Abstract：
:Since the introduction to the Swiss market in 1997, Crucell (former Berna Biotech Ltd.), has sold over 41 million doses worldwide of the virosomal adjuvanted influenza vaccine, Inflexal V. Since 1992, 29 company sponsored clinical studies investigating the efficacy and safety of Inflexal V have been completed in which 3920 subjects participated. During its decade on the market, Inflexal V has shown an excellent tolerability profile due to its biocompatibility and purity. The vaccine contains no thiomersal or formaldehyde and its purity is reflected in the low ovalbumin content. By mimicking natural infection, the vaccine is highly efficacious. Inflexal V is the only adjuvanted influenza vaccine licensed for all age groups and shows a good immunogenicity in both healthy and immunocompromised elderly, adults and children. This review presents and discusses the experience with Inflexal V during the past decade.
journal_name
Vaccinejournal_title
Vaccineauthors
Herzog C,Hartmann K,Künzi V,Kürsteiner O,Mischler R,Lazar H,Glück Rdoi
10.1016/j.vaccine.2009.05.029subject
Has Abstractpub_date
2009-07-16 00:00:00pages
4381-7issue
33eissn
0264-410Xissn
1873-2518pii
S0264-410X(09)00706-3journal_volume
27pub_type
杂志文章,评审相关文献
VACCINE文献大全abstract：INTRODUCTION:Hepatitis B is a major preventable cause of morbidity and mortality from chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. We aimed to evaluate the performance and outcomes of the Korean Perinatal Hepatitis B Prevention Programme (PHBPP) and to investigate the impact of the current post-exp...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2020.05.044
更新日期：2020-07-22 00:00:00
abstract：BACKGROUND:A recent mumps outbreak in Israel despite an ongoing national program of a 2-dose universal childhood vaccination policy since 1988, raised questions regarding population immunity among young adults. OBJECTIVE:To assess the seroprevalence of mumps antibodies among young Israeli adults born after 1987 in ord...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2011.01.103
更新日期：2011-03-24 00:00:00
abstract：:Even though schistosomicidal agents and other control measures, including public hygiene and snail control exist, development of an efficacious vaccine still remains the most potentially powerful method for control of schistosomiasis. In our continuing efforts to develop a vaccine against schistosomiasis, we have sele...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2004.09.018
更新日期：2005-02-10 00:00:00
abstract：BACKGROUND:Vaccination against Haemophilus influenzae type b (Hib) is included in routine pediatric immunization schedule in the United States. Previous vaccine shortages have created the need for additional options for Hib vaccination. METHODS:This phase III, randomized, multi-centered study (NCT01000974) evaluated t...
journal_title：Vaccine
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.vaccine.2017.05.018
更新日期：2017-06-16 00:00:00
abstract：:Ten prospective clinical trials conducted in elderly and high-risk adults have failed to show that pneumococcal vaccine prevents pneumococcal bacteraemia and all pneumonia. Several of these trials focused on unrepresentative populations and most had serious methodological problems. Few adequately considered sample siz...
