Immunization Monitoring Program, Active (IMPACT).doi
10.1016/j.vaccine.2009.12.026subject
Has Abstractpub_date
2010-02-25 00:00:00pages
2130-6issue
9eissn
0264-410Xissn
1873-2518pii
S0264-410X(09)01930-6journal_volume
28pub_type
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