Future approaches to vaccine development: single-dose vaccines using controlled-release delivery systems.

abstract：BACKGROUND:The compliance with influenza vaccination among health-care workers (HCWs) is known to be low. A multi-nationality survey to explore the reasons for such poor compliance has not been studied in depth. MATERIALS AND METHODS:An epidemiologic survey to evaluate the compliance rates with influenza vaccination a...

journal_title：Vaccine

authors： Al-Tawfiq JA,Antony A,Abed MS

更新日期：2009-09-04 00:00:00

abstract：BACKGROUND:We have developed a new oral vaccine against enterotoxigenic Escherichia coli (ETEC), which is the most common cause of bacterial diarrhea in children in developing countries and in travelers. METHODS:The vaccine was tested for safety and immunogenicity alone and together with double-mutant heat-labile toxi...

journal_title：Vaccine

authors： Lundgren A,Bourgeois L,Carlin N,Clements J,Gustafsson B,Hartford M,Holmgren J,Petzold M,Walker R,Svennerholm AM

更新日期：2014-12-12 00:00:00

abstract：:The vast majority of women infected with human immunodeficiency virus (HIV) will be co-infected with human papillomavirus (HPV). The interaction between the two sexually transmitted infections appears to be related to the alteration in cell-mediated immunity in HIV infected persons, increased susceptibility, and possi...

journal_title：Vaccine

authors： Denny LA,Franceschi S,de Sanjosé S,Heard I,Moscicki AB,Palefsky J

更新日期：2012-11-20 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Public concern about an unsubstantiated link between MMR vaccine and autism stemmed from a 1998 paper by Dr Andrew Wakefield and colleagues, and the substantial media coverage which that work attracted. Though the Wakefield paper is now discredited and an MMR-autism link has never been demonst...

journal_title：Vaccine

authors： Brown KF,Long SJ,Ramsay M,Hudson MJ,Green J,Vincent CA,Kroll JS,Fraser G,Sevdalis N

更新日期：2012-02-27 00:00:00

abstract：:After decades of inconsequential infections, and sporadic outbreaks in the Asia-Pacific region between 2007 and 2013, Zika virus caused a widespread epidemic in South America in 2015 that was complicated by severe congenital infections. After the WHO declared a Public Health Emergency of International Concern in Febru...

journal_title：Vaccine

authors： Lecouturier V,Bernard MC,Berry C,Carayol S,Richier E,Boudet F,Heinrichs J

更新日期：2019-05-06 00:00:00

abstract：:Mucosal immunization with a killed whole-cell pneumococcal vaccine, given with enterotoxin-related adjuvants, has been shown to confer multi-serotype protection against colonization of the nasopharynx and middle ear in mice. However, because novel mucosal immunization strategies may be difficult to implement, here we ...

journal_title：Vaccine

authors： Lu YJ,Leite L,Gonçalves VM,Dias Wde O,Liberman C,Fratelli F,Alderson M,Tate A,Maisonneuve JF,Robertson G,Graca R,Sayeed S,Thompson CM,Anderson P,Malley R

更新日期：2010-11-03 00:00:00

abstract：INTRODUCTION:Widespread introduction of pneumococcal conjugated vaccines (PCVs) impacted on invasive pneumococcal disease (IPD). However, IPD reduction may not be similar in all outcomes within IPD. We assessed PCV7/PCV13 impact on pneumococcal meningitis, bacteremic pneumonia (BP) and other (non-meningitis, non-pneumo...

journal_title：Vaccine

authors： Ben-Shimol S,Givon-Lavi N,Grisaru-Soen G,Megged O,Greenberg D,Dagan R,Israel Bacteremia and Meningitis Active Surveillance Group.