journal_title：Vaccine
pub_type： 杂志文章,meta分析
doi：10.1016/j.vaccine.2003.09.027
更新日期：2004-02-25 00:00:00
abstract：:Human botulism is commonly associated with botulinum neurotoxin (BoNT) serotypes A, B, E and F. This suggests that the greatest need is for a tetravalent vaccine that provides protection against all four of these serotypes. In current study, we investigated the feasibility of generating several tetravalent vaccines th...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2013.03.046
更新日期：2013-05-07 00:00:00
abstract：:Taking the results of a prospective cohort study by our group that evaluated the effectiveness of the inactivated subunit virosomal influenza vaccine (Inflexal V), Crucell-Berna) in the prevention of influenza-related diseases and the reduction of its negative economic consequences, the economic costs and benefits for...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2009.01.053
更新日期：2009-05-26 00:00:00
abstract：:Research into active immunisation against gonadotrophin releasing hormone (GnRH-I) has gained widespread acceptance as a means of controlling reproduction and behaviour of farm, companion and wild animals. Many studies describe the use of multiple copies of the self-peptide in linear alignment and conjugation with a l...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2007.12.052
更新日期：2008-03-04 00:00:00
abstract：:Prevalence of non-typeable Haemophilus influenzae (NTHi) in the etiology of invasive infections in immunocompromised individuals is increasing. Serum IgG antibody levels to H. influenzae protein D (PD) were significantly lower in adults suffering from chronic conditions causing secondary immunodeficiency (COPD, cancer...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2011.12.113
更新日期：2012-02-08 00:00:00
abstract：:In anticipation of future combination vaccines, a recombinant class 3 porin (rPorB) of group B meningococci was evaluated as an alternative carrier protein for a Haemophilus influenzae type b (Hib) polyribosylribotol phosphate (PRP) conjugate vaccine. The use of rPorB may avoid undesirable immunologic interactions amo...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(98)00174-1
更新日期：1998-11-01 00:00:00
abstract：PURPOSE:Meningococcal C conjugate vaccine was included in December 2000 in the Spanish childhood vaccination at 2, 4 and 6 months of age. In 2006, routine vaccination was modified to two doses at 2 and 4-6 months and a booster dose during the second year of age. Additionally, successive catch-up campaigns were launched...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2014.03.010
更新日期：2014-05-07 00:00:00
abstract：:In some serotypes of adenovirus (Ad), the penton base and attached trimeric fiber assemble into dodecameric virus-like particles called penton-dodecahedron (Pt-Dd), which can be internalized and used to deliver the vaccine antigens and drugs. Fowl adenovirus serotype 4 (FAdV-4) is an important pathogen, causing seriou...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2018.12.041
更新日期：2019-02-04 00:00:00
abstract：:Aging is accompanied by a decline in immune function which can lead to decreased responses to vaccines. Attenuated recombinant Vibrio cholerae O1 vaccine strain CVD 103-HgR elicits a rapid serum vibriocidal antibody (SVA) response and protects against cholera diarrhea in volunteer challenge studies but has not been st...
journal_title：Vaccine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.vaccine.2019.01.077
更新日期：2019-03-07 00:00:00
abstract：:Plague, which is initiated by Yersinia pestis infection, is a fatal disease that progresses rapidly and leads to high mortality rates if not treated. Antibiotics are an effective plague therapy, but antibiotic-resistant Y. pestis strains have been reported and therefore alternative countermeasures are needed. In the p...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2011.07.059
更新日期：2011-09-16 00:00:00
abstract：:Passive immunization of mice with a monoclonal IgE antibody to Schistosoma japonicum (SJ18 epsilon. 1) induces significant protection to a challenge infection and the target molecule of SJ18 epsilon. 1 is paramyosin. In the present study, we demonstrate the B cell epitope of paramyosin recognized by SJ18 epsilon. 1 by...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(96)00100-4
更新日期：1997-01-01 00:00:00
abstract：:Yellow fever is an acute infectious disease caused by prototype virus of the genus Flavivirus. It is endemic in Africa and South America where it represents a serious public health problem causing epidemics of hemorrhagic fever with mortality rates ranging from 20% to 50%. There is no available antiviral therapy and v...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2015.03.077
更新日期：2015-08-20 00:00:00
abstract：:Influenza is a significant cause of morbidity and mortality worldwide, and the World Health Organization highly recommends maternal vaccination during pregnancy. The indirect effect of maternal vaccination on other close contacts other than newborns is unknown. To evaluate this, we conducted a nested substudy between ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2020.08.014
更新日期：2020-10-07 00:00:00
