A history of Panton-Valentine leukocidin (PVL)-associated infection protects against death in PVL-associated pneumonia.

abstract：:Based on the reactivities of monoclonal antibodies, we previously reported that 25 Japanese encephalitis (JE) virus strains fell into five antigenic groups: Nakayama, Beijing-1, Kamiyama, 691004 and Muar. In the present study, we produced monoclonal antibodies against the Beijing-1 strain and obtained the Beijing-1 gr...

journal_title：Vaccine

authors： Satake Y,Hasegawa H,Yoshida M,Kobayashi Y

更新日期：1994-06-01 00:00:00

abstract：:Pertussis vaccination in pregnancy has been introduced by several national advisory bodies, mostly in industrialized countries, as a means to protect young infants from disease by high titers of maternal antibodies. Most recommendations derive from epidemiological needs, but many knowledge gaps remained after implemen...

journal_title：Vaccine

authors： Leuridan E

更新日期：2017-08-16 00:00:00

abstract：BACKGROUND:In 2017, measles elimination was verified in Bhutan, and the country appears to have sufficiently high vaccination coverage to achieve rubella elimination. However, a measles and rubella serosurvey was conducted to find if any hidden immunity gaps existed that could threaten Bhutan's elimination status. MET...

journal_title：Vaccine

authors： Wangchuk S,Nogareda F,Tshering N,Khandu L,Pelden S,Wannemuehler K,Wangdi S,Wangchuk U,Mulders M,Tamang T,Patel MK

更新日期：2019-10-08 00:00:00

abstract：:In a phase I clinical trial, one hundred healthy young adults were randomized to receive two doses 28 days apart of an inactivated, subvirion vaccine containing 15 or 45microg of influenza A/H5N1 hemagglutinin (HA) by the intramuscular (IM) route, or 3 or 9microg of H5 HA by the intradermal(ID) route. Seventy-seven su...

journal_title：Vaccine

authors： Patel SM,Atmar RL,El Sahly HM,Cate TR,Keitel WA

更新日期：2010-04-09 00:00:00

abstract：:Praziquantel (PZQ), which is used to treat all forms of schistosomiasis, has been shown to induce strong T cell activities and decrease T regulatory cell levels. In our study, we investigated whether PZQ may be used as an adjuvant for a hepatitis B surface antigen (HBsAg) DNA vaccine (pcD-S2) in eliciting strong humor...

journal_title：Vaccine

authors： Zou Q,Zhong Y,Su H,Kang Y,Jin J,Liu Q,Geng S,Zhao G,Wang B

更新日期：2010-02-23 00:00:00

abstract：:Salmonella Enteritidis mutants with deletions in phoP, fliC or phoPfliC were tested for their virulence and their ability to induce parameters of the innate and adaptive immunity in addition to their potential for serological differentiation between vaccinated, non-vaccinated and infected chickens. The double phoPfliC...

journal_title：Vaccine

authors： Methner U,Barrow PA,Berndt A,Rychlik I

更新日期：2011-04-12 00:00:00

abstract：:Pandemic outbreaks of influenza are caused by the emergence of a pathogenic and transmissible virus to which the human population is immunologically naïve. Recent outbreaks of highly pathogenic avian influenza (HPAI) of the H5N1 subtype are of particular concern because of the high mortality rate (60% case fatality ra...

journal_title：Vaccine

authors： Giles BM,Ross TM

更新日期：2011-04-05 00:00:00

abstract：:Aging is accompanied by a decline in immune function which can lead to decreased responses to vaccines. Attenuated recombinant Vibrio cholerae O1 vaccine strain CVD 103-HgR elicits a rapid serum vibriocidal antibody (SVA) response and protects against cholera diarrhea in volunteer challenge studies but has not been st...

journal_title：Vaccine

authors： McCarty JM,Lock MD,Bennett S,Hunt KM,Simon JK,Gurwith M

更新日期：2019-03-07 00:00:00

abstract：:Severe acute respiratory syndrome (SARS) caused by a newly identified coronavirus (SARS-CoV) remains a threat to cause epidemics as evidenced by recent sporadic cases in China. In this communication, we evaluated the efficacy and safety of two SARS vaccine candidates based on the recombinant modified vaccinia Ankara (...

journal_title：Vaccine

authors： Czub M,Weingartl H,Czub S,He R,Cao J

更新日期：2005-03-18 00:00:00

abstract：:The data presented here demonstrate that Salmonella typhi is capable of expressing an acid tolerance response (ATR) and that effective induction of this response (in nutrient-rich medium) occurs at pH 5.0 in anaerobic conditions. The candidate live oral S. typhi vaccine strains made by precise genetic methods and whic...

journal_title：Vaccine

authors： Hone DM,Harris AM,Levine MM

更新日期：1994-08-01 00:00:00

abstract：:Vaccines are urgently needed to elicit immunity to different influenza virus strains. DNA vaccines can elicit partial protective immunity, however their efficacy requires improvement. We assessed the capacity of individual type I IFN multigene family members as subtype transgenes to abrogate influenza virus replicatio...

