Evaluation of an intracellular-activated promoter for the generation of live Salmonella recombinant vaccines.

abstract：:A plasmid DNA vaccine encoding the circumsporozoite protein of malaria (pCSP) induces protective immunity in adult mice but persistent tolerance when administered to neonates. In an effort to improve antigen presenting cell (APC) function in newborns, we co-administered pCSP with a plasmid encoding granulocyte-macroph...

journal_title：Vaccine

authors： Ishii KJ,Weiss WR,Klinman DM

更新日期：1999-11-12 00:00:00

abstract：:It is well documented that adjuvants improve the immune response generated by traditional viral vaccines, but less is known about the effects of adjuvants on the immune response elicited by DNA vaccines. In this study, we have investigated the use of RN-205 (immunomodulator containing a membrane rich in lipopolysaccha...

journal_title：Vaccine

authors： Zamorano P,Taboga O,Domínguez M,Romera A,Puntel M,Tami C,Mongini C,Waldner C,Palma E,Sadir A

更新日期：2002-06-21 00:00:00

abstract：INTRODUCTION:As congenital cytomegalovirus (CMV) infection is one of the major causes of birth defects and developmental abnormalities, it is essential to develop vaccines and therapeutic antibodies against CMV. Clinical trials demonstrated that the subunit vaccine based on glycoprotein B, which had been believed to be...

journal_title：Vaccine

authors： Kobayashi R,Abe M,Oguri K,Torikai M,Nishimura T,Mori H,Koshizuka T,Inoue N

更新日期：2018-09-25 00:00:00

abstract：:Over the last ten years, Chikungunya virus (CHIKV), an Old World alphavirus has caused numerous outbreaks in Asian and European countries and the Americas, making it an emerging pathogen of great global health importance. Venezuelan equine encephalitis virus (VEEV), a New World alphavirus, on the other hand, has been ...

journal_title：Vaccine

authors： Gayen M,Gupta P,Morazzani EM,Gaidamakova EK,Knollmann-Ritschel B,Daly MJ,Glass PJ,Maheshwari RK

更新日期：2017-06-22 00:00:00

abstract：:The immunogenicity of the live oral hybrid vaccine organism Salmonella typhi Ty21a/V. cholerae Inaba (EX210) following its growth in media containing variable concentrations of supplemental galactose was examined in human volunteer subjects. The local intestinal IgA-specific antibody responses to both typhoid and chol...

journal_title：Vaccine

authors： Forrest BD,LaBrooy JT

更新日期：1991-07-01 00:00:00

abstract：:While the immunological correlates of hepatitis C virus (HCV)-specific immunity are not well understood, it is now admitted that an effective vaccine against HCV will need to induce both cellular and humoral immune responses and address viral heterogeneity to prevent immune escape. We developed a vaccine platform spec...

journal_title：Vaccine

authors： Huret C,Desjardins D,Miyalou M,Levacher B,Amadoudji Zin M,Bonduelle O,Combadière B,Dalba C,Klatzmann D,Bellier B

更新日期：2013-03-01 00:00:00

abstract：:A newly developed human diploid cell rabies vaccine (Lyssavac-HDC), produced without added serum albumin and with an effort to remove the virus-inactivating beta-propriolactone prior to addition of the gelatin, L-cysteine and potassium phosphate stabilizer, was tested for safety immunogenicity, adverse reactions and e...

journal_title：Vaccine

authors： Wilde H,Glueck R,Khawplod P,Cryz SJ,Tantawichien T,Thipkong P,Chomchey P,Prakongsri S,Benjavongkulchai M,Sumboonanondha A

更新日期：1995-04-01 00:00:00

abstract：:The co-administration of the tetravalent meningococcal conjugate vaccine, MenACWY-TT, with a licensed hepatitis A and B vaccine, HepA/B (Twinrix(®)), was compared to their separate administration in this open, randomised, controlled study. Healthy subjects 11-17 years of age (n=611) were randomised (3:1:1) to receive ...

journal_title：Vaccine

authors： Østergaard L,Silfverdal SA,Berglund J,Flodmark CE,West C,Bianco V,Baine Y,Miller JM

更新日期：2012-01-17 00:00:00

abstract：:Hepatitis E virus (HEV) is a major cause of enterically transmitted acute hepatitis of adults in developing nations. Our present studies show that, the complete ORF2 gene (1-660 amino acids, a.a.) coding for capsid protein of HEV as candidate DNA vaccine induced significant specific humoral and cellular immune respons...

journal_title：Vaccine

authors： Deshmukh TM,Lole KS,Tripathy AS,Arankalle VA

更新日期：2007-05-30 00:00:00

abstract：:Several publications have reported recently the apparently successful use of human diploid cell rabies vaccine (HDCV) in volumes of less than the 6 X 1.0 cm3 dosage schedule currently recommended by the World Health Organization for post-exposure rabies prophylaxis. The newer proposed treatments are advocated to econo...

