Abstract：
:In a large series of post-vaccination samples we compared the result of three commercially available anti-HBs assays (AxSYM, Architect and Access) on the quantitation of anti-HBs after immunisation with Engerix-B (HBsAg/ad) and GenHevacB (HBsAg/ay) vaccine. Two of the assays (AxSYM, Architect: Abbott Laboratories) gave related but not identical results with HBsAg from different sources. The result of the third assay (Access, Beckman Coulter) was related to that of AxSYM and Architect only for GenHevacB anti-HBs but differed for Engerix-B anti-HBs (P<0.001). This vaccine dependent discrepancy was also observed with the Vidas anti-HBs assay (BioMerieux). An external WHO reference panel could harmonise geometric mean anti-HBs levels from the four assays for GenHevacB but not for Engerix-B vaccination sera. We conclude that the individually determined anti-HBs level (IU/l) strongly depend on the test reagents and the vaccine under study.
journal_name
Vaccinejournal_title
Vaccineauthors
Heijtink RA,Schneeberger PM,Postma B,Crombach Wdoi
10.1016/s0264-410x(02)00233-5subject
Has Abstractpub_date
2002-07-26 00:00:00pages
2899-905issue
23-24eissn
0264-410Xissn
1873-2518pii
S0264410X02002335journal_volume
20pub_type
杂志文章相关文献
VACCINE文献大全abstract：:Tick-borne encephalitis (TBE) is a potentially serious disease, especially in adults. There is no treatment available for TBE; supportive therapy may help to ease symptoms of the disease. Vaccination is the most effective method of preventing TBE disease and is recommended for those who live, work, or travel in TBE-en...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2008.11.082
更新日期：2009-02-05 00:00:00
abstract：:HIV-1 Tat protein activates resting cells, rendering them permissive for viral replication. Replication of HIV-1 in vitro is enhanced by intercellular passage of Tat protein and inhibited by anti-Tat antibodies. Tat dependence of HIV-1 replication in vivo during acute, chronic asymptomatic and AIDS stages of infection...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(00)00085-2
更新日期：2000-06-15 00:00:00
abstract：:Immunization protocols based on priming with plasmid DNA and boosting with recombinants of vaccinia virus (rVV) encoding the same antigen offer great promise for the prevention and treatment of many parasitic and viral infections for which conventional vaccination has little or no effect. To overcome some of the poten...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(02)00450-4
更新日期：2002-12-13 00:00:00
abstract：INTRODUCTION:In 2009, girls-only HPV16/18 vaccination was introduced in the Netherlands which has achieved 46-61% uptake. Heterosexual men have benefitted from herd protection, but it is unknown whether men who have sex with men (MSM) also benefit from herd effects of the girls-only HPV16/18 vaccination program. Becaus...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2020.03.002
更新日期：2020-04-09 00:00:00
abstract：BACKGROUND:We report the first-in-concept human trial of the safety, tolerability and immunogenicity when a novel TLR 7/8/RIG I agonist RNA-based adjuvant, CV8102, was administered alone or mixed with fractional doses of a licensed rabies vaccine (Rabipur®) as model antigen. METHODS:The primary objective was to assess...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2019.02.024
更新日期：2019-03-22 00:00:00
abstract：:While the large majority of parents in the U.S. vaccinate their children according to the recommended immunization schedule, some parents have refused or delayed vaccinating, often citing safety concerns. In response to public concern, the U.S. Institute of Medicine (IOM) evaluated existing research regarding the safe...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2015.10.082
更新日期：2016-02-15 00:00:00
abstract：:A novel avian-origin influenza A H7N9 virus emerged in China in 2013 and continues to cause sporadic human infections with mortality rates approaching 35%. Currently there are no approved human vaccines for H7N9 virus. Recombinant approaches including hemagglutinin (HA) and virus-like particles (VLPs) have resulted in...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2015.07.026
更新日期：2015-09-11 00:00:00
abstract：:The assignment of infectious potency to test articles of adenovirus has been conducted mainly using classical end-point dilution methods, which rely on virus induced cytopathology to reveal the presence of infectious virus. These assays suffer the disadvantages of labor intensity, duration, throughput restriction and ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2005.04.023
更新日期：2005-08-22 00:00:00
