Epitope specificities of broadly neutralizing plasmas from HIV-1 infected subjects.

abstract：:Mice inoculated intranasally (i.n.) with a recombinant strain of live Lactococcus lactis expressing tetanus toxin fragment C (TTFC), produced both serum and secretory antibodies to TTFC. Killed bacteria which had accumulated TTFC intracellularly in vitro also elicited protective serum antibody responses. There was no ...

journal_title：Vaccine

authors： Norton PM,Wells JM,Brown HW,Macpherson AM,Le Page RW

更新日期：1997-04-01 00:00:00

abstract：:Malignant catarrhal fever (MCF) is a fatal lymphoproliferative disease of cattle that, in East Africa, results from transmission of the causative virus, alcelaphine herpesvirus 1 (AlHV-1), from wildebeest. A vaccine field trial involving an attenuated AlHV-1 virus vaccine was performed over two wildebeest calving seas...

journal_title：Vaccine

authors： Lankester F,Russell GC,Lugelo A,Ndabigaye A,Mnyambwa N,Keyyu J,Kazwala R,Grant D,Percival A,Deane D,Haig DM,Cleaveland S

更新日期：2016-02-03 00:00:00

abstract：:In 2005, in accordance with recommendations made by the European Medicines Agency, the Italian Drug Agency ordered withdrawal of the hexavalent Hexavac(®) vaccine (Sanofi Pasteur MSD) from the market. Concerns had been raised about the low immunogenicity of the hepatitis B virus component of the vaccine, assessed by m...

journal_title：Vaccine

authors： Carollo M,Palazzo R,Bianco M,Pandolfi E,Chionne P,Fedele G,Tozzi AE,Carsetti R,Romanò L,Ausiello CM

更新日期：2013-01-07 00:00:00

abstract：:General vaccination with the 7-valent pneumococcal conjugate vaccine was recommended in Germany in July 2006 for all children <2 years. The proportion of reported invasive pneumococcal disease (IPD) caused by vaccine serotypes before vaccine introduction was considerably lower than in the US. We report data from natio...

journal_title：Vaccine

authors： Rückinger S,van der Linden M,Reinert RR,von Kries R,Burckhardt F,Siedler A

更新日期：2009-06-24 00:00:00

abstract：:SPf66 is the first chemically synthesised vaccine to elicit a partial protective immune response against malaria. The aluminium hydroxide (alum)-adsorbed SPf66 vaccine is weakly immunogenic and of poor to moderate efficacy in humans. To investigate the possibility of improving SPf66 vaccine immunogenicity, a delivery ...

journal_title：Vaccine

authors： Rosas JE,Hernández RM,Gascón AR,Igartua M,Guzman F,Patarroyo ME,Pedraz JL

更新日期：2001-08-14 00:00:00

abstract：:Aluminum based adjuvants (alum), including aluminum hydroxide (Alhydrogel) and aluminum phosphate are the most commonly used adjuvant in the US. In order to ensure quality of vaccines, regulatory authorities require evaluation of antigen content in final vaccine products. Currently, there are no generic methods availa...

journal_title：Vaccine

authors： Zhu D,Saul A,Huang S,Martin LB,Miller LH,Rausch KM

更新日期：2009-10-09 00:00:00

abstract：:Influenza becomes epidemic worldwide every year, and many individuals receive vaccination annually. Quality control relating to safety and potency of influenza vaccines is important to maintain public confidence. The safety of influenza vaccines has been assessed by clinical trials, and animal safety tests are perform...

journal_title：Vaccine

authors： Momose H,Sasaki E,Kuramitsu M,Hamaguchi I,Mizukami T

更新日期：2018-10-15 00:00:00

abstract：:Eight different vaccination schemes using four commercially available inactivated Bluetongue vaccines against serotypes 4 and 8 in three different combinations (setting 1-3) were tested under field conditions for their ability to generate a measurable immune response in sheep. Animals of setting 1 (groups A-D) were si...