journal_title：Vaccine

authors： James CM,Abdad MY,Mansfield JP,Jacobsen HK,Vind AR,Stumbles PA,Bartlett EJ

更新日期：2007-02-26 00:00:00

abstract：:Cytology-based screening has reduced cervical cancer mortality in countries able to implement, sustain and financially support organized programs that achieve broad coverage. These ongoing secondary prevention efforts considerably complicate the question of whether vaccination against human papillomavirus (HPV) types ...

journal_title：Vaccine

authors： Kim JJ,Brisson M,Edmunds WJ,Goldie SJ

更新日期：2008-08-19 00:00:00

abstract：:The immunogenicity and protective efficacy of a nucleic acid vaccine encoding the herpes simplex virus type 1 (HSV-1) glycoprotein D (gD) gene under the control of the CMV immediate early gene promoter was examined. Mice immunized three times by intramuscular injection with the vaccine developed an HSV specific IgG bu...

journal_title：Vaccine

authors： Bourne N,Milligan GN,Schleiss MR,Bernstein DI,Stanberry LR

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND:Ebola viral disease (EVD) epidemic need to be contained through means which include vaccination of susceptible population. Vaccination has eradicated major killer diseases. OBJECTIVE:The study determined the health workers willingness to participate in EVD vaccine clinical trials and receive EVD vaccine. M...

journal_title：Vaccine

authors： Olowookere SA,Abioye-Kuteyi EA,Adekanle O

更新日期：2016-11-11 00:00:00

abstract：:Salmonella is one of the key global causes of food and water borne enteric infections, responsible for significant morbidity and mortality worldwide especially in developing countries. Currently available vaccines against typhoid are moderately effective with several side effects and not efficacious against all Salmon...

journal_title：Vaccine

authors： Verma S,Sugadev R,Kumar A,Chandna S,Ganju L,Bansal A

更新日期：2018-06-27 00:00:00

abstract：:In 2004, we conducted a study in Piemonte (Italy), in order to describe incidence, treatment, hospitalizations and costs of herpes zoster (HZ), in population over 14 years of age. Twenty-four regional general practitioners, with 26,394 patients >14 years in charge (0.71% of the regional population), reported prospecti...

journal_title：Vaccine

authors： Di Legami V,Gianino MM,Ciofi degli Atti M,Massari M,Migliardi A,Tomba GS,Zotti C,Zoster Study Group.

更新日期：2007-10-23 00:00:00

abstract：:A modified GnRH peptide (CHWSYGLRPG-NH2) was conjugated to tetanus toxoid and formulated with different adjuvants (non-ionic surfactant vesicles, aluminium hydroxide, Quil A, PLGA (poly(lactide-co-glycolide)/triacetin), and Quil A/PLGA). A comparison of the anti-fertility efficacy of the formulations was made by exami...

journal_title：Vaccine

authors： Ferro VA,Costa R,Carter KC,Harvey MJ,Waterston MM,Mullen AB,Matschke C,Mann JF,Colston A,Stimson WH

更新日期：2004-02-25 00:00:00

abstract：:Smallpox eradication is considered to be one of the most remarkable accomplishments of the 20th century. Lessons learned from the campaign during the 1960s and 1970s in the Democratic Republic of Congo (DRC) can provide important information for the development of other eradication programs including polio. The DRC is...

journal_title：Vaccine

authors： Muyembe-Tamfum JJ,Mulembakani P,Lekie RB,Szczeniowski M,Ježek Z,Doshi R,Hoff N,Rimoin AW

更新日期：2011-12-30 00:00:00

abstract：:The use of viral vectors in heterologous prime-boost regimens to induce potent T cell responses in addition to humoral immunity is a promising vaccination strategy in the fight against malaria. We conducted an open-label, first-in-human, controlled Phase I study evaluating the safety and immunogenicity of Matrix-M adj...

journal_title：Vaccine

authors： Venkatraman N,Anagnostou N,Bliss C,Bowyer G,Wright D,Lövgren-Bengtsson K,Roberts R,Poulton I,Lawrie A,Ewer K,V S Hill A

更新日期：2017-10-27 00:00:00

abstract：:The full-length ecdysone receptor cDNA of Choristoneura fumiferana (CfEcR-B) was cloned into bacterial expression systems and the recombinant protein was expressed either with a His-tag (His-EcR-B) or glutathione-S-transferase (GST) fusion (GST-EcR-B). The His-EcR-B was expressed mostly as insoluble aggregates, while ...

journal_title：Vaccine

authors： Yang DH,Makhmoudova A,Arif BM,Feng Q,Retnakaran A,Palli SR,Krell PJ

更新日期：2006-04-12 00:00:00

abstract：:Mucosal immunization with a killed whole-cell pneumococcal vaccine, given with enterotoxin-related adjuvants, has been shown to confer multi-serotype protection against colonization of the nasopharynx and middle ear in mice. However, because novel mucosal immunization strategies may be difficult to implement, here we ...