journal_title：Vaccine

authors： Gross EM,Bearman JE

更新日期：1985-09-01 00:00:00

abstract：:Rubella is a mild disease characterized by low-grade fever, and a morbilliform rash, but causes congenital defects in neonates born from mothers who suffered from rubella during the pregnancy. After many passages of wild-type rubella virus strains in various types of cultured cells, five live attenuated rubella vaccin...

journal_title：Vaccine

authors： Otsuki N,Abo H,Kubota T,Mori Y,Umino Y,Okamoto K,Takeda M,Komase K

更新日期：2011-02-24 00:00:00

abstract：INTRODUCTION:One of the goals of the Global Measles and Rubella Strategic Plan is the reduction in global measles mortality, with high measles vaccination coverage as one of its core components. While measles mortality has been reduced more than 79%, the disease remains a major cause of childhood vaccine preventable di...

journal_title：Vaccine

authors： Doshi RH,Eckhoff P,Cheng A,Hoff NA,Mukadi P,Shidi C,Gerber S,Wemakoy EO,Muyembe-Tafum JJ,Kominski GF,Rimoin AW

更新日期：2017-10-27 00:00:00

abstract：:A fusion protein, comprising the B subunit of the heat-labile enterotoxin and a portion of the precursor to the heat-stable enterotoxin of Escherichia coli, has been created by recombinant genetic techniques. It is exported successfully to the bacterial periplasm and assembles into pentamers which retain the ability t...

journal_title：Vaccine

authors： Aitken R,Hirst TR

更新日期：1993-01-01 00:00:00

abstract：:A modern approach to vaccination faces the compound complexity of microorganism behavior and immune response triggering and regulation. Since computational modeling can yield useful guidelines for biological experimentation, we have used IMMSIM(3), a cellular automaton model for simulating humoral- and cell-mediated r...

journal_title：Vaccine

authors： Kohler B,Puzone R,Seiden PE,Celada F

更新日期：2000-11-22 00:00:00

abstract：:Vesicular stomatitis virus (VSV) has been extensively utilized as a viral vector system for the induction of protective immune responses against a variety of pathogens. We constructed recombinant VSVs specifying either the Indiana or Chandipura virus G glycoprotein and expressing the West Nile virus (WNV) envelope (E)...

journal_title：Vaccine

authors： Iyer AV,Pahar B,Boudreaux MJ,Wakamatsu N,Roy AF,Chouljenko VN,Baghian A,Apetrei C,Marx PA,Kousoulas KG

更新日期：2009-02-05 00:00:00

abstract：BACKGROUND:In the immunisation schedule in England and Wales, the 7-valent pneumococcal conjugate vaccine (PCV-7) was replaced by the 13-valent vaccine (PCV-13) in April 2010 after having been used since September 2006. The introduction of PCV-7 was informed by a cost effectiveness analysis using an infectious disease ...

journal_title：Vaccine

authors： van Hoek AJ,Choi YH,Trotter C,Miller E,Jit M

更新日期：2012-11-26 00:00:00

abstract：:Classical swine fever virus (CSFV) causes significant losses in pig industry in many countries in Asia and Europe. The E2 glycoprotein of CSFV is the main target for neutralizing antibodies. Recently, the replicon of alphaviruses, such as Semliki Forest virus (SFV), has been developed as replicative expression vectors...

journal_title：Vaccine

authors： Li N,Qiu HJ,Zhao JJ,Li Y,Wang MJ,Lu BW,Han CG,Hou Q,Wang ZH,Gao H,Peng WP,Li GX,Zhu QH,Tong GZ

更新日期：2007-04-12 00:00:00

abstract：BACKGROUND:Development of influenza vaccines that do not use embryonated eggs as the substrate for vaccine production is a high priority. We conducted this study to determine the protective efficacy a recombinant, baculovirus-expressed seasonal trivalent influenza virus hemagglutinin (rHA0) vaccine (FluBlok(®)). METHO...

journal_title：Vaccine

authors： Treanor JJ,El Sahly H,King J,Graham I,Izikson R,Kohberger R,Patriarca P,Cox M

更新日期：2011-10-13 00:00:00

abstract：:We compared the protection afforded by three different DNA application methods against bovine respiratory syncytial virus (BRSV) infection in cattle. A synthetic gene that codes for the G protein of BRSV was inserted into a eukaryotic vector and was used in the vaccine. Intradermal (i.d.) application with a needleless...

journal_title：Vaccine

authors： Schrijver RS,Langedijk JP,Keil GM,Middel WG,Maris-Veldhuis M,Van Oirschot JT,Rijsewijk FA

更新日期：1998-01-01 00:00:00

abstract：UNLABELLED:In low-income countries early measles vaccine (MV) is associated with reduced child mortality which cannot be explained by prevention of measles. A large thymus gland in infancy is also associated with reduced mortality. We hypothesized that early MV is associated with increased thymic size. Within a randomi...

journal_title：Vaccine

authors： Christensen LD,Eriksen HB,Biering-Sørensen S,Balé C,Do VA,Andersen A,Martins CL,Sodemann M,Aaby P,Benn CS

