Abstract：
:The feasibility of developing a prophylactic vaccine against SARS was assessed by comparing the immune responses elicited by immunizing mice with a recombinant SARS spike glycoprotein (S-protein) formulated with different adjuvants, given by different routes. In both young and aged mice, an intranasal Protollin-formulated S-protein vaccine elicited high levels of antigen-specific IgG in serum, comparable to those elicited by an intramuscular Alum-adsorbed S-protein vaccine. Serum antibodies were shown to be virus neutralizing. Intranasal immunization of young mice with the Protollin-formulated vaccine elicited significant levels of antigen-specific lung IgA in contrast to mice immunized with the intramuscular vaccine in which no antigen-specific lung IgA was detected. Following live virus challenge of aged mice, no virus was detected in the lungs of intranasally immunized mice, in contrast to intramuscularly immunized mice whose lung virus titers were comparable to those observed in control mice.
journal_name
Vaccinejournal_title
Vaccineauthors
Hu MC,Jones T,Kenney RT,Barnard DL,Burt DS,Lowell GHdoi
10.1016/j.vaccine.2007.06.017subject
Has Abstractpub_date
2007-08-21 00:00:00pages
6334-40issue
34eissn
0264-410Xissn
1873-2518pii
S0264-410X(07)00695-0journal_volume
25pub_type
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