Prevention of neonatal tolerance by a plasmid encoding granulocyte-macrophage colony stimulating factor.

Abstract:

:A plasmid DNA vaccine encoding the circumsporozoite protein of malaria (pCSP) induces protective immunity in adult mice but persistent tolerance when administered to neonates. In an effort to improve antigen presenting cell (APC) function in newborns, we co-administered pCSP with a plasmid encoding granulocyte-macrophage colony stimulating factor (pGMCSF). This combination of plasmids prevented the development of neonatal tolerance, instead eliciting a primary IgG anti-CSP immune response. Mice primed as neonates and boosted as adults mounted anamnestic responses characterized by high serum antibody titers, cytotoxic T-cell activity and antigen-specific interferon gamma (IFNgamma) production. Neonatal administration of pGMCSF accelerated the maturation of local dendritic cells, suggesting that APC function plays a key role in determining whether tolerance or immunity results from neonatal exposure to antigen.

journal_name

Vaccine

journal_title

Vaccine

authors

Ishii KJ,Weiss WR,Klinman DM

doi

10.1016/s0264-410x(99)00267-4

subject

Has Abstract

pub_date

1999-11-12 00:00:00

pages

703-10

issue

7-8

eissn

0264-410X

issn

1873-2518

pii

S0264410X99002674

journal_volume

18

pub_type

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