更新日期：2014-03-26 00:00:00

abstract：:Information provided by most influenza vaccine manufacturers do not reflect the recommendations of WHO and/or national public health advisory groups with regard to the use of influenza vaccines in pregnant or lactating women. The majority of vaccines contain precautionary language which could discourage use in pregnan...

journal_title：Vaccine

authors： Proveaux T,Lambach P,Ortiz JR,Hombach J,Halsey NA

更新日期：2016-10-26 00:00:00

abstract：:A placebo-controlled, double-blind study on the efficacy of a hepatitis A vaccine (SmithKline Beecham Biologicals) was started in a region of Chile in September 1990, using hepatitis B vaccine as control. A total of 260 healthy children, 6-15 years of age, negative for antibody to hepatitis A virus (anti-HAV), antibod...

journal_title：Vaccine

authors： Riedemann S,Reinhardt G,Frösner GG,Ibarra H,Moraleda L,Hering V,Siegel F,Toledo C,Leon J,Gonzalez JL

更新日期：1992-01-01 00:00:00

abstract：:In the present study, cross-protection to bovine herpesvirus type 5 (BHV-5) induced by bovine herpesvirus type 1 (BHV-1) vaccination was examined following inoculation of rabbits and calves with a glycoprotein E (gE)-negative BHV-1 vaccine and subsequent challenge with BHV-5. Rabbits (n=5) and calves (n=8) were vaccin...

journal_title：Vaccine

authors： Silva AD,Spilki FR,Franco AC,Esteves PA,Hübner SO,Driemeier D,Oliveira AP,Rijsewijk F,Roehe PM

更新日期：2006-04-12 00:00:00

abstract：:Vaccination during pregnancy is increasingly being used as an effective approach for protecting both young infants and their mothers from serious infections. Drawing conclusions from published studies in this area can be difficult because of the inability to compare vaccine trial results across different studies and s...

journal_title：Vaccine

authors： Jones CE,Munoz FM,Spiegel HM,Heininger U,Zuber PL,Edwards KM,Lambach P,Neels P,Kohl KS,Gidudu J,Hirschfeld S,Oleske JM,Khuri-Bulos N,Bauwens J,Eckert LO,Kochhar S,Bonhoeffer J,Heath PT,Brighton Collaboration Immunizat

更新日期：2016-12-01 00:00:00

abstract：:The case-centered approach (CCA) can be useful in vaccine safety studies to adjust for time varying confounders, especially seasonality. The method compares the observed odds of vaccination in the time interval prior to the event with the expected odds of vaccination during this interval. The log of the expected odds ...

journal_title：Vaccine

authors： Qian L,Tseng HF,Sy LS,Jacobsen SJ

更新日期：2013-01-02 00:00:00

abstract：BACKGROUND:Staphylococcus aureus is a pathogen which causes life-threatening infection, the incidence of which rises during adult life. This, together with the emergence of drug-resistant strains and the expansion of more susceptible elderly populations, represents the rationale for the ongoing development of S. aureus...

journal_title：Vaccine

authors： Whitehouse J,Flaxman A,Rollier C,O'Shea MK,Fallowfield J,Lindsay M,Gunner F,Knox K,Wyllie DH,Yamaguchi Y

更新日期：2016-04-04 00:00:00

abstract：:Lactobacillus spp. comprise a large group of Gram-positive lactic acid bacteria with varying physiological, ecological and immunomodulatory properties that are widely exploited by mankind, primarily in food production and as health-promoting probiotics. Recent years have shown increased interest in using lactobacilli ...

journal_title：Vaccine

authors： Kuczkowska K,Øverland L,Rocha SDC,Eijsink VGH,Mathiesen G

更新日期：2019-10-08 00:00:00

abstract：BACKGROUND:Persons with primary immunodeficiency disorders (PIDD) who receive oral poliovirus vaccine (OPV) or are household contacts of OPV recipients are at risk of excreting immunodeficiency-associated vaccine-derived polioviruses (iVDPVs). iVDPVs can be transmitted and cause paralytic polio. The objective of this s...

journal_title：Vaccine

authors： Sazzad HM,Rainey JJ,Mach O,Sutter R,Diordista S,Kawser CA,Mobarak R,Alam D,Chowdhury MA,Hossain MJ,Hasan AS,Luby SP

更新日期：2012-08-03 00:00:00

abstract：:A highly efficacious vaccine is required to counteract a threat of an avian influenza pandemic. Increasing the potency of vaccines by adjuvation is essential not only to overcome generally low immunogenicity of pandemic strains, but also to allow dose sparing and as such to make it feasible to satisfy huge global prod...

journal_title：Vaccine

authors： Radosević K,Rodriguez A,Mintardjo R,Tax D,Bengtsson KL,Thompson C,Zambon M,Weverling GJ,Uytdehaag F,Goudsmit J

更新日期：2008-07-04 00:00:00

abstract：:Development partners and donors have encouraged and incentivized governments in developing countries to explore ways of working with third-party service suppliers to reduce costs and increase service delivery capacity. The distribution of vaccines and medicines has for a long time shown demand for outsourcing but publ...

journal_title：Vaccine

authors： Wright M,Forster G,Beale J

更新日期：2017-04-19 00:00:00