journal_title：Vaccine

authors： Hilke J,Strobel H,Woelke S,Stoeter M,Voigt K,Grimm L,Meilwes J,Punsmann T,Blaha I,Salditt A,Rohn K,Bastian M,Ganter M

更新日期：2019-09-16 00:00:00

abstract：:Interest in addressing antimicrobial resistance (AMR) has grown recently but little effort has been made to consider how existing and new vaccines could impact on AMR. A 2017 Chatham House meeting considered the role of vaccines and how to demonstrate their value through their impact on AMR. Ways existing vaccines hav...

journal_title：Vaccine

authors： Clift C,Salisbury DM

更新日期：2017-12-04 00:00:00

abstract：:Safety and efficacy of adjuvanted vaccines in autoimmune individuals raises growing clinical and scientific interest. Protection from influenza would bring particular benefits in these patients with common cardiac and respiratory impairment. This study evaluates efficacy, clinical safety and immune effects of the admi...

journal_title：Vaccine

authors： Setti M,Fenoglio D,Ansaldi F,Filaci G,Bacilieri S,Sticchi L,Ferrera A,Indiveri F,Ghio M

更新日期：2009-05-26 00:00:00

abstract：:Mumps virus (MuV) causes acute infection in humans with characteristic swelling of the parotid gland. While vaccination has greatly reduced the incidence of MuV infection, there have been multiple large outbreaks of mumps virus (MuV) in highly vaccinated populations. The most common vaccine strain, Jeryl Lynn, belongs...

journal_title：Vaccine

authors： Zengel J,Phan SI,Pickar A,Xu P,He B

更新日期：2017-07-13 00:00:00

abstract：:Binding of antibodies to oligomeric envelope glycoprotein of R5-tropic primary isolates of human immunodeficiency virus type 1 (HIV-1) was studied by flow cytometry using sera from HIV-1 vaccine recipients and clade B and C HIV-1-infected patients, and monoclonal and polyclonal antibodies to neutralizing epitopes of H...

journal_title：Vaccine

authors： Gorse GJ,Patel GB,Arbuckle JA,Belshe RB

更新日期：2004-01-02 00:00:00

abstract：:Feline immunodeficiency virus (FIV) is a natural lentiviral pathogen of cats which can be experimentally transmitted via rectal and vaginal routes--the major routes of human immunodeficiency virus type 1 transmission in man. An important objective for lentiviral research is the development of vaccine strategies which ...

journal_title：Vaccine

authors： Finerty S,Stokes CR,Gruffydd-Jones TJ,Hillman TJ,Reeves NA,Whiting CV,Schaaper WM,Dalsgaard K,Harbour DA

更新日期：2000-08-01 00:00:00

abstract：BACKGROUND:IXIARO® is a Vero cell-derived, inactivated Japanese encephalitis (JE) vaccine licensed mainly in western countries for children and adults traveling to JE endemic areas. Limited immunogenicity and safety data in elderly travelers have been available. OBJECTIVES:To evaluate safety and immunogenicity of IXIA...

journal_title：Vaccine

authors： Cramer JP,Dubischar K,Eder S,Burchard GD,Jelinek T,Jilma B,Kollaritsch H,Reisinger E,Westritschnig K

更新日期：2016-08-31 00:00:00

abstract：:In future, a policy of "vaccinate-to-live" may be included in the repertoire of foot-and-mouth disease (FMD) control measures and in support of this approach, we have investigated the hypothesis that vaccine-induced reduction in virus replication and excretion from pigs can be correlated to the severity of clinical si...

journal_title：Vaccine

authors： Parida S,Fleming L,Oh Y,Mahapatra M,Hamblin P,Gloster J,Doel C,Gubbins S,Paton DJ