更新日期：2018-08-28 00:00:00

abstract：:Current infant vaccination against pertussis in North America and Australia requires three doses of vaccines including diphtheria, tetanus and acellular pertussis antigens (DTaP) at 2, 4 and 6 months of age. Interest is growing in the possibility that vaccination at birth might provide earlier protection of infants, b...

journal_title：Vaccine

authors： White OJ,Rowe J,Richmond P,Marshall H,McIntyre P,Wood N,Holt PG

更新日期：2010-03-19 00:00:00

abstract：:The critical first step in the clinical development of a malaria vaccine, based on live-attenuated Plasmodium falciparum sporozoites, is the guarantee of complete arrest in the liver. We report on an approach for assessing adequacy of attenuation of genetically attenuated sporozoites in vivo using the Plasmodium bergh...

journal_title：Vaccine

authors： Annoura T,Ploemen IH,van Schaijk BC,Sajid M,Vos MW,van Gemert GJ,Chevalley-Maurel S,Franke-Fayard BM,Hermsen CC,Gego A,Franetich JF,Mazier D,Hoffman SL,Janse CJ,Sauerwein RW,Khan SM

更新日期：2012-03-30 00:00:00

abstract：:Eight different vaccination schemes using four commercially available inactivated Bluetongue vaccines against serotypes 4 and 8 in three different combinations (setting 1-3) were tested under field conditions for their ability to generate a measurable immune response in sheep. Animals of setting 1 (groups A-D) were si...

journal_title：Vaccine

authors： Hilke J,Strobel H,Woelke S,Stoeter M,Voigt K,Grimm L,Meilwes J,Punsmann T,Blaha I,Salditt A,Rohn K,Bastian M,Ganter M

更新日期：2019-09-16 00:00:00

abstract：:Protection against Schistosoma mansoni infection in C57BL/6 female mice was evaluated by two DNA vaccination strategies. Mice were either vaccinated by intramuscular injection with pcDNAI/Amp constructs encoding either Cu/Zn cytosolic superoxide dismutase (CT-SOD), signal peptide-containing SOD (SP-SOD), glutathione p...

journal_title：Vaccine

authors： Shalaby KA,Yin L,Thakur A,Christen L,Niles EG,LoVerde PT

更新日期：2003-12-08 00:00:00

abstract：:Delayed-type hypersensitivity (DTH) response to arthropod vector salivary proteins is associated with protection against pathogen transmission. Massive cDNA sequencing, high-throughput DNA plasmid construction and DNA immunisation were used to identify twelve DTH inducing proteins isolated from a Phlebotomus ariasi sa...

journal_title：Vaccine

authors： Oliveira F,Kamhawi S,Seitz AE,Pham VM,Guigal PM,Fischer L,Ward J,Valenzuela JG

更新日期：2006-01-16 00:00:00

abstract：:Three separate studies were undertaken in HIV-1 uninfected persons to determine if the adjuvant QS-21 improves the magnitude or kinetics of immune responses induced by recombinant soluble gp120 HIV-1(MN) protein (rsgp120) immunization. The QS-21 was administered at two doses (50 and 100 microg), either alone or in com...

journal_title：Vaccine

authors： Evans TG,McElrath MJ,Matthews T,Montefiori D,Weinhold K,Wolff M,Keefer MC,Kallas EG,Corey L,Gorse GJ,Belshe R,Graham BS,Spearman PW,Schwartz D,Mulligan MJ,Goepfert P,Fast P,Berman P,Powell M,Francis D,NIAID AIDS V

更新日期：2001-02-28 00:00:00

abstract：BACKGROUND:High incidence and serotype diversity of invasive pneumococcal disease (IPD) in Indigenous children in remote Australia led to rapid introduction of 7-valent conjugate pneumococcal vaccine (7vPCV) at 2, 4 and 6 months in 2001, followed by 23-valent polysaccharide pneumococcal vaccine (23vPPV) in the second y...

journal_title：Vaccine

authors： Jayasinghe S,Chiu C,Menzies R,Lehmann D,Cook H,Giele C,Krause V,McIntyre P

