Abstract：
UNLABELLED:In low-income countries early measles vaccine (MV) is associated with reduced child mortality which cannot be explained by prevention of measles. A large thymus gland in infancy is also associated with reduced mortality. We hypothesized that early MV is associated with increased thymic size. Within a randomized trial providing MV at age 4.5 and 9 months or MV only at age 9 months, thymic size was assessed by ultrasound at age 4.5 months, before randomization to early MV or no early MV, and 4 weeks later. Among 656 children, there was no effect of early MV on thymic size, the geometric mean size ratio being 0.99 (95% CI: 0.96-1.02). In a post hoc analysis early MV was associated with a negative effect in healthy children but a positive effect in ill children. In conclusion, early MV at age 4.5 months had no overall effect on thymus size 4 weeks later. TRIAL REGISTRATION:http://clinicaltrials.gov, NCT01486355.
journal_name
Vaccinejournal_title
Vaccineauthors
Christensen LD,Eriksen HB,Biering-Sørensen S,Balé C,Do VA,Andersen A,Martins CL,Sodemann M,Aaby P,Benn CSdoi
10.1016/j.vaccine.2014.01.034subject
Has Abstractpub_date
2014-03-26 00:00:00pages
1641-4issue
15eissn
0264-410Xissn
1873-2518pii
S0264-410X(14)00066-8journal_volume
32pub_type
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