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Expression of human antibodies in eukaryotic micro-algae.

Abstract：

:Protein based therapeutics have enjoyed great success over the past decade. Unfortunately, with this clinical success comes a heavy price tag, owing to the inherently high costs of capitalization and production using mammalian cell fermentation. To address this problem, we have begun developing a system for the expression of recombinant proteins in the unicellular eukaryotic green algae, Chlamydomonas reinhardtii, leading to the production of human IgA single chain antibodies. The expression of human monoclonal antibodies in C. reinhardtii offers an attractive alternative to traditional mammalian based expression systems for several reasons, including an ability to rapidly obtain stable plastid and nuclear transformants, coupled with inherently low costs of capitalization and production.

journal_name

Vaccine

journal_title

Vaccine

authors

Mayfield SP,Franklin SE

doi

10.1016/j.vaccine.2004.11.013

subject

Has Abstract

pub_date

2005-03-07 00:00:00

pages

1828-32

issue

15

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(04)00837-0

journal_volume

23

pub_type

杂志文章,评审

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