更新日期：2015-11-27 00:00:00

abstract：:This article presents the World Health Organization's (WHO) recommendations for the use of vaccines against diseases caused by human papillomaviruses (HPV) from the WHO position paper on Human papillomavirus vaccines: WHO position paper - October 2014, recently published in the Weekly Epidemiological Record [1]. This ...

journal_title：Vaccine

authors：

更新日期：2015-08-26 00:00:00

abstract：:Live cold-adapted recombinant bivalent vaccine of influenza type A was studied in a controlled field trial in 1982-1983 among nearly 30,000 children 3-15 years old. The bivalent vaccine consisted of recombinants 47/25/1 (H1N1) and 47/7/2 (H3N2) of wild-type viruses A/Brazil/11/78 (H1N1) and A/Bangkok/1/79 (H3N2) with ...

journal_title：Vaccine

authors： Alexandrova GI,Budilovsky GN,Koval TA,Polezhaev FI,Garmashova LM,Ghendon YuZ,Romanova YR,Smorodintsev AA

更新日期：1986-06-01 00:00:00

abstract：:Intranasal live attenuated influenza vaccine (LAIV) has potential for self-administration (SA) by adults and adolescents, which could save time and cost in mass vaccination settings. Participants in a study of LAIV in adults (n=4561) selected either SA or health care provider (HCP) administration and were followed for...

journal_title：Vaccine

authors： Ambrose CS,Wu X

更新日期：2013-01-30 00:00:00

abstract：:Mycobacterium w (Mw), is a cultivable, non-pathogenic mycobacterium and has been tried extensively as an immunomodulator in leprosy. This has been found to be safe and has shown beneficial immunoprophylactic effect in population based, double blind placebo controlled trials in North India. These effects were also obse...

journal_title：Vaccine

authors： Katoch K,Singh P,Adhikari T,Benara SK,Singh HB,Chauhan DS,Sharma VD,Lavania M,Sachan AS,Katoch VM

更新日期：2008-02-26 00:00:00

abstract：:Here, we evaluated the modulation of the immune response induced by Hsp90 of Nicotiana benthamiana (NbHsp90.3) against the Maltose Binding Protein (MBP) as a reporter antigen. Equimolar quantities of recombinant proteins were administered in mice as follows: MBP alone (MBP group), a mixture of MBP and rNbHsp90.3 (MBP+...

journal_title：Vaccine

authors： Corigliano MG,Fenoy I,Sander V,Maglioco A,Goldman A,Clemente M

更新日期：2013-12-02 00:00:00

abstract：:The immunogenicity and safety of an HPV-16/18 AS04-adjuvanted vaccine were assessed in women aged 26-55 years and compared with women aged 15-25 years in a Phase III, non-randomised, open-label, age-stratified study. Overall the vaccine was well tolerated and 100% seropositivity was achieved 1 month after the third do...

journal_title：Vaccine

authors： Schwarz TF,Spaczynski M,Schneider A,Wysocki J,Galaj A,Perona P,Poncelet S,Zahaf T,Hardt K,Descamps D,Dubin G,HPV Study Group for Adult Women.

更新日期：2009-01-22 00:00:00

abstract：BACKGROUND:Since special efforts are necessary to vaccinate people living far from fixed vaccination posts, decision makers are interested in knowing the economic value of such efforts. METHODS:Using our immunization geospatial information system platform and a measles compartment model, we quantified the health and e...

journal_title：Vaccine

authors： Lee BY,Brown ST,Haidari LA,Clark S,Abimbola T,Pallas SE,Wallace AS,Mitgang EA,Leonard J,Bartsch SM,Yemeke TT,Zenkov E,Ozawa S

更新日期：2019-04-17 00:00:00

abstract：BACKGROUND:Although guidelines for prophylactic human papillomavirus (HPV) vaccination recommend two doses for girls ages 9-14 years, several studies have demonstrated similar protection with one dose. Our objective was to evaluate the long-term health and economic impacts of routine one-dose HPV vaccination compared t...