更新日期：2007-11-07 00:00:00

abstract：BACKGROUND:This phase I trial evaluated the safety and immunogenicity of a candidate tuberculosis vaccination regimen, ChAdOx1 85A prime-MVA85A boost, previously demonstrated to be protective in animal studies, in healthy UK adults. METHODS:We enrolled 42 healthy, BCG-vaccinated adults into 4 groups: low dose Starter ...

journal_title：Vaccine

authors： Wilkie M,Satti I,Minhinnick A,Harris S,Riste M,Ramon RL,Sheehan S,Thomas ZM,Wright D,Stockdale L,Hamidi A,O'Shea MK,Dwivedi K,Behrens HM,Davenne T,Morton J,Vermaak S,Lawrie A,Moss P,McShane H

更新日期：2020-01-22 00:00:00

abstract：:Universal infant vaccination with the 7-valent pneumococcal conjugate vaccine (PCV7) has nearly eliminated PCV7-serotype invasive pneumococcal disease (IPD) in young U.S. children, but has been accompanied by increases in the incidence of serotype 19A IPD. Because antibiotic-non-susceptible 19A has increased more than...

journal_title：Vaccine

authors： Van Effelterre T,Moore MR,Fierens F,Whitney CG,White L,Pelton SI,Hausdorff WP

更新日期：2010-05-07 00:00:00

abstract：:Vaccination is the best available measure of limiting the impact of the next influenza pandemic. Ideally, a candidate pandemic influenza vaccine should be easy to administer and should elicit strong mucosal and systemic immune responses. Production of influenza subunit antigen in transient plant expression systems is ...

journal_title：Vaccine

authors： Madhun AS,Haaheim LR,Nøstbakken JK,Ebensen T,Chichester J,Yusibov V,Guzman CA,Cox RJ

更新日期：2011-07-12 00:00:00

abstract：BACKGROUND:RTS,S/AS01 is a safe and moderately efficacious vaccine considered for implementation in endemic Africa. Model predictions of impact and cost-effectiveness of this new intervention could aid in country adoption decisions. METHODS:The impact of RTS,S was assessed in 43 countries using an ensemble of models o...

journal_title：Vaccine

authors： Galactionova K,Tediosi F,Camponovo F,Smith TA,Gething PW,Penny MA

更新日期：2017-01-03 00:00:00

abstract：:In order to evaluate in humans the safety and immunogenicity of a Pseudomonas aeruginosa vaccine composed of outer membrane proteins (OMPs), CFC-101, we carried out a phase I/IIa clinical trial in healthy male volunteers. Groups of six volunteers were immunized either subcutaneously (s.c.) or intramuscularly (i.m.) wi...

journal_title：Vaccine

authors： Jang IJ,Kim IS,Park WJ,Yoo KS,Yim DS,Kim HK,Shin SG,Chang WH,Lee NG,Jung SB,Ahn DH,Cho YJ,Ahn BY,Lee Y,Kim YG,Nam SW,Kim HS

更新日期：1999-01-01 00:00:00

abstract：:A method was developed for cultivation of the strain Shigella flexneri 2a 77 with two attenuated markers. It ensures the preservation of the initial properties of the strain. The regimen for control of dissolved oxygen level was optimized. It was established that yeast extract is a necessary component of the nutritive...

journal_title：Vaccine

authors： Nenkov P,Bratoeva M,Vitanov T,Marinova S,Denchev V,Linde K

更新日期：1987-09-01 00:00:00

abstract：:In HIV vaccine trials, the collection and analysis of participant behavior data associated with risk of acquiring HIV-infection is important for a number of reasons. Although the rationale for behavioral risk assessment in HIV vaccine clinical trials is clear, consistent collection of behavioral data over time and acr...

journal_title：Vaccine

authors： Andrasik MP,Karuna ST,Nebergall M,Koblin BA,Kublin JG,NIAID HIV Vaccine Trials Network.

