Abstract:
:A plasmid DNA vaccine encoding the circumsporozoite protein of malaria (pCSP) induces protective immunity in adult mice but persistent tolerance when administered to neonates. In an effort to improve antigen presenting cell (APC) function in newborns, we co-administered pCSP with a plasmid encoding granulocyte-macrophage colony stimulating factor (pGMCSF). This combination of plasmids prevented the development of neonatal tolerance, instead eliciting a primary IgG anti-CSP immune response. Mice primed as neonates and boosted as adults mounted anamnestic responses characterized by high serum antibody titers, cytotoxic T-cell activity and antigen-specific interferon gamma (IFNgamma) production. Neonatal administration of pGMCSF accelerated the maturation of local dendritic cells, suggesting that APC function plays a key role in determining whether tolerance or immunity results from neonatal exposure to antigen.
journal_name
Vaccinejournal_title
Vaccineauthors
Ishii KJ,Weiss WR,Klinman DMdoi
10.1016/s0264-410x(99)00267-4subject
Has Abstractpub_date
1999-11-12 00:00:00pages
703-10issue
7-8eissn
0264-410Xissn
1873-2518pii
S0264410X99002674journal_volume
18pub_type
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