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In vivo evidence of immunological masking of the Vibrio cholerae O antigen of a hybrid Salmonella typhi Ty21a-Vibrio cholerae oral vaccine in humans.

Abstract：

:The immunogenicity of the live oral hybrid vaccine organism Salmonella typhi Ty21a/V. cholerae Inaba (EX210) following its growth in media containing variable concentrations of supplemental galactose was examined in human volunteer subjects. The local intestinal IgA-specific antibody responses to both typhoid and cholera lipopolysaccharide (LPS) preparations were determined. It was observed that the immunogenicity of the galactose-independent Vibrio cholerae O antigen in vivo was dependent upon the variation in galactose-dependent long chain S. typhi O antigen production which was directly proportional to the media galactose concentration. It is likely that this observation was a result of steric hindrance of the presentation of the V. cholerae O antigen by S. typhi Ty21a in the presence of the longer, immunodominant S. typhi Ty21a O antigen. This observation may have relevance to the use of S. typhi vectors in vaccine development involving the presentation of LPS-associated heterologous antigens.

journal_name

Vaccine

journal_title

Vaccine

authors

Forrest BD,LaBrooy JT

doi

10.1016/0264-410x(91)90039-9

subject

Has Abstract

pub_date

1991-07-01 00:00:00

pages

515-20

issue

7

eissn

0264-410X

issn

1873-2518

pii

0264-410X(91)90039-9

journal_volume

9

pub_type

临床试验,杂志文章,随机对照试验

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