abstract：:Lassa virus (LASV) is responsible for the deaths of thousands of people in West Africa annually. Genetic diversity among LASV strains is the highest among the Arenaviridae and represents a great challenge for vaccine development. Guinea pigs vaccinated with a ML29 reassortant vaccine experienced sterilizing immunity a...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2007.02.038
更新日期：2007-05-16 00:00:00
abstract：:Recombinant antigens from the oncosphere stage of the parasite Taenia solium were expressed in Escherichia coli. The TSOL16, TSOL45-1A and TSOL45-1B recombinant antigens, each consisting of fibronectin type III (FnIII) domain S, were produced as fusion proteins with glutathione S-transferase (GST) and maltose binding ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2012.04.019
更新日期：2012-06-06 00:00:00
abstract：:Pseudomonas aeruginosa antimicrobial resistance is a major therapeutic challenge. DNA vaccination is an attractive approach for antigen-specific immunotherapy against P. aeruginosa. We explored the feasibility of employing Herpes simplex virus type 1 tegument protein, VP22, as a molecular tool to enhance the immunogen...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2016.07.017
更新日期：2016-08-17 00:00:00
abstract：:There is a growing public health interest in controlling sexually transmitted infections (STIs) through vaccination due to increasing recognition of the global disease burden of STIs and the role of STIs in women's reproductive health, adverse pregnancy outcomes, and the health and well-being of neonates. Neisseria go...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/j.vaccine.2018.02.081
更新日期：2019-11-28 00:00:00
abstract：BACKGROUND:Measles is a highly infectious respiratory disease which causes 122,000 deaths annually. Although measles vaccine is extremely safe and effective, vaccine coverage could be improved by a vaccine that is more easily administered and transported. We developed an inhalable dry powder measles vaccine (MVDP) and ...
journal_title：Vaccine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.vaccine.2014.09.071
更新日期：2014-11-28 00:00:00
abstract：:Mycoplasma hyopneumoniae (M. hyopneumoniae) vaccine strain 168 is an intrapulmonically injected attenuated live vaccine that is available in the Chinese market. The aim of this study was to develop suitable adjuvants for this live vaccine to provide effective protection after intramuscular inoculation. Several adjuvan...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2014.03.071
更新日期：2014-06-05 00:00:00
abstract：:The need to avoid using primates has prompted the replacement of primary monkey kidney cells (PMKC) as a substrate for oral polio vaccine (OPV) production. Here, we report on OPV produced on MRC-5 cells using an industrial process capable of producing over 1 billion doses. All serotypes produced on MRC-5 cells proved ...
journal_title：Vaccine
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/j.vaccine.2005.04.002
更新日期：2005-07-21 00:00:00
abstract：:Modified vaccinia Ankara (MVA) recombinants expressing single or multiple RSV surface proteins (F or G) are promising potential vaccines. We studied humoral and cellular responses induced by MVA-F and MVA-G in mice, comparing them to a formalin inactivated RSV preparation (FI-RSV) known to increase disease severity. M...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2004.05.015
更新日期：2004-11-25 00:00:00
abstract：:Respiratory syncytial virus (RSV) is a major respiratory pathogen responsible for severe pulmonary disease. We have developed a parenterally administered vaccine, BBG2Na, which is currently in a phase III clinical trial. BBG2Na comprises residues 130--230 of RSV-A G protein (G2Na) fused to the BB carrier protein. In t...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(01)00105-0
更新日期：2001-07-16 00:00:00
abstract：BACKGROUND:Serologic response to influenza vaccination declines with age. Few other host factors are known to be associated with serologic response. Our objective was to determine whether obesity and vulnerability independently predicted serologic response to influenza vaccination. METHODS:Adults ≥ 50 years were recru...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2012.03.071
更新日期：2012-06-06 00:00:00
abstract：BACKGROUND:A randomized, double-blind, placebo-controlled multicenter trial was conducted in healthy Chinese infants to assess the efficacy and safety of a pentavalent live human-bovine reassortant rotavirus vaccine (RotaTeq™, RV5) against rotavirus gastroenteritis (RVGE). METHODS:4040 participants aged 6-12weeks were...