journal_title：Vaccine

authors： Lu YJ,Leite L,Gonçalves VM,Dias Wde O,Liberman C,Fratelli F,Alderson M,Tate A,Maisonneuve JF,Robertson G,Graca R,Sayeed S,Thompson CM,Anderson P,Malley R

更新日期：2010-11-03 00:00:00

abstract：:In chronic Hepatitis B Virus (HBV) infection the function of dendritic cells (DC), T- and B-cells is impaired. DC vaccination is an option to overcome this. DC pulsed in vitro with HBV sub viral particles (HBVsvp) and used to immunize mice can activate HBV directed humoral and cellular immune responses. In the present...

journal_title：Vaccine

authors： Farag MM,Tedjokusumo R,Flechtenmacher C,Asen T,Stremmel W,Müller M,Protzer U,Weigand K

更新日期：2012-09-14 00:00:00

abstract：:Activation of the innate immune system by different homotopes may direct the subsequent specific immune response, and as a consequence may have significant implications on vaccination. In this study, effects of i.v. administered lipopolysaccharide (LPS), and lipoteichoic acid (LTA), respectively, and s.c. administered...

journal_title：Vaccine

authors： Maldonado LM,Lammers A,Nieuwland MG,De Vries Reilingh G,Parmentier HK

更新日期：2005-04-15 00:00:00

abstract：:Vaccines that could protect humans against the highly lethal Marburg and Ebola viruses have eluded scientists for decades. Classical approaches have been generally unsuccessful for Marburg and Ebola viruses and pose enormous safety concerns as well. Modern approaches, in particular those using vector-based approaches ...

journal_title：Vaccine

authors： Reed DS,Mohamadzadeh M

更新日期：2007-03-01 00:00:00

abstract：:This report provides an overview of methods used to conduct systematic reviews for the US Food and Drug Administration (FDA) Mini-Sentinel project, which is designed to inform the development of safety monitoring tools for FDA-regulated products including vaccines. The objective of these reviews was to summarize the l...

journal_title：Vaccine

authors： McPheeters ML,Sathe NA,Jerome RN,Carnahan RM

更新日期：2013-12-30 00:00:00

abstract：:Infection of rubella virus at the early stages of pregnancy in women who are not immune to rubella often induces congenital anomalies in infants, namely congenital rubella syndrome (CRS). This paper is the first comprehensive report of CRS cases in Japan, compiled from a questionnaire to major hospitals, reports to jo...

journal_title：Vaccine

authors： Katow S

更新日期：2004-09-28 00:00:00

abstract：:To evaluate the safety and immunogenicity of a diphtheria, tetanus, acellular pertussis and Haemophilus infuenzae Type b (DTaP/Hib) combination vaccine first developed by a Chinese manufacturer, a randomized, two-stage, parallel controlled, single center clinical trial was conducted in Dafeng, Jiangsu Province of Chin...

journal_title：Vaccine

authors： Li G,Zhang H,Zhou W,Ye Q,Li F,Wang H,Hou Q,Xu Y,Ma X,Tan Y,Wang L,Li Y,Li H,Meng F,Liang Q,Liu A,Qin C,Wei W,Liu J,Ruan C,Tao W,Zhang S,Zheng H,Zhu F

更新日期：2010-06-07 00:00:00

abstract：:Recombinant hepatitis B surface antigen (HBsAg) particles derived from Chinese hamster ovary (CHO) cells were stored at various conditions for 12-18 months in their naked form or adsorbed to alum (HBV vaccine). The physical, chemical and immunological parameters during storage at -20 degrees C, 4 degrees C, room tempe...

journal_title：Vaccine

authors： Diminsky D,Moav N,Gorecki M,Barenholz Y

更新日期：1999-08-20 00:00:00

abstract：:Toll-like receptors 7 (TLR7) and 8 (TLR8) recognize viral single-stranded RNA and small molecular weight agonists to activate anti-viral immune responses. TLR8s from different species have distinct ligand recognitions. For example, human TLR8 is responsive to ligand stimulation, but mouse and rat TLR8 are activated by...

journal_title：Vaccine

authors： Lai CY,Liu YL,Yu GY,Maa MC,Leu TH,Xu C,Luo Y,Xiang R,Chuang TH

更新日期：2014-09-29 00:00:00

abstract：:The Czech Republic, Denmark, Finland, Norway, the Netherlands, Slovakia, Sweden and the UK all have very low HBsAg carrier rates; in the Scandinavian countries, for instance, carrier rates are on the order of 0.05%. Most countries in this group are unconvinced that the carrier rates and the burden of disease caused by...

journal_title：Vaccine

authors： Iwarson S

更新日期：1998-11-01 00:00:00