更新日期：2013-09-13 00:00:00

abstract：:This study evaluated the attenuated Salmonella Enteritidis (SE) ghost strain JOL2114 (Δlon ΔcpxR Δasd), which displays on the bacterial surface the H1N1 hemagglutinin globular head portion (HA1; amino acid residues 63-286) on the bacterial surface for protective efficacy against Salmonella and H1N1 challenge in the ch...

journal_title：Vaccine

authors： Won G,Senevirathne A,Lee JH

更新日期：2020-06-09 00:00:00

abstract：:Since 2005, the Government of the United States of America has provided more than US$ 50 million to advance influenza vaccine development in low-resourced countries. This programme has provided a unique opportunity for the US Government to develop a comprehensive view of, and to understand better the challenges and fu...

journal_title：Vaccine

authors： Perdue ML,Bright RA

更新日期：2011-07-01 00:00:00

abstract：OBJECTIVE:To evaluate the effectiveness of seasonal influenza vaccine in preventing Emergency Department (ED) visits and hospitalisations for influenza like illness (ILI) in children. METHODS:We conducted a test negative case-control study during the 2011-2012 and 2012-2013 influenza seasons. Eleven paediatric hospita...

journal_title：Vaccine

authors： Menniti-Ippolito F,Da Cas R,Traversa G,Santuccio C,Felicetti P,Tartaglia L,Trotta F,Di Pietro P,Barabino P,Renna S,Riceputi L,Tovo PA,Gabiano C,Urbino A,Baroero L,Le Serre D,Virano S,Perilongo G,Daverio M,Gnoato E,

更新日期：2014-07-31 00:00:00

abstract：:A new strategy for designing synthetic vaccines is presented. In this approach synthetic peptides are conformationally restricted by replacing putative hydrogen bonds with covalent mimics. The chemistry for substituting a hydrazone-ethane link (N-N = CH-CH2-CH2) for an (i + 4)----i hydrogen bond in a pentapeptide with...

journal_title：Vaccine

authors： Satterthwait AC,Arrhenius T,Hagopian RA,Zavala F,Nussenzweig V,Lerner RA

更新日期：1988-04-01 00:00:00

abstract：OBJECTIVE:Pneumococcal disease is a significant problem in immunocompromised persons, particularly in HIV-infected individuals. The CDC recently updated pneumococcal vaccination recommendations for immunocompromised adults, adding the 13-valent pneumococcal conjugate vaccine (PCV13) to the previously recommended 23-val...

journal_title：Vaccine

authors： Smith KJ,Nowalk MP,Raymund M,Zimmerman RK

更新日期：2013-08-20 00:00:00

abstract：:Clinical and serum antibody responses following intramuscular injection of two formulations of Salmonella typhi Vi capsular polysaccharide (Vi) were assessed in a double-blind evaluation. Healthy adults were randomly assigned to receive a 25 micrograms dose of liquid (Vi-Liq; n = 182) or freeze-dried Vi vaccine (Vi-Ly...

journal_title：Vaccine

authors： Keitel WA,Bond NL,Zahradnik JM,Cramton TA,Robbins JB

更新日期：1994-01-01 00:00:00

abstract：:The 2-1-1 rabies postexposure treatment schedule is an abbreviated regimen in which a tissue culture rabies vaccine is administered intramuscularly at two sites on day 0, and at one site on days 7 and 21. Compared to the standard five-dose intramuscular regimen, the 2-1-1 schedule reduces the number of clinic visits f...

journal_title：Vaccine

authors： Chutivongse S,Wilde H,Fishbein DB,Baer GM,Hemachudha T

更新日期：1991-08-01 00:00:00

abstract：INTRODUCTION:Streptococcus pneumoniae is a capsulated bacterium that can cause severe infection in patients with thalassemia major, particularly those who have undergone splenectomy. The absence of the spleen as well as zinc deficiency in splenectomized patients with thalassemia major increases the possibility of devel...

journal_title：Vaccine

authors： Sari TT,Akib AAP,Gatot D,Roswita Harahap A,Bardosono S,Hadinegoro SRS

更新日期：2017-08-16 00:00:00