journal_title：Vaccine
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.vaccine.2017.08.081
更新日期：2017-10-13 00:00:00
abstract：:Understanding the requirements for protection against pneumococcal carriage and pneumonia will greatly benefit efforts in controlling these diseases. Several antigens, in addition to the polysaccharide capsule, have been implicated in both the virulence and protective immunity against Streptococcus pneumoniae; one of ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2011.12.020
更新日期：2012-02-01 00:00:00
abstract：:The aim of this study was to investigate the kinetics of virus replication and cellular responses in the lungs following infection with Marek's disease virus (MDV) and/or vaccination with herpesvirus of turkey (HVT) via the respiratory route. Chickens vaccinated with HVT and challenged with MDV had a higher accumulati...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2010.06.036
更新日期：2010-08-02 00:00:00
abstract：BACKGROUND:The study was designed to determine the feasibility of implementing routine dTpa vaccination in the maternity ward to new mothers and to assess midwives' attitudes toward pertussis booster vaccination, their perceived susceptibility and severity of pertussis in their patients' communities, the perceived barr...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2011.05.049
更新日期：2011-08-05 00:00:00
abstract：:In order to evaluate a combination of yellow fever and typhoid fever vaccine, we conducted a controlled trial comparing reactogenicity and immunogenicity of Vi polysaccharide (ViPS) vaccine and yellow fever 17D (YF) vaccine after single, simultaneous and combined administration. The combined YF/ViPS vaccine was prepar...
journal_title：Vaccine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0264-410x(94)90267-4
更新日期：1994-05-01 00:00:00
abstract：:A multi-centre, randomised, double-blinded, active-controlled, parallel-group clinical trial was carried out to assess the immunogenicity and safety of NBP608-a newly developed live-attenuated zoster vaccine in Korea-relative to Zostavax® in healthy adults aged 50 years or older. Immune responses to the vaccine were e...
journal_title：Vaccine
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.vaccine.2019.04.046
更新日期：2019-06-12 00:00:00
abstract：BACKGROUND:Reactions to DTwP vaccine are well known and are a matter of great concern, much for the development of next generation combination vaccines. To avoid such reactions which occur from foreign compounds, WHO suggested manufacture of DTwP vaccine using semi-synthetic medium. The phase III trial reported here wa...
journal_title：Vaccine
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.vaccine.2012.07.068
更新日期：2012-09-21 00:00:00
abstract：BACKGROUND:In June 2009 a global influenza pandemic was declared by the World Health Organisation. A vaccination programme against H1N1 influenza was introduced in many countries from September 2009, but there was low uptake in both the general population and health professionals in many, though not all, countries. PU...
journal_title：Vaccine
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.vaccine.2011.06.107
更新日期：2011-09-02 00:00:00
abstract：:Panton-Valentine leukocidin (PVL) is a Staphylococcus aureus toxin associated with skin and soft-tissue infections (SSTIs) and life-threatening necrotizing pneumonia in humans. Recent reports have demonstrated that neutralizing antibody to PVL is not protective against SSTI recurrence, thus raising a controversy about...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2011.04.033
更新日期：2011-06-06 00:00:00
abstract：:Bovine viral diarrhea virus (BVDV) is still one of the most serious pathogens in cattle, meriting the development of improved vaccines. Recently, we developed a new adjuvant consisting of poly[di(sodium carboxylatoethylphenoxy)]-phosphazene (PCEP), either CpG ODN or poly(I:C), and an immune defense regulator (IDR) pep...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2014.10.010
更新日期：2014-11-28 00:00:00
abstract：:Capsular polysaccharides are important virulence factors of Streptococcus pneumoniae. The polysaccharide has been used as a component of vaccines against pneumococcal diseases either as plain polysaccharide or better conjugated to a protein. The last one is the vaccine of choice to target child protection. The immune ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2012.09.047
更新日期：2012-11-19 00:00:00
abstract：:In this study we quantified the transmission of pseudorabies virus (PRV) in well-immunized sow herds in The Netherlands. In three herds, sows were tested for antibodies to gE of PRV every time after they had been transported to another barn (survey A). In 99 other herds, sows were tested simultaneously once or twice y...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/0264-410x(96)00022-9
更新日期：1996-08-01 00:00:00
