Abstract:
:A modern approach to vaccination faces the compound complexity of microorganism behavior and immune response triggering and regulation. Since computational modeling can yield useful guidelines for biological experimentation, we have used IMMSIM(3), a cellular automaton model for simulating humoral- and cell-mediated responses, to explore a wide range of virus-host relations. Sixty-four virtual viruses were generated by an assortment of speed of growth, infectivity level and lethal load. The outcome of the infections, as influenced by the immune response and the bolstering of cures, obtained by vaccine presensitization are illustrated in this first article. The results of the in machina experiments allow us to relate the success rate of responses to certain combinations of viral parameters and by freezing one or the other branch, and to determine that some viruses are more susceptible to humoral, and others to cellular responses, depending either on single parameters or combinations thereof. This finding allows prediction of which infection may be susceptible to polarized ((Th)(1)>Th(2) and Th(1)
journal_name
Vaccinejournal_title
Vaccineauthors
Kohler B,Puzone R,Seiden PE,Celada Fdoi
10.1016/s0264-410x(00)00225-5subject
Has Abstractpub_date
2000-11-22 00:00:00pages
862-76issue
7-8eissn
0264-410Xissn
1873-2518pii
S0264-410X(00)00225-5journal_volume
19pub_type
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