abstract：:Pertactin/P.69, a surface-associated polypeptide antigen of Bordetella pertussis, was expressed in a Salmonella typhimurium aroA aroD vaccine strain, BRD509, using different expression systems, and the immune response in mice against these constructs was compared. Initially, Pertactin/P.69 was expressed on the surface...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(96)00036-9
更新日期：1996-10-01 00:00:00
abstract：:Type I IFN and IL-12 are well documented to serve as so called "signal 3" cytokines, capable of facilitating CD8(+) T cell proliferation, effector function and memory formation. While their ability to serve in this capacity is well established, to date, no non-cytokine signal 3 mediators have been clearly identified. ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2011.12.017
更新日期：2012-02-01 00:00:00
abstract：:Outer membrane protein (OMP) vaccines are being developed against Neisseria meningitidis serogroup B which may provide protection against common circulating serotypes and serosubtypes in some countries. However, limited data is available in Europe from genosubtyping meningococci. We therefore undertook a retrospective...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(03)00033-1
更新日期：2003-06-02 00:00:00
abstract：:The aim of this study was to determine the rubella seroprevalence in women of reproductive age. This cross-sectional study was conducted on women aged 15-49 years. Serologic studies were performed by using the ELISA method. The number of women enrolled in the study was 607, the mean age was 30.7+/-9.3 years and 13.2% ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2006.09.033
更新日期：2007-01-15 00:00:00
abstract：OBJECTIVE:We related seroprevalence and outbreaks data in order to identify factors that could explain the occurrence of outbreaks despite high vaccination coverage in Medellín Colombia. METHODS:Samples from a population seroprevalence data obtained in 2009 in a random survey were analyzed. IgG levels were determined ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2015.08.088
更新日期：2015-10-13 00:00:00
abstract：OBJECTIVES:To identify predictors of: uptake of the childhood influenza vaccine in the 2015-2016 influenza season, parental perceptions of side-effects from the influenza vaccine and intention to vaccinate one's child for influenza in the 2016-2017 influenza season. DESIGN:Cross-sectional online survey. SETTING:Data ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2017.02.031
更新日期：2017-04-04 00:00:00
abstract：:At present, the seed viruses for the manufacture of licensed seasonal inactivated influenza vaccines in the United States are derived from primary egg isolates as a result of concerns associated with adventitious agents. According to the prevailing view, the passage of influenza viruses through eggs serves as a filter...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2011.02.041
更新日期：2011-04-12 00:00:00
abstract：:Dengue virus (DENV) is the causal agent of severe disease and, in some cases, mortality in humans, but no licensed vaccines against dengue are available. An effective vaccine against dengue requires long-term humoral and cellular immune responses. Several viral proteins have been the subjects of intense research, espe...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2013.03.009
更新日期：2013-05-01 00:00:00
abstract：PURPOSE:We tested the hypotheses that consistency and strength of clinician recommendation of the human papillomavirus (HPV) vaccination would be associated with vaccine delivery rates. METHODS:From October 2015 through January 2016, we conducted a survey of primary care clinicians (n=227) in Southeastern Minnesota to...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2017.09.056
更新日期：2017-10-27 00:00:00
abstract：:The feasibility of developing a prophylactic vaccine against SARS was assessed by comparing the immune responses elicited by immunizing mice with a recombinant SARS spike glycoprotein (S-protein) formulated with different adjuvants, given by different routes. In both young and aged mice, an intranasal Protollin-formul...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2007.06.017
更新日期：2007-08-21 00:00:00
abstract：:An experimental infection with classical swine fever (CSF) virus in E2 sub-unit marker vaccine vaccinated gilts was conducted in order to evaluate the effect of vaccination on virus transmission and course of the disease. Therefore, clinical signs as well as horizontal and vertical virus transmission were monitored in...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(01)00320-6
更新日期：2001-10-12 00:00:00
abstract：:The presence of resident Langerhans cells (LCs) in the epidermis makes the skin an attractive target for DNA vaccination. However, reliable animal models for cutaneous vaccination studies are limited. We demonstrate an ex vivo human skin model for cutaneous DNA vaccination which can potentially bridge the gap between ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2009.07.088
更新日期：2009-10-09 00:00:00
abstract：PURPOSE:Vaccines recommended for adolescents are considered safe and effective, however administration may occasionally result in acute pain at the injection site or syncope (fainting). These adverse effects pose a risk to patient safety and are potential barriers to adherence to future vaccinations. We assessed a nove...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2018.05.070
更新日期：2018-06-22 00:00:00
