Abstract：
:Vaccines are urgently needed to elicit immunity to different influenza virus strains. DNA vaccines can elicit partial protective immunity, however their efficacy requires improvement. We assessed the capacity of individual type I IFN multigene family members as subtype transgenes to abrogate influenza virus replication in a vaccination/challenge mouse model. Differences in antiviral efficacy were found among the subtypes with IFNA5 and IFNA6 being most effective, while IFNA1 was the least effective in reducing lung virus replication. Mice vaccinated with combinatorial HA/IFNA6 or NP/IFNA6 showed reduced lung viral titres, clinical score, body weight loss, and pulmonary tissue damage compared to IFNA6, HA, or NP viral vaccination alone. In addition, IFNA6 increased IgG2a titres with upregulation of IFN-gamma response in the respiratory tract. We conclude that IFN-alpha 6 has antiviral and immunomodulatory effects, which improve efficacy of DNA vaccines for enhanced control of influenza.
journal_name
Vaccinejournal_title
Vaccineauthors
James CM,Abdad MY,Mansfield JP,Jacobsen HK,Vind AR,Stumbles PA,Bartlett EJdoi
10.1016/j.vaccine.2006.10.038subject
Has Abstractpub_date
2007-02-26 00:00:00pages
1856-67issue
10eissn
0264-410Xissn
1873-2518pii
S0264-410X(06)01151-0journal_volume
25pub_type
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