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Antibody against Haemophilus influenzae protein D in patients with chronic conditions causing secondary immunodeficiency.

Abstract：

:Prevalence of non-typeable Haemophilus influenzae (NTHi) in the etiology of invasive infections in immunocompromised individuals is increasing. Serum IgG antibody levels to H. influenzae protein D (PD) were significantly lower in adults suffering from chronic conditions causing secondary immunodeficiency (COPD, cancer, chronic renal failure, and diabetes) compared to age-matched healthy controls. A lack of naturally acquired antibody against this highly conserved antigen may contribute to an increased susceptibility to invasive NTHi disease. As COPD patients frequently infected with NTHi during disease exacerbations were unable to develop antibody response to PD, such defect could potentially contribute to the pathogenesis. Considering that pediatric PD-containing vaccines show protective effect against NTHi-caused otitis media, our data suggest the possibility of improving the defense against NTHi in COPD patients using immunization against PD. Although more research on the role of anti-PD antibody in protection against invasive NTHi disease is warranted, development of adult formulations of PD-based vaccines may be advantageous for prevention of severe infections in immunocompromised individuals.

journal_name

Vaccine

journal_title

Vaccine

authors

Hawdon N,Biman B,McCready W,Brigden M,Malik S,Vergidis D,Kisselgoff O,Ulanova M

doi

10.1016/j.vaccine.2011.12.113

subject

Has Abstract

pub_date

2012-02-08 00:00:00

pages

1235-8

issue

7

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(11)02074-3

journal_volume

30

pub_type

杂志文章

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