journal_title：Vaccine

authors： Burger EA,Campos NG,Sy S,Regan C,Kim JJ

更新日期：2018-08-06 00:00:00

abstract：:In a large series of post-vaccination samples we compared the result of three commercially available anti-HBs assays (AxSYM, Architect and Access) on the quantitation of anti-HBs after immunisation with Engerix-B (HBsAg/ad) and GenHevacB (HBsAg/ay) vaccine. Two of the assays (AxSYM, Architect: Abbott Laboratories) gav...

journal_title：Vaccine

authors： Heijtink RA,Schneeberger PM,Postma B,Crombach W

更新日期：2002-07-26 00:00:00

abstract：:Serological surveys in many communities show a high prevalence of antibodies to hepatitis A virus (HAV) in people over the age of 50 years. However, few of that age can recall a previous episode of hepatitis, indicating that subclinical infections are common. The outcome of infection with HAV depends on the age at whi...

journal_title：Vaccine

authors： Gust ID

更新日期：1992-01-01 00:00:00

abstract：:Randomly selected 200 subjects were tested for quantitative hepatitis B surface antibody (HBsAb) estimation in a remote tribal area of Arunachal Pradesh, India to measure the protective immunity after vaccination in the backdrop of hyperendemic HBV infection. About 64.6 and 40.0% had HBsAb above 10 mIU/ml in the vacci...

journal_title：Vaccine

authors： Borkakoty B,Mahanta J,Biswas D

更新日期：2007-12-05 00:00:00

abstract：:Aeromonas hydrophila, as a strong Gram-negative bacterium, can infect a wide range of freshwater fish, including common carp Cyprinus carpio, and cause the huge economic loss. To create the effective vaccine is the best way to control the outbreak of the disease caused by A. hydrophila. In this study, a live attenuate...

journal_title：Vaccine

authors： Jiang X,Zhang C,Zhao Y,Kong X,Pei C,Li L,Nie G,Li X

更新日期：2016-06-08 00:00:00

abstract：BACKGROUND:Adolescent HPV vaccination in minority and low income populations with high cervical cancer incidence and mortality could reduce disparities. Safety-net primary care clinics are a key delivery site for improving vaccination rates in these populations. PURPOSE:To examine prevalence of HPV initiation (≥ 1 dos...

journal_title：Vaccine

authors： Tiro JA,Pruitt SL,Bruce CM,Persaud D,Lau M,Vernon SW,Morrow J,Skinner CS

更新日期：2012-03-16 00:00:00

abstract：:Currently, two intradermal (ID) regimens for rabies post-exposure prophylaxis (PEP) are recommended by WHO and used in countries where approved by national authorities: the Thai Red Cross (TRC) two-site ID regimen and the eight-site ID regimen. Besides these WHO recommended schedules, a new economical four-site ID reg...

journal_title：Vaccine

authors： Ambrozaitis A,Laiskonis A,Balciuniene L,Banzhoff A,Malerczyk C

更新日期：2006-05-08 00:00:00

abstract：:An N-terminal peptide of the HIV-1 fusion peptide (FP) with eight amino acid residues (FP8) was conjugated to a recombinant Tetanus Toxoid Heavy Chain Fragment C (rTTHc) as a carrier protein to help boosting immunogenicity against HIV-1. In this rapid communication, a unique algorithm to determine FP-rTTHc conjugation...

journal_title：Vaccine

authors： Yang GJ,Yang Y,Shaddeau A,Cai CX,Li Y,Gulla K,Zhang Y,Ou L,Cooper JW,Lei QP

更新日期：2020-06-15 00:00:00

abstract：:Organised and quality assured cytology-based screening programmes have substantially reduced cervical cancer incidence in many developed countries. However, there are considerable barriers to setting up cytology-based screening programs, particularly in developing countries. This has stimulated the search for novel an...

journal_title：Vaccine

authors： Denny L,Quinn M,Sankaranarayanan R

更新日期：2006-08